(data stored in SCRATCH zone)

SWISSPROT: Q9FCK0_STRCO

ID   Q9FCK0_STRCO            Unreviewed;       785 AA.
AC   Q9FCK0;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   08-MAY-2019, entry version 110.
DE   RecName: Full=DNA helicase {ECO:0000256|SAAS:SAAS00413339};
DE            EC=3.6.4.12 {ECO:0000256|SAAS:SAAS00413339};
GN   OrderedLocusNames=SCO5188 {ECO:0000313|EMBL:CAC01318.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAC01318.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
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DR   EMBL; AL939122; CAC01318.1; -; Genomic_DNA.
DR   RefSeq; NP_629336.1; NC_003888.3.
DR   RefSeq; WP_011030106.1; NC_003888.3.
DR   STRING; 100226.SCO5188; -.
DR   EnsemblBacteria; CAC01318; CAC01318; CAC01318.
DR   GeneID; 1100629; -.
DR   KEGG; sco:SCO5188; -.
DR   PATRIC; fig|100226.15.peg.5272; -.
DR   eggNOG; ENOG4105C4R; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   HOGENOM; HOG000033018; -.
DR   InParanoid; Q9FCK0; -.
DR   KO; K03657; -.
DR   OMA; LLLYWAQ; -.
DR   PhylomeDB; Q9FCK0; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033202; C:DNA helicase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000725; P:recombinational repair; IBA:GO_Central.
DR   Gene3D; 1.10.10.160; -; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; SSF47819; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50967; HRDC; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
DR   PRODOM; Q9FCK0.
DR   SWISS-2DPAGE; Q9FCK0.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001973};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:CAC01318.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT   DOMAIN       72    352       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      353    608       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
FT   DOMAIN      703    783       HRDC. {ECO:0000259|PROSITE:PS50967}.
SQ   SEQUENCE   785 AA;  84523 MW;  0CE60606C5E61D0B CRC64;
     MRSHGVNVRG GTTIPVAHSH RVMPVALIRL SVRACGQPTH PSRETWQHGG VTAATHSTLF
     PQVPDSADAV LEGLDLEQRE VATALRGPVC VLAGAGTGKT RAITHRIAYG VRAGILQPSS
     VLAVTFTNRA AGEMRGRLRQ LGASGVQART FHSAALRQLQ YFWPKAIGGS LPRLVDRKIQ
     LVADAAAACR IRLDRGELRD VTAEIEWSKV TQTVPADYAP AAAKAGREAP RDPAEIAQLY
     AAYEDLKRAR SVIDFEDVLL LTVAVLQDRH DVAEQVRAQY QHFVVDEYQD VSPLQQRLLE
     LWLGDRDDLC VVGDASQTIY SFTGATPDHL LDFRGRHPGA TVVKLVRDYR STPQVVHLAN
     GLLAQARGRA ADHRLELVSQ RPAGPEPGYA EYSDEPAEAE GAARRIRELI DSGVPAAEIA
     VLFRTNSQSE TYEQALADAG VPYQLRGAER FFDRPEVRKA GSALRAAARF GGNDSLLDDA
     VDLPSQVRAV LSGEGWTTQP PAGSGAVRER WESLAALVGL AQDFAAARAG ATLSDLVVEL
     DERAGAQHAP TVQGVTLASL HSAKGLEWDV VFLVGVAEGM MPITYAKTDE QIEEERRLLY
     VGVTRARERL HLSWALARSP GGRPNRRPSR FLKGLRPGSG TAGGQAAAAG AGGVERGIRG
     GGGGGAAAAP RRTQRTPARC RVCGRTLTDA GEMKLMRCEG CPSDMDEGVY ERLREWRAVQ
     AGRSGQPAFC VFTDKTLMAI AESVPEDERE LARIPGVGMR KLNRYGTDVL AICAGQEGVG
     LDEDD
//

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