(data stored in SCRATCH zone)

SWISSPROT: PXPA_FUSNN

ID   PXPA_FUSNN              Reviewed;         257 AA.
AC   Q8RG75;
DT   04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   11-DEC-2019, entry version 75.
DE   RecName: Full=5-oxoprolinase subunit A {ECO:0000255|HAMAP-Rule:MF_00691};
DE            Short=5-OPase subunit A {ECO:0000255|HAMAP-Rule:MF_00691};
DE            EC=3.5.2.9 {ECO:0000255|HAMAP-Rule:MF_00691};
DE   AltName: Full=5-oxoprolinase (ATP-hydrolyzing) subunit A {ECO:0000255|HAMAP-Rule:MF_00691};
GN   Name=pxpA {ECO:0000255|HAMAP-Rule:MF_00691}; OrderedLocusNames=FN0439;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 /
OS   JCM 8532 / LMG 13131).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- FUNCTION: Catalyzes the cleavage of 5-oxoproline to form L-glutamate
CC       coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
CC       {ECO:0000255|HAMAP-Rule:MF_00691}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate +
CC         phosphate; Xref=Rhea:RHEA:10348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58402, ChEBI:CHEBI:456216; EC=3.5.2.9;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00691};
CC   -!- SUBUNIT: Forms a complex composed of PxpA, PxpB and PxpC.
CC       {ECO:0000255|HAMAP-Rule:MF_00691}.
CC   -!- SIMILARITY: Belongs to the LamB/PxpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00691}.
DR   EMBL; AE009951; AAL94638.1; -; Genomic_DNA.
DR   RefSeq; NP_603339.1; NC_003454.1.
DR   RefSeq; WP_011016390.1; NC_003454.1.
DR   SMR; Q8RG75; -.
DR   STRING; 190304.FN0439; -.
DR   EnsemblBacteria; AAL94638; AAL94638; FN0439.
DR   GeneID; 992789; -.
DR   KEGG; fnu:FN0439; -.
DR   PATRIC; fig|190304.8.peg.1012; -.
DR   eggNOG; ENOG4105E7W; Bacteria.
DR   eggNOG; COG1540; LUCA.
DR   HOGENOM; HOG000237330; -.
DR   InParanoid; Q8RG75; -.
DR   KO; K07160; -.
DR   OMA; VNIACGF; -.
DR   BioCyc; FNUC190304:G1FZS-1033-MONOMER; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   HAMAP; MF_00691; PxpA; 1.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR005501; LamB/YcsF/PxpA-like.
DR   PANTHER; PTHR30292; PTHR30292; 1.
DR   Pfam; PF03746; LamB_YcsF; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8RG75.
DR   SWISS-2DPAGE; Q8RG75.
KW   ATP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..257
FT                   /note="5-oxoprolinase subunit A"
FT                   /id="PRO_0000185011"
SQ   SEQUENCE   257 AA;  28314 MW;  912ECD274E1512B5 CRC64;
     MKFFVDLNSD IGEGYGAYKL GMDEEIMKCV TSVNCACGWH AGDPLIMDKT IKIAKENNVA
     VGAHPGYPDL LGFGRRKMVV TPDEARAYML YQLGALNAFA KANETKLQHM KLHGAFYNMA
     AVEKDLADAV LDGIEQFDKD IIVMTLSGSY MAKEGKRRGL KVAEEVFADR GYNPDGTLVN
     RNLPGAFVKE PDEAIARVIK MIKTKKVTAV NGEEIDIAAD SICVHGDNPK AIEFVDRIRK
     SLIADGIEVK SLYEFIK
//

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