(data stored in SCRATCH zone)

SWISSPROT: Q9FCJ8_STRCO

ID   Q9FCJ8_STRCO            Unreviewed;       122 AA.
AC   Q9FCJ8; Q8GHG1;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   16-JAN-2019, entry version 90.
DE   RecName: Full=Transcriptional regulator WhiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   Name=whiB7 {ECO:0000313|EMBL:AAO15313.1};
GN   Synonyms=whiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   OrderedLocusNames=SCO5190 {ECO:0000313|EMBL:CAC01320.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAC01320.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A3 {ECO:0000313|EMBL:CAC01320.1}, and ATCC BAA-471 / A3(2) /
RC   M145 {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
RN   [2] {ECO:0000313|EMBL:AAO15313.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M145 {ECO:0000313|EMBL:AAO15313.1};
RX   PubMed=16103351; DOI=10.1073/pnas.0505446102;
RA   Morris R.P., Nguyen L., Gatfield J., Visconti K., Nguyen K.,
RA   Schnappinger D., Ehrt S., Liu Y., Heifets L., Pieters J.,
RA   Schoolnik G., Thompson C.J.;
RT   "Ancestral antibiotic resistance in Mycobacterium tuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12200-12205(2005).
CC   -!- FUNCTION: Acts as a transcriptional regulator. Probably redox-
CC       responsive. The apo- but not holo-form probably binds DNA.
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01479};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation
CC       of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_01479};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: Upon Fe-S cluster removal intramolecular disulfide bonds are
CC       formed. {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- SIMILARITY: Belongs to the WhiB family. {ECO:0000256|HAMAP-
CC       Rule:MF_01479}.
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DR   EMBL; AF205848; AAO15313.1; -; Genomic_DNA.
DR   EMBL; AL939122; CAC01320.1; -; Genomic_DNA.
DR   RefSeq; NP_629338.1; NC_003888.3.
DR   RefSeq; WP_003973786.1; NC_003888.3.
DR   STRING; 100226.SCO5190; -.
DR   EnsemblBacteria; CAC01320; CAC01320; CAC01320.
DR   GeneID; 1100631; -.
DR   KEGG; sco:SCO5190; -.
DR   PATRIC; fig|100226.15.peg.5273; -.
DR   eggNOG; ENOG4105WBQ; Bacteria.
DR   eggNOG; ENOG4112352; LUCA.
DR   HOGENOM; HOG000247631; -.
DR   KO; K18958; -.
DR   OMA; RTCPLVE; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0035731; F:dinitrosyl-iron complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015035; F:protein disulfide oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0047134; F:protein-disulfide reductase activity; IBA:GO_Central.
DR   GO; GO:0045454; P:cell redox homeostasis; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   HAMAP; MF_01479; WhiB; 1.
DR   InterPro; IPR034768; 4FE4S_WBL.
DR   InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR   InterPro; IPR003482; Whib.
DR   PANTHER; PTHR38839; PTHR38839; 1.
DR   Pfam; PF02467; Whib; 1.
DR   PROSITE; PS51674; 4FE4S_WBL; 1.
DR   PROSITE; PS00354; HMGI_Y; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9FCJ8.
DR   SWISS-2DPAGE; Q9FCJ8.
KW   4Fe-4S {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001973};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_01479};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01479,
KW   ECO:0000313|EMBL:CAC01320.1}; Iron {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   DOMAIN       48    105       4Fe-4S Wbl-type. {ECO:0000259|PROSITE:
FT                                PS51674}.
FT   METAL        49     49       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        49     49       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        72     72       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        72     72       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        75     75       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        75     75       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        81     81       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        81     81       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
SQ   SEQUENCE   122 AA;  13201 MW;  41063B4F0DA45CB3 CRC64;
     MQLEAHAPSV PPSDTIPKPC STEDSTLTPL TALTALDDAI ENLGVPVPCR SYDPEVFFAE
     SPADVEYAKS LCRTCPLIEA CLAGAKERRE PWGVWGGELF VQGVVVARKR PRGRPRKNPV
     SA
//

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