(data stored in SCRATCH zone)

SWISSPROT: Q8XEJ6_ECO57

ID   Q8XEJ6_ECO57            Unreviewed;      1047 AA.
AC   Q8XEJ6;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 105.
DE   RecName: Full=Nuclease SbcCD subunit C {ECO:0000256|RuleBase:RU363070};
GN   Name=sbcC {ECO:0000256|RuleBase:RU363070,
GN   ECO:0000313|EMBL:AAG54743.1};
GN   OrderedLocusNames=Z0495 {ECO:0000313|EMBL:AAG54743.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:AAG54743.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC
RC   {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures
CC       can inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double
CC       strand exonuclease that can open hairpins. It also has a 5'
CC       single-strand endonuclease activity.
CC       {ECO:0000256|RuleBase:RU363070}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD.
CC       {ECO:0000256|RuleBase:RU363070}.
CC   -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily.
CC       {ECO:0000256|RuleBase:RU363070}.
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DR   EMBL; AE005174; AAG54743.1; -; Genomic_DNA.
DR   PIR; C85535; C85535.
DR   PIR; G90684; G90684.
DR   RefSeq; WP_000698892.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; Q8XEJ6; -.
DR   EnsemblBacteria; AAG54743; AAG54743; Z0495.
DR   KEGG; ece:Z0495; -.
DR   PATRIC; fig|83334.175.peg.5387; -.
DR   eggNOG; ENOG4105EYH; Bacteria.
DR   eggNOG; COG0419; LUCA.
DR   HOGENOM; HOG000280831; -.
DR   KO; K03546; -.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004592; SbcC_gammaproteobac_type.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00618; sbcc; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XEJ6.
DR   SWISS-2DPAGE; Q8XEJ6.
KW   Coiled coil {ECO:0000256|RuleBase:RU363070};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002519};
KW   DNA recombination {ECO:0000256|RuleBase:RU363070};
KW   DNA replication {ECO:0000256|RuleBase:RU363070};
KW   Endonuclease {ECO:0000256|RuleBase:RU363070};
KW   Exonuclease {ECO:0000256|RuleBase:RU363070,
KW   ECO:0000313|EMBL:AAG54743.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU363070};
KW   Nuclease {ECO:0000256|RuleBase:RU363070}.
FT   COILED      238    276       {ECO:0000256|RuleBase:RU363070}.
FT   COILED      532    580       {ECO:0000256|RuleBase:RU363070}.
FT   COILED      618    645       {ECO:0000256|RuleBase:RU363070}.
FT   COILED      772    806       {ECO:0000256|RuleBase:RU363070}.
SQ   SEQUENCE   1047 AA;  118509 MW;  EC570030E1384B85 CRC64;
     MKILSLRLKN LNSLKGEWKI DFTREPFASN GLFAITGPTG AGKTTLLDAI CLALYHETPR
     LSNVSQSQND LMTRDTAECL AEVEFEVKGE AYRAFWSQNR ARNQPDGNLQ VPRVELARCA
     DGKILADKVK DKLELTATLT GLDYGRFTRS MLLSQGQFAA FLNAKPKERA ELLEELTGTE
     IYGQISAMVF EQHKSARTEL EKLQAQASGV ALLTPEQVQS LTASLQVLTD EEKQLLTAQQ
     QEQQSLNWLT RLDELQQEAS RRQQALQQAL AEEEKAQPQL AALSLAQPAR NLRPHWERIA
     EHSAALAHTR QQIEEVNTRL QNTMALRASI RHHAAKQSAE LQQQQQSLNT WLQEHDRFRQ
     WNNELAGWRA QFSQQTSDRE HLRQWQQQLT HAEQKLNALA AITLMLTADE VATALAQHAE
     QRPLRQRLVA LHGQIVPQQK RLAQLMVTIQ NVTLEQTQRN AALNEMRQRY KEKTQQLADV
     KTICEQEARI KTLEAQRAQL QAGQPCPLCG STSHPAVEAY QALEPGVNQS RLLALENEVK
     KLGEEGAALR GQLDALTKQL QRDENEAQSL RQDEQALTQQ WQAVTASLNI TLQPQDDIQP
     WLDAQDEHER QLRLLSQRHE LQGQIAAHNQ QIIQYQQQIE QRQQQLLTAL AGYALTLPQE
     DEEESWLATR QQEAQSWQQR QNELTALQNR IQQLTPILET LPQSDDLPHS EETVALDNWR
     QVHEQCLALH SQQQTLQQQD VLAAQSLQKA QAQFDTALQA SVFDDQQAFL AALMDEQTLT
     QLEQLKQNLE NQRRQAQTLV TQTAETLAQH QQHRPDGLAL TVTVEQIQQE LAQTHQKLRE
     NTTSQGEIRQ QLKQDADNRQ QQQTLLQQIA QMTQQVEDWG YLNSLIGSKE GDKFRKFAQG
     LTLDNLVHLA NQQLTRLHGR YLLQRKASEA LEVEVVDTWQ ADAVRDTRTL SGGESFLVSL
     ALALALSDLV SHKTRIDSLF LDEGFGTLDS ETLDTALDAL DALNASGKTI GVISHVEAMK
     ERIPVQIKVK KINGLGYSKL ESTFAVK
//

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