(data stored in ACNUC15260 zone)

SWISSPROT: O14A2_HUMAN

ID   O14A2_HUMAN             Reviewed;         314 AA.
AC   Q96R54;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   08-MAY-2019, entry version 119.
DE   RecName: Full=Olfactory receptor 14A2;
DE   AltName: Full=Olfactory receptor 5AX1;
DE   AltName: Full=Olfactory receptor OR1-31;
GN   Name=OR14A2; Synonyms=OR5AX1, OR5AX1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14A2";
DR   EMBL; AB065620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399589; AAK95074.1; -; Genomic_DNA.
DR   EMBL; BK004620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86063.1; -.
DR   STRING; 9606.ENSP00000355441; -.
DR   BioMuta; OR14A2; -.
DR   DMDM; 206558302; -.
DR   PaxDb; Q96R54; -.
DR   PRIDE; Q96R54; -.
DR   ProteomicsDB; 77931; -.
DR   Ensembl; ENST00000366485; ENSP00000355441; ENSG00000241128.
DR   UCSC; uc057rau.1; human.
DR   GeneCards; OR14A2; -.
DR   HGNC; HGNC:15024; OR14A2.
DR   HPA; HPA052685; -.
DR   neXtProt; NX_Q96R54; -.
DR   eggNOG; ENOG410IEM2; Eukaryota.
DR   eggNOG; ENOG410YBQN; LUCA.
DR   GeneTree; ENSGT00950000182791; -.
DR   HOGENOM; HOG000041364; -.
DR   InParanoid; Q96R54; -.
DR   OMA; AYFVYLK; -.
DR   PhylomeDB; Q96R54; -.
DR   TreeFam; TF352740; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   PRO; PR:Q96R54; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000241128; Expressed in 3 organ(s), highest expression level in left testis.
DR   ExpressionAtlas; Q96R54; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q96R54.
DR   SWISS-2DPAGE; Q96R54.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    314       Olfactory receptor 14A2.
FT                                /FTId=PRO_0000344440.
FT   TOPO_DOM      1     26       Extracellular. {ECO:0000255}.
FT   TRANSMEM     27     47       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     48     55       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     56     76       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     77     91       Extracellular. {ECO:0000255}.
FT   TRANSMEM     92    112       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    113    136       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    137    157       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    158    193       Extracellular. {ECO:0000255}.
FT   TRANSMEM    194    214       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    215    237       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    238    258       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    259    267       Extracellular. {ECO:0000255}.
FT   TRANSMEM    268    290       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    291    314       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      3      3       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     83     83       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     95    177       {ECO:0000255|PROSITE-ProRule:PRU00521}.
SQ   SEQUENCE   314 AA;  34780 MW;  8EE5299FF6898842 CRC64;
     MANVTLVTGF LLMGFSNIQK LRILYGVLFL LIYLAALMSN LLIITLITLD VKLQTPMYFF
     LKNLSFLDVF LVSVPIPKFI VNNLTHNNSI SILGCAFQLL LMTSFSAGEI FILTAMSYDR
     YVAICCPLNY EVIMNTGVCV LMASVSWAIG GLFGTAYTAG TFSMPFCGSS VIPQFFCDVP
     SLLRISCSET LMVIYAGIGV GACLSISCFI CIVISYIYIF STVLKIPTTK GQSKAFSTCF
     PHLTVFTVFI ITAYFVYLKP PSNSPSVIDR LLSVIYTVMP PVFNPVTYSL RNNDMKCALI
     RLLQKTYGQE AYFI
//

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