(data stored in SCRATCH zone)

SWISSPROT: ORML2_MOUSE

ID   ORML2_MOUSE             Reviewed;         153 AA.
AC   Q9CQZ0; Q8CF72; Q9CSJ7; Q9CVL6;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   07-JUN-2017, entry version 113.
DE   RecName: Full=ORM1-like protein 2;
GN   Name=Ormdl2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Kidney, and Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Negative regulator of sphingolipid synthesis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9CQZ0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9CQZ0-2; Sequence=VSP_016051;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the ORM family. {ECO:0000305}.
DR   EMBL; AK002583; BAB22207.1; -; mRNA.
DR   EMBL; AK002824; BAC25010.1; -; mRNA.
DR   EMBL; AK007548; BAB25101.1; -; mRNA.
DR   EMBL; AK012681; BAB28407.1; -; mRNA.
DR   EMBL; AK013455; BAB28864.1; -; mRNA.
DR   EMBL; BC002146; AAH02146.1; -; mRNA.
DR   CCDS; CCDS24295.1; -. [Q9CQZ0-1]
DR   RefSeq; NP_077142.1; NM_024180.5. [Q9CQZ0-1]
DR   RefSeq; XP_006514022.1; XM_006513959.2. [Q9CQZ0-1]
DR   UniGene; Mm.235562; -.
DR   UniGene; Mm.296915; -.
DR   IntAct; Q9CQZ0; 7.
DR   STRING; 10090.ENSMUSP00000026409; -.
DR   iPTMnet; Q9CQZ0; -.
DR   PhosphoSitePlus; Q9CQZ0; -.
DR   PaxDb; Q9CQZ0; -.
DR   PeptideAtlas; Q9CQZ0; -.
DR   PRIDE; Q9CQZ0; -.
DR   TopDownProteomics; Q9CQZ0-1; -. [Q9CQZ0-1]
DR   Ensembl; ENSMUST00000026409; ENSMUSP00000026409; ENSMUSG00000025353. [Q9CQZ0-1]
DR   Ensembl; ENSMUST00000217685; ENSMUSP00000151644; ENSMUSG00000025353. [Q9CQZ0-2]
DR   Ensembl; ENSMUST00000219215; ENSMUSP00000151335; ENSMUSG00000025353. [Q9CQZ0-1]
DR   Ensembl; ENSMUST00000219524; ENSMUSP00000151697; ENSMUSG00000025353. [Q9CQZ0-1]
DR   GeneID; 66844; -.
DR   KEGG; mmu:66844; -.
DR   UCSC; uc007hoo.2; mouse. [Q9CQZ0-1]
DR   CTD; 29095; -.
DR   MGI; MGI:1914094; Ormdl2.
DR   eggNOG; KOG3319; Eukaryota.
DR   eggNOG; COG5081; LUCA.
DR   GeneTree; ENSGT00390000015817; -.
DR   HOGENOM; HOG000192741; -.
DR   HOVERGEN; HBG080033; -.
DR   InParanoid; Q9CQZ0; -.
DR   OMA; VPLVWTL; -.
DR   OrthoDB; EOG091G0S5I; -.
DR   PhylomeDB; Q9CQZ0; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-MMU-1660661; Sphingolipid de novo biosynthesis.
DR   PRO; PR:Q9CQZ0; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   Bgee; ENSMUSG00000025353; -.
DR   CleanEx; MM_ORMDL2; -.
DR   Genevisible; Q9CQZ0; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IBA:GO_Central.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; ISO:MGI.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029886; ORML2.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF21; PTHR12665:SF21; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q9CQZ0.
DR   SWISS-2DPAGE; Q9CQZ0.
KW   Alternative splicing; Complete proteome; Endoplasmic reticulum;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    153       ORM1-like protein 2.
FT                                /FTId=PRO_0000215637.
FT   TRANSMEM     22     42       Helical. {ECO:0000255}.
FT   TRANSMEM     43     63       Helical. {ECO:0000255}.
FT   VAR_SEQ       1     59       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_016051.
FT   CONFLICT     37     37       L -> P (in Ref. 1; BAB28407).
FT                                {ECO:0000305}.
SQ   SEQUENCE   153 AA;  17390 MW;  3ECCA8B2DB88ED66 CRC64;
     MNVGVAHSEV NPNTRVMNSR GIWLAYIILV GLLHVVLLSI PFFSIPVVWT LTNVIHNLAM
     YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGLQFTSSRK FLSISPIVLY LLASFYTKYD
     AAHFLINTAS LLSVLLPKLP QFHGVRLFGI NKY
//

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