(data stored in SCRATCH zone)

SWISSPROT: Q8XE86_ECO57

ID   Q8XE86_ECO57            Unreviewed;       171 AA.
AC   Q8XE86; Q7AH11;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 108.
DE   RecName: Full=Phosphatidylglycerophosphatase A {ECO:0000256|PIRNR:PIRNR006162};
DE            EC=3.1.3.27 {ECO:0000256|PIRNR:PIRNR006162};
DE   AltName: Full=Phosphatidylglycerolphosphate phosphatase A {ECO:0000256|PIRNR:PIRNR006162};
GN   Name=pgpA {ECO:0000313|EMBL:AAG54767.1};
GN   OrderedLocusNames=ECs0471 {ECO:0000313|EMBL:BAB33894.1}, Z0520
GN   {ECO:0000313|EMBL:AAG54767.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:BAB33894.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC   {ECO:0000313|Proteomes:UP000000558}, and Sakai
RC   {ECO:0000313|EMBL:BAB33894.1};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2] {ECO:0000313|EMBL:AAG54767.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EDL933 {ECO:0000313|EMBL:AAG54767.1}, and O157:H7 / EDL933 /
RC   ATCC 700927 / EHEC {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- FUNCTION: Lipid phosphatase which dephosphorylates
CC       phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
CC       {ECO:0000256|PIRNR:PIRNR006162}.
CC   -!- CATALYTIC ACTIVITY: Phosphatidylglycerophosphate + H(2)O =
CC       phosphatidylglycerol + phosphate. {ECO:0000256|PIRNR:PIRNR006162}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006162};
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylglycerol
CC       biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step
CC       2/2. {ECO:0000256|PIRNR:PIRNR006162}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|PIRNR:PIRNR006162}; Multi-pass membrane protein
CC       {ECO:0000256|PIRNR:PIRNR006162}.
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DR   EMBL; AE005174; AAG54767.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33894.1; -; Genomic_DNA.
DR   PIR; C85538; C85538.
DR   PIR; G90687; G90687.
DR   RefSeq; NP_308498.1; NC_002695.1.
DR   RefSeq; WP_000154043.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; Q8XE86; -.
DR   STRING; 155864.Z0520; -.
DR   EnsemblBacteria; AAG54767; AAG54767; Z0520.
DR   EnsemblBacteria; BAB33894; BAB33894; BAB33894.
DR   GeneID; 914573; -.
DR   KEGG; ece:Z0520; -.
DR   KEGG; ecs:ECs0471; -.
DR   PATRIC; fig|386585.9.peg.571; -.
DR   eggNOG; ENOG4108ZAI; Bacteria.
DR   eggNOG; COG1267; LUCA.
DR   HOGENOM; HOG000256112; -.
DR   KO; K01095; -.
DR   UniPathway; UPA00084; UER00504.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008962; F:phosphatidylglycerophosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006655; P:phosphatidylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009395; P:phospholipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd06971; PgpA; 1.
DR   Gene3D; 1.10.3760.10; -; 1.
DR   InterPro; IPR026037; PgpA.
DR   InterPro; IPR007686; YutG/PgpA.
DR   Pfam; PF04608; PgpA; 1.
DR   PIRSF; PIRSF006162; PgpA; 1.
DR   SUPFAM; SSF101307; SSF101307; 1.
PE   4: Predicted;
DR   PRODOM; Q8XE86.
DR   SWISS-2DPAGE; Q8XE86.
KW   Cell inner membrane {ECO:0000256|PIRNR:PIRNR006162};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR006162};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558,
KW   ECO:0000313|Proteomes:UP000002519};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006162};
KW   Lipid degradation {ECO:0000256|PIRNR:PIRNR006162};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR006162};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR006162};
KW   Membrane {ECO:0000256|PIRNR:PIRNR006162, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR006162};
KW   Phospholipid degradation {ECO:0000256|PIRNR:PIRNR006162};
KW   Phospholipid metabolism {ECO:0000256|PIRNR:PIRNR006162};
KW   Transmembrane {ECO:0000256|PIRNR:PIRNR006162,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     21     51       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     57     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    162       PgpA. {ECO:0000259|Pfam:PF04608}.
SQ   SEQUENCE   171 AA;  19331 MW;  B1C817CA36C8B9A4 CRC64;
     MTILPRHKDV AKSRLKMSNP WHLLAVGFGS GLSPIVPGTM GSLAAIPFWY LMTFLPWQLY
     SLVVMLGICI GVYLCHQTAK DMGVHDHGSI VWDEFIGMWI TLMALPTNDW QWVAAGFVIF
     RILDMWKPWP IRWFDRNVHG GMGIMIDDIV AGVISAGILY FIGHHWPLGI L
//

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