(data stored in ACNUC7820 zone)

SWISSPROT: OR8S1_HUMAN

ID   OR8S1_HUMAN             Reviewed;         359 AA.
AC   Q8NH09;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   30-AUG-2017, entry version 113.
DE   RecName: Full=Olfactory receptor 8S1;
GN   Name=OR8S1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-48.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8S1";
DR   EMBL; AB065604; BAC05832.1; -; Genomic_DNA.
DR   EMBL; AC089987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS31789.1; -.
DR   RefSeq; NP_001005203.2; NM_001005203.2.
DR   UniGene; Hs.524373; -.
DR   ProteinModelPortal; Q8NH09; -.
DR   STRING; 9606.ENSP00000310632; -.
DR   iPTMnet; Q8NH09; -.
DR   PhosphoSitePlus; Q8NH09; -.
DR   BioMuta; OR8S1; -.
DR   DMDM; 296439256; -.
DR   EPD; Q8NH09; -.
DR   PaxDb; Q8NH09; -.
DR   PRIDE; Q8NH09; -.
DR   Ensembl; ENST00000310194; ENSP00000310632; ENSG00000197376.
DR   GeneID; 341568; -.
DR   KEGG; hsa:341568; -.
DR   UCSC; uc010slu.2; human.
DR   CTD; 341568; -.
DR   DisGeNET; 341568; -.
DR   GeneCards; OR8S1; -.
DR   HGNC; HGNC:19628; OR8S1.
DR   HPA; HPA045595; -.
DR   neXtProt; NX_Q8NH09; -.
DR   PharmGKB; PA134896911; -.
DR   eggNOG; ENOG410IVNF; Eukaryota.
DR   eggNOG; ENOG41116B6; LUCA.
DR   GeneTree; ENSGT00440000034852; -.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   InParanoid; Q8NH09; -.
DR   KO; K04257; -.
DR   OMA; SVQYTVV; -.
DR   OrthoDB; EOG091G0E8E; -.
DR   PhylomeDB; Q8NH09; -.
DR   TreeFam; TF338386; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GenomeRNAi; 341568; -.
DR   PRO; PR:Q8NH09; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000197376; -.
DR   CleanEx; HS_OR8S1; -.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8NH09.
DR   SWISS-2DPAGE; Q8NH09.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    359       Olfactory receptor 8S1.
FT                                /FTId=PRO_0000150674.
FT   TOPO_DOM      1     25       Extracellular. {ECO:0000255}.
FT   TRANSMEM     26     46       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     47     54       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     55     75       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     76     99       Extracellular. {ECO:0000255}.
FT   TRANSMEM    100    120       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    121    139       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    140    160       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    161    197       Extracellular. {ECO:0000255}.
FT   TRANSMEM    198    217       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    218    237       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    238    258       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    259    269       Extracellular. {ECO:0000255}.
FT   TRANSMEM    270    290       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    291    359       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      5      5       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     97    189       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT      48     48       M -> V (in dbSNP:rs2731073).
FT                                {ECO:0000269|Ref.1}.
FT                                /FTId=VAR_034275.
FT   VARIANT      82     82       L -> P (in dbSNP:rs4075258).
FT                                /FTId=VAR_057566.
FT   VARIANT     128    128       R -> C (in dbSNP:rs12425460).
FT                                /FTId=VAR_057567.
FT   CONFLICT    127    127       C -> R (in Ref. 1; BAC05832).
FT                                {ECO:0000305}.
FT   CONFLICT    198    198       A -> V (in Ref. 1; BAC05832).
FT                                {ECO:0000305}.
SQ   SEQUENCE   359 AA;  39645 MW;  C8A0D6B7E2977643 CRC64;
     MALGNHSTIT EFLLLGLSAD PNIRALLFVL FLGIYLLTIM ENLMLLLMIR ADSCLHKPMY
     FFLSHLSFVD LCFSSVIVPK MLENLLSQRK TISVEGCLAQ VFFVFVTAGT EACLLSGMAY
     DRHAAICRPL LYGQIMGKQL YMHLVWGSWG LGFLDALINV LLAVNMVFCE AKIIHHYSYE
     MPSLLPLSCS DISRSLIALL CSTLLHGLGN FLLVFLSYTR IISTILSISS TSGRSKAFST
     CSAHLTAVTL YYGSGLLRHL MPNSGSPIEL IFSVQYTVVT PMLNSLIYSL KNKEVKGERS
     LRDSSHLPQL HKGQARWKRP AFTEGRREPG HPELSIPVTP QPQGACACSA LRAAPTALP
//

If you have problems or comments...

PBIL Back to PBIL home page