(data stored in ACNUC15260 zone)

SWISSPROT: OR1L8_HUMAN

ID   OR1L8_HUMAN             Reviewed;         309 AA.
AC   Q8NGR8; A3KFM3; B9EIR6; Q6IF15; Q96R79;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   08-MAY-2019, entry version 138.
DE   RecName: Full=Olfactory receptor 1L8;
DE   AltName: Full=Olfactory receptor OR9-24;
GN   Name=OR1L8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-211.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [7]
RP   ERRATUM.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1L8";
DR   EMBL; AB065721; BAC05942.1; -; Genomic_DNA.
DR   EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471090; EAW87536.1; -; Genomic_DNA.
DR   EMBL; BC140910; AAI40911.1; -; mRNA.
DR   EMBL; AF399564; AAK95049.1; -; Genomic_DNA.
DR   EMBL; BK004447; DAA04845.1; -; Genomic_DNA.
DR   CCDS; CCDS35124.1; -.
DR   RefSeq; NP_001004454.1; NM_001004454.1.
DR   RefSeq; XP_016869773.1; XM_017014284.1.
DR   RefSeq; XP_016869774.1; XM_017014285.1.
DR   RefSeq; XP_016869775.1; XM_017014286.1.
DR   STRING; 9606.ENSP00000306607; -.
DR   iPTMnet; Q8NGR8; -.
DR   PhosphoSitePlus; Q8NGR8; -.
DR   BioMuta; OR1L8; -.
DR   DMDM; 38372757; -.
DR   jPOST; Q8NGR8; -.
DR   PaxDb; Q8NGR8; -.
DR   PeptideAtlas; Q8NGR8; -.
DR   PRIDE; Q8NGR8; -.
DR   ProteomicsDB; 73585; -.
DR   Ensembl; ENST00000304865; ENSP00000306607; ENSG00000171496.
DR   Ensembl; ENST00000641027; ENSP00000493411; ENSG00000171496.
DR   GeneID; 138881; -.
DR   KEGG; hsa:138881; -.
DR   UCSC; uc004bmp.1; human.
DR   CTD; 138881; -.
DR   GeneCards; OR1L8; -.
DR   HGNC; HGNC:15110; OR1L8.
DR   neXtProt; NX_Q8NGR8; -.
DR   PharmGKB; PA32088; -.
DR   eggNOG; ENOG410IFXJ; Eukaryota.
DR   eggNOG; ENOG41114P7; LUCA.
DR   GeneTree; ENSGT00940000165018; -.
DR   HOGENOM; HOG000041364; -.
DR   InParanoid; Q8NGR8; -.
DR   KO; K04257; -.
DR   OMA; ERINHTS; -.
DR   PhylomeDB; Q8NGR8; -.
DR   TreeFam; TF341149; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GeneWiki; OR1L8; -.
DR   GenomeRNAi; 138881; -.
DR   PRO; PR:Q8NGR8; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000171496; Expressed in 56 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; Q8NGR8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8NGR8.
DR   SWISS-2DPAGE; Q8NGR8.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    309       Olfactory receptor 1L8.
FT                                /FTId=PRO_0000150446.
FT   TOPO_DOM      1     26       Extracellular. {ECO:0000255}.
FT   TRANSMEM     27     50       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     51     58       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     59     80       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     81    101       Extracellular. {ECO:0000255}.
FT   TRANSMEM    102    121       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    122    140       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    141    159       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    160    197       Extracellular. {ECO:0000255}.
FT   TRANSMEM    198    220       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    221    237       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    238    260       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    261    272       Extracellular. {ECO:0000255}.
FT   TRANSMEM    273    292       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    293    309       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      5      5       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     98    190       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT      27     27       T -> P (in dbSNP:rs10985704).
FT                                /FTId=VAR_024087.
FT   VARIANT     211    211       R -> P (in dbSNP:rs10739614).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_024088.
SQ   SEQUENCE   309 AA;  35083 MW;  CA8113D975B09361 CRC64;
     MERINHTSSV SEFILLGLSS RPEDQKTLFV LFLIVYLVTI TGNLLIILAI RFNPHLQTPM
     YFFLSFLSLT DICFTTSVVP KMLMNFLSEK KTISYAGCLT QMYFLYALGN SDSCLLAVMA
     FDRYVAVCDP FHYVTTMSHH HCVLLVAFSC SFPHLHSLLH TLLLNRLTFC DSNVIHHFLC
     DLSPVLKLSC SSIFVNEIVQ MTEAPIVLVT RFLCIAFSYI RILTTVLKIP STSGKRKAFS
     TCGFYLTVVT LFYGSIFCVY LQPPSTYAVK DHVATIVYTV LSSMLNPFIY SLRNKDLKQG
     LRKLMSKRS
//

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