(data stored in SCRATCH zone)

SWISSPROT: Q8XBS1_ECO57

ID   Q8XBS1_ECO57            Unreviewed;       381 AA.
AC   Q8XBS1; Q7AGP9;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   07-JUN-2017, entry version 105.
DE   RecName: Full=[Citrate [pro-3S]-lyase] ligase {ECO:0000256|PIRNR:PIRNR005751};
DE            EC=6.2.1.22 {ECO:0000256|PIRNR:PIRNR005751};
GN   Name=citC {ECO:0000313|EMBL:AAG54953.1};
GN   OrderedLocusNames=ECs0657 {ECO:0000313|EMBL:BAB34080.1}, Z0762
GN   {ECO:0000313|EMBL:AAG54953.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:BAB34080.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC   {ECO:0000313|Proteomes:UP000000558}, and Sakai
RC   {ECO:0000313|EMBL:BAB34080.1};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2] {ECO:0000313|EMBL:AAG54953.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EDL933 {ECO:0000313|EMBL:AAG54953.1}, and O157:H7 / EDL933 /
RC   ATCC 700927 / EHEC {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- FUNCTION: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-
CC       3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
CC       {ECO:0000256|PIRNR:PIRNR005751}.
CC   -!- CATALYTIC ACTIVITY: ATP + acetate + [citrate (pro-3S)-lyase](thiol
CC       form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form).
CC       {ECO:0000256|PIRNR:PIRNR005751}.
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DR   EMBL; AE005174; AAG54953.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34080.1; -; Genomic_DNA.
DR   PIR; A90711; A90711.
DR   PIR; E85561; E85561.
DR   RefSeq; NP_308684.2; NC_002695.1.
DR   STRING; 155864.Z0762; -.
DR   EnsemblBacteria; AAG54953; AAG54953; Z0762.
DR   EnsemblBacteria; BAB34080; BAB34080; BAB34080.
DR   GeneID; 917017; -.
DR   KEGG; ece:Z0762; -.
DR   KEGG; ecs:ECs0657; -.
DR   PATRIC; fig|386585.9.peg.768; -.
DR   eggNOG; ENOG4105DUA; Bacteria.
DR   eggNOG; COG3053; LUCA.
DR   HOGENOM; HOG000117934; -.
DR   KO; K01910; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0008771; F:[citrate (pro-3S)-lyase] ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR005216; Citrate_lyase_ligase.
DR   InterPro; IPR013166; Citrate_lyase_ligase_C.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF08218; Citrate_ly_lig; 1.
DR   PIRSF; PIRSF005751; Acet_citr_lig; 1.
DR   SMART; SM00764; Citrate_ly_lig; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR00124; cit_ly_ligase; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   4: Predicted;
DR   PRODOM; Q8XBS1.
DR   SWISS-2DPAGE; Q8XBS1.
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR005751};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558,
KW   ECO:0000313|Proteomes:UP000002519};
KW   Ligase {ECO:0000256|PIRNR:PIRNR005751, ECO:0000313|EMBL:AAG54953.1};
KW   Lyase {ECO:0000313|EMBL:AAG54953.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR005751}.
FT   DOMAIN       19    157       N-acetyltransferase.
FT                                {ECO:0000259|PROSITE:PS51186}.
SQ   SEQUENCE   381 AA;  43420 MW;  8BB5DF1B8C309863 CRC64;
     MKIKGYQFAT LNNIRCKSIT TCTFRILFIM FGNDIFTRVK RSENKKMAEI AQFLHENDLS
     VDTTVEVFIT VTRDEKLIAC GGIAGNIIKC VAISESVRGE GLALTLATEL INLAYERHST
     HLFIYTKTEY EALFRQCGFS TLTSVPGVMV LMENSATRLK RYAESLKKFR HPGNKIGCIA
     MNANPFTNGH RYLIQQAAAQ CDWLHLFLVK EDSSRFPYED RLDLVLKGTA DIPRLTVHRG
     SEYIISRATF PCYFIKEQSV INHCYTEIDL KIFRQYLAPA LGVTHRFVGT ESFCRVTAQY
     NQDMRYWLET PTISAAPIEL VEIERLRYQE MPISASRVRQ LLAKNDLTAI APLVPAVTLH
     YLQNLLEHSR QDAAARQKTP A
//

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