(data stored in ACNUC7421 zone)

SWISSPROT: CAID_SALTY

ID   CAID_SALTY              Reviewed;         261 AA.
AC   Q8ZRX5;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   07-JUN-2017, entry version 88.
DE   RecName: Full=Carnitinyl-CoA dehydratase;
DE            EC=4.2.1.149;
DE   AltName: Full=Crotonobetainyl-CoA hydratase;
GN   Name=caiD; OrderedLocusNames=STM0070;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the reversible dehydration of L-carnitinyl-CoA
CC       to crotonobetainyl-CoA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: L-carnitinyl-CoA = (E)-4-
CC       (trimethylammonio)but-2-enoyl-CoA + H(2)O.
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
DR   EMBL; AE006468; AAL19034.1; -; Genomic_DNA.
DR   RefSeq; NP_459075.1; NC_003197.2.
DR   RefSeq; WP_000004385.1; NC_003197.2.
DR   ProteinModelPortal; Q8ZRX5; -.
DR   SMR; Q8ZRX5; -.
DR   STRING; 99287.STM0070; -.
DR   PaxDb; Q8ZRX5; -.
DR   PRIDE; Q8ZRX5; -.
DR   EnsemblBacteria; AAL19034; AAL19034; STM0070.
DR   GeneID; 1251588; -.
DR   KEGG; stm:STM0070; -.
DR   PATRIC; fig|99287.12.peg.72; -.
DR   eggNOG; ENOG4106YT9; Bacteria.
DR   eggNOG; COG1024; LUCA.
DR   HOGENOM; HOG000027939; -.
DR   KO; K08299; -.
DR   OMA; KGRAMEM; -.
DR   PhylomeDB; Q8ZRX5; -.
DR   UniPathway; UPA00117; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IBA:GO_Central.
DR   GO; GO:0009437; P:carnitine metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   Gene3D; 1.10.12.10; -; 1.
DR   HAMAP; MF_01051; CaiD; 1.
DR   InterPro; IPR022852; Carnitinyl_CoA_dehydratase.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom.
DR   InterPro; IPR014748; Crontonase_C.
DR   InterPro; IPR001753; Crotonase_core_superfam.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8ZRX5.
DR   SWISS-2DPAGE; Q8ZRX5.
KW   Complete proteome; Lyase; Reference proteome.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    261       Carnitinyl-CoA dehydratase.
FT                                /FTId=PRO_0000109353.
FT   SITE        111    111       Important for catalytic activity.
FT                                {ECO:0000250}.
FT   SITE        131    131       Important for catalytic activity.
FT                                {ECO:0000250}.
SQ   SEQUENCE   261 AA;  28106 MW;  11413296E72B4BAF CRC64;
     MSESLHLTRN GPILEITLDR PKANAIDAKT SFAMGEAFLN FRDDPELRVA IITGGGEKFF
     SAGWDLKAAA EGEAPDADFG PGGFAGLTEI FDLDKPVIAA VNGYAFGGGF ELALAADFIV
     CAENASFALP EAKLGIVPDS GGVLRLPKLL PPAIVNEMVM TGRRMSAEEA LRWGVVNRVV
     SQSELMESAR ELAQQLVNSA PLAIAALKEI YRATSEMPVE EGYRYIRSGV LKHYPSVLHS
     EDALEGPQAF AEKRDPVWKG R
//

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