(data stored in ACNUC21562 zone)

SWISSPROT: MRGRH_MOUSE

ID   MRGRH_MOUSE             Reviewed;         321 AA.
AC   Q99MT8; Q149S2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   08-MAY-2019, entry version 111.
DE   RecName: Full=Mas-related G-protein coupled receptor member H;
DE   AltName: Full=G-protein coupled receptor 90;
GN   Name=Mrgprh; Synonyms=Gpr90, Mrgh;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11273702; DOI=10.1006/jmbi.2001.4520;
RA   Wittenberger T., Schaller H.C., Hellebrand S.;
RT   "An expressed sequence tag (EST) data mining strategy succeeding in
RT   the discovery of new G-protein coupled receptors.";
RL   J. Mol. Biol. 307:799-813(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
DR   EMBL; AF295365; AAK01865.1; -; mRNA.
DR   EMBL; BC116696; AAI16697.1; -; mRNA.
DR   EMBL; BC117525; AAI17526.1; -; mRNA.
DR   CCDS; CCDS28395.1; -.
DR   RefSeq; NP_109651.1; NM_030726.1.
DR   STRING; 10090.ENSMUSP00000074768; -.
DR   PaxDb; Q99MT8; -.
DR   PRIDE; Q99MT8; -.
DR   Ensembl; ENSMUST00000075296; ENSMUSP00000074768; ENSMUSG00000059408.
DR   GeneID; 80978; -.
DR   KEGG; mmu:80978; -.
DR   UCSC; uc008alg.1; mouse.
DR   CTD; 80978; -.
DR   MGI; MGI:1934134; Mrgprh.
DR   eggNOG; ENOG410IFZP; Eukaryota.
DR   eggNOG; ENOG410YK5N; LUCA.
DR   GeneTree; ENSGT00950000182854; -.
DR   HOGENOM; HOG000015412; -.
DR   InParanoid; Q99MT8; -.
DR   KO; K22793; -.
DR   OMA; GLENFFC; -.
DR   OrthoDB; 1136752at2759; -.
DR   PhylomeDB; Q99MT8; -.
DR   TreeFam; TF336336; -.
DR   PRO; PR:Q99MT8; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000059408; Expressed in 13 organ(s), highest expression level in heart.
DR   ExpressionAtlas; Q99MT8; baseline and differential.
DR   Genevisible; Q99MT8; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   InterPro; IPR026221; MRGPCRH.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   PANTHER; PTHR11334:SF60; PTHR11334:SF60; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PRINTS; PR02113; MRGPCRH.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q99MT8.
DR   SWISS-2DPAGE; Q99MT8.
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    321       Mas-related G-protein coupled receptor
FT                                member H.
FT                                /FTId=PRO_0000069770.
FT   TOPO_DOM      1     35       Extracellular. {ECO:0000255}.
FT   TRANSMEM     36     56       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     57     71       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     72     92       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     93    102       Extracellular. {ECO:0000255}.
FT   TRANSMEM    103    126       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    127    147       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    148    168       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    169    188       Extracellular. {ECO:0000255}.
FT   TRANSMEM    189    209       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    210    225       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    226    246       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    247    247       Extracellular. {ECO:0000255}.
FT   TRANSMEM    248    271       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    272    320       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     23     23       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     99     99       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   321 AA;  36911 MW;  03712FB7205F475E CRC64;
     MEPLAMTLYP LESTQPTRNK TPNETTWSSE HTDDHTYFLV SLVICSLGLA GNGLLIWFLI
     FCIKRKPFTI YILHLAIADF MVLLCSSIMK LVNTFHIYNM TLESYAILFM IFGYNTGLHL
     LTAISVERCL SVLYPIWYQC QRPKHQSAVA CMLLWALSVL VSGLENFFCI LEVKPQFPEC
     RYVYIFSCIL TFLVFVPLMI FSNLILFIQV CCNLKPRQPT KLYVIIMTTV ILFLVFAMPM
     KVLLIIGYYS SSLDDSVWDS LPYLNMLSTI NCSINPIVYF VVGSLRRKRS RKSLKEALQK
     VFEEKPVVAS RENVTQFSLP S
//

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