(data stored in ACNUC21562 zone)

SWISSPROT: MRGRD_HUMAN

ID   MRGRD_HUMAN             Reviewed;         321 AA.
AC   Q8TDS7; Q8NGK7;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   08-MAY-2019, entry version 129.
DE   RecName: Full=Mas-related G-protein coupled receptor member D;
DE   AltName: Full=Beta-alanine receptor;
DE   AltName: Full=G-protein coupled receptor TGR7;
GN   Name=MRGPRD; Synonyms=MRGD;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G
RT   protein-coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND POSSIBLE
RP   FUNCTION.
RC   TISSUE=Liver;
RX   PubMed=15037633; DOI=10.1074/jbc.M314240200;
RA   Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
RA   Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T.,
RA   Moriya T., Itoh Y., Hinuma S.;
RT   "Identification of a G protein-coupled receptor specifically
RT   responsive to beta-alanine.";
RL   J. Biol. Chem. 279:23559-23564(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12044878; DOI=10.1016/S0014-5793(02)02775-8;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human
RT   genome sequence.";
RL   FEBS Lett. 520:97-101(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate nociceptor function and/or development,
CC       including the sensation or modulation of pain. Functions as a
CC       specific membrane receptor for beta-alanine. Beta-alanine at
CC       micromolar doses specifically evoked Ca(2+) influx in cells
CC       expressing the receptor. Beta-alanine decreases forskolin-
CC       stimulated cAMP production in cells expressing the receptor,
CC       suggesting that the receptor couples with G-protein G(q) and G(i).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15037633};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:15037633}.
CC       Note=Localized at the plasma membrane but internalized into the
CC       cytoplasm after treatment with beta-alanine.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC06005.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AY427820; AAR05120.1; -; mRNA.
DR   EMBL; AB154410; BAD20638.1; -; mRNA.
DR   EMBL; AB083627; BAB89340.1; -; Genomic_DNA.
DR   EMBL; AB065786; BAC06005.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS31625.1; -.
DR   RefSeq; NP_944605.2; NM_198923.2.
DR   STRING; 9606.ENSP00000310631; -.
DR   GuidetoPHARMACOLOGY; 152; -.
DR   iPTMnet; Q8TDS7; -.
DR   PhosphoSitePlus; Q8TDS7; -.
DR   BioMuta; MRGPRD; -.
DR   DMDM; 50401085; -.
DR   PaxDb; Q8TDS7; -.
DR   PRIDE; Q8TDS7; -.
DR   ProteomicsDB; 74337; -.
DR   DNASU; 116512; -.
DR   Ensembl; ENST00000309106; ENSP00000310631; ENSG00000172938.
DR   GeneID; 116512; -.
DR   KEGG; hsa:116512; -.
DR   UCSC; uc010rqf.2; human.
DR   CTD; 116512; -.
DR   DisGeNET; 116512; -.
DR   GeneCards; MRGPRD; -.
DR   HGNC; HGNC:29626; MRGPRD.
DR   HPA; HPA031346; -.
DR   MIM; 607231; gene.
DR   neXtProt; NX_Q8TDS7; -.
DR   OpenTargets; ENSG00000172938; -.
DR   PharmGKB; PA134978563; -.
DR   eggNOG; ENOG410IWY7; Eukaryota.
DR   eggNOG; ENOG41117F1; LUCA.
DR   GeneTree; ENSGT00950000182854; -.
DR   HOGENOM; HOG000015412; -.
DR   InParanoid; Q8TDS7; -.
DR   KO; K08392; -.
DR   OMA; YWFVLYW; -.
DR   OrthoDB; 737211at2759; -.
DR   PhylomeDB; Q8TDS7; -.
DR   TreeFam; TF336336; -.
DR   GeneWiki; MRGPRD; -.
DR   GenomeRNAi; 116512; -.
DR   PRO; PR:Q8TDS7; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000172938; Expressed in 34 organ(s), highest expression level in lower esophagus muscularis layer.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd15108; 7tmA_MrgprD; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026232; MRGPCRD.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02110; MRGPCRD.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8TDS7.
DR   SWISS-2DPAGE; Q8TDS7.
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    321       Mas-related G-protein coupled receptor
FT                                member D.
FT                                /FTId=PRO_0000069756.
FT   TOPO_DOM      1     33       Extracellular. {ECO:0000255}.
FT   TRANSMEM     34     54       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     55     59       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     60     80       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     81    112       Extracellular. {ECO:0000255}.
FT   TRANSMEM    113    133       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    134    142       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    143    163       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    164    184       Extracellular. {ECO:0000255}.
FT   TRANSMEM    185    205       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    206    218       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    219    239       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    240    257       Extracellular. {ECO:0000255}.
FT   TRANSMEM    258    280       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    281    321       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      2      2       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD      6      6       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     16     16       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     92     92       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   321 AA;  36118 MW;  B45AB7FEB2154B40 CRC64;
     MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW LLGFRMHRNP
     FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL MKRLMYFAYT VGLSLLTAIS
     TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM
     VQAALIMGVL TPVMTLSSLT LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY
     WFVLYWLSLP PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL
     REEPELEGGE TPTVGTNEMG A
//

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