(data stored in SCRATCH zone)

SWISSPROT: Q8XD35_ECO57

ID   Q8XD35_ECO57            Unreviewed;       550 AA.
AC   Q8XD35; Q7AGY0;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 124.
DE   SubName: Full=UDP-sugar hydrolase {ECO:0000313|EMBL:BAB33956.1};
DE   SubName: Full=UDP-sugar hydrolase (5'-nucleotidase) {ECO:0000313|EMBL:AAG54829.1};
GN   Name=ushA {ECO:0000313|EMBL:AAG54829.1};
GN   OrderedLocusNames=ECs0533 {ECO:0000313|EMBL:BAB33956.1}, Z0599
GN   {ECO:0000313|EMBL:AAG54829.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:BAB33956.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC   {ECO:0000313|Proteomes:UP000000558}, and Sakai
RC   {ECO:0000313|EMBL:BAB33956.1};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2] {ECO:0000313|EMBL:AAG54829.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EDL933 {ECO:0000313|EMBL:AAG54829.1}, and O157:H7 / EDL933 /
RC   ATCC 700927 / EHEC {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|RuleBase:RU362119}.
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DR   EMBL; AE005174; AAG54829.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33956.1; -; Genomic_DNA.
DR   PIR; A85546; A85546.
DR   PIR; E90695; E90695.
DR   RefSeq; NP_308560.1; NC_002695.1.
DR   RefSeq; WP_000771719.1; NZ_MWVM01000009.1.
DR   STRING; 155864.Z0599; -.
DR   EnsemblBacteria; AAG54829; AAG54829; Z0599.
DR   EnsemblBacteria; BAB33956; BAB33956; BAB33956.
DR   GeneID; 914637; -.
DR   KEGG; ece:Z0599; -.
DR   KEGG; ecs:ECs0533; -.
DR   PATRIC; fig|386585.9.peg.640; -.
DR   eggNOG; ENOG4105CGH; Bacteria.
DR   eggNOG; COG0737; LUCA.
DR   HOGENOM; HOG000247216; -.
DR   KO; K11751; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.780.10; -; 1.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR006146; 5'-Nucleotdase_CS.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR11575; PTHR11575; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF55816; SSF55816; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
DR   PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XD35.
DR   SWISS-2DPAGE; Q8XD35.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558,
KW   ECO:0000313|Proteomes:UP000002519};
KW   Hydrolase {ECO:0000256|RuleBase:RU362119,
KW   ECO:0000313|EMBL:AAG54829.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362119};
KW   Signal {ECO:0000256|RuleBase:RU362119}.
FT   SIGNAL        1     25       {ECO:0000256|RuleBase:RU362119}.
FT   CHAIN        26    550       {ECO:0000256|RuleBase:RU362119}.
FT                                /FTId=PRO_5010396861.
FT   DOMAIN       35    254       Metallophos. {ECO:0000259|Pfam:PF00149}.
FT   DOMAIN      363    509       5_nucleotid_C. {ECO:0000259|Pfam:
FT                                PF02872}.
SQ   SEQUENCE   550 AA;  60731 MW;  20D83A796F55C48E CRC64;
     MKLLQRGVAL ALLTTFTLAS EAALAYEQDK TYKITVLHTN DHHGHFWRNE YGEYGLAAQK
     TLVDGIRKEV AAEGGSVLLL SGGDINTGVP ESDLQDAEPD FRGMNLVGYD AMAIGNHEFD
     NPLTVLRQQE KWAKFPLLSA NIYQKSTGER LFKPWALFKR QDLKIAVIGL TTDDTAKLGN
     PENFTDIEFR KPADEAKLVI QELQQTEKPD IIIAATHMGH YDNGDHGSNA PGDVEMARAL
     PAGSLAMIVG GHSQDPVCMA AENKKQVDYV PGTPCKPDQQ NGIWIVQAHE WGKYVGRADF
     EFRNGEMKMV NYQLIPVNLK KKVTWEDGKS ERVLYTPEIA ENQQMISLLS PFQNKGKAQL
     EVKIGETNGR LEGDRDKVRF VQTNMGRLIL AAQMDRTGAD FAVMSGGGIR DSIEAGDISY
     KNVLKVQPFG NVVVYADMTG KEVIDYLTAV AQMKPDSGAY PQFANVSFVA KDGKLNDLKI
     KGEPVDPAKT YRMATLNFNA TGGDGYPRLD NKPGYVNTGF IDAEVLKAYI QKSSPLDVSV
     YEPKGEVSWQ
//

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