(data stored in ACNUC21562 zone)

SWISSPROT: MRGA4_MOUSE

ID   MRGA4_MOUSE             Reviewed;         313 AA.
AC   Q91WW2; Q1RLL1;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 2.
DT   08-MAY-2019, entry version 118.
DE   RecName: Full=Mas-related G-protein coupled receptor member A4;
DE   AltName: Full=RF-amide G-protein coupled receptor;
GN   Name=Mrgpra4; Synonyms=Mrga4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX   PubMed=11551509; DOI=10.1016/S0092-8674(01)00483-4;
RA   Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT   "A diverse family of GPCRs expressed in specific subsets of
RT   nociceptive sensory neurons.";
RL   Cell 106:619-632(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
CC       neuropeptides such as NPFF and NPAF, which are analgesic in vivo.
CC       May regulate nociceptor function and/or development, including the
CC       sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11551509};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:11551509}.
CC   -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
CC       includes nociceptors. Expressed in the subclass of non-peptidergic
CC       sensory neurons that are IB4(+) and VR1(-).
CC       {ECO:0000269|PubMed:11551509}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
DR   EMBL; AY042194; AAK91790.1; -; mRNA.
DR   EMBL; AC144923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466603; EDL22963.1; -; Genomic_DNA.
DR   EMBL; BC115741; AAI15742.1; -; mRNA.
DR   CCDS; CCDS21298.1; -.
DR   RefSeq; NP_705744.2; NM_153524.2.
DR   STRING; 10090.ENSMUSP00000084327; -.
DR   PaxDb; Q91WW2; -.
DR   PRIDE; Q91WW2; -.
DR   Ensembl; ENSMUST00000087092; ENSMUSP00000084327; ENSMUSG00000067173.
DR   GeneID; 235854; -.
DR   KEGG; mmu:235854; -.
DR   UCSC; uc009hak.1; mouse.
DR   CTD; 235854; -.
DR   MGI; MGI:3033100; Mrgpra4.
DR   eggNOG; ENOG410J9NM; Eukaryota.
DR   eggNOG; ENOG4111AUB; LUCA.
DR   GeneTree; ENSGT00950000182854; -.
DR   HOGENOM; HOG000015412; -.
DR   InParanoid; Q91WW2; -.
DR   KO; K08396; -.
DR   OMA; YCALLLM; -.
DR   OrthoDB; 1123658at2759; -.
DR   TreeFam; TF336336; -.
DR   PRO; PR:Q91WW2; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000067173; Expressed in 8 organ(s), highest expression level in spleen.
DR   ExpressionAtlas; Q91WW2; baseline and differential.
DR   Genevisible; Q91WW2; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0008188; F:neuropeptide receptor activity; IDA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd15105; 7tmA_MrgprA; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026233; MRGPCRA.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02109; MRGPCRA.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q91WW2.
DR   SWISS-2DPAGE; Q91WW2.
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    313       Mas-related G-protein coupled receptor
FT                                member A4.
FT                                /FTId=PRO_0000069750.
FT   TOPO_DOM      1     25       Extracellular. {ECO:0000255}.
FT   TRANSMEM     26     46       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     47     54       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     55     75       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     76     93       Extracellular. {ECO:0000255}.
FT   TRANSMEM     94    114       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    115    137       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    138    158       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    159    182       Extracellular. {ECO:0000255}.
FT   TRANSMEM    183    203       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    204    219       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    220    240       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    241    255       Extracellular. {ECO:0000255}.
FT   TRANSMEM    256    276       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    277    313       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     10     10       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     76     76       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT    204    204       A -> G (in Ref. 1; AAK91790).
FT                                {ECO:0000305}.
SQ   SEQUENCE   313 AA;  35682 MW;  A428C370BBD0F202 CRC64;
     MAPTTTNPMN ETIPGSIDIE TLIPNLMIII FGLVGLTGNV ILFWLLGFHL HRNAFLVYIL
     NLALADFLFL LCHIINSTML LLKVHLPNNI LNHCFDIIMT VLYITGLSML SAISTERCLS
     VLCPIWYRCR RPEHTSTVLC AVIWFLPLLI CILNGYFCHF FGPKYVIDSV CLATNFFIRT
     YPMFLFIVLC LSTLALLARL FCGAGKTKFT RLFVTIMLTV LVFLLCGLPL GFFWFLVPWI
     NRDFSVLDYI LFQTSLVLTS VNSCANPIIY FFVGSFRHRL KHKTLKMVLQ SALQDTPETP
     ENMVEMSRSK AEP
//

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