(data stored in ACNUC15324 zone)

SWISSPROT: IL24_RAT

ID   IL24_RAT                Reviewed;         183 AA.
AC   Q9JI24;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   08-MAY-2019, entry version 110.
DE   RecName: Full=Interleukin-24;
DE            Short=IL-24;
DE   AltName: Full=Cytokine-like protein Mob-5;
DE   Flags: Precursor;
GN   Name=Il24; Synonyms=Mob5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10825166; DOI=10.1074/jbc.M001958200;
RA   Zhang R., Tan Z., Liang P.;
RT   "Identification of a novel ligand-receptor pair constitutively
RT   activated by ras oncogenes.";
RL   J. Biol. Chem. 275:24436-24443(2000).
CC   -!- FUNCTION: Has antiproliferative properties on melanoma cells and
CC       may contribute to terminal cell differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Ubiquitination at Lys-99 promotes proteasomal degradation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
DR   EMBL; AF269251; AAF75553.1; -; mRNA.
DR   RefSeq; NP_579845.1; NM_133311.1.
DR   SMR; Q9JI24; -.
DR   STRING; 10116.ENSRNOP00000006106; -.
DR   PaxDb; Q9JI24; -.
DR   PRIDE; Q9JI24; -.
DR   Ensembl; ENSRNOT00000006106; ENSRNOP00000006106; ENSRNOG00000004470.
DR   GeneID; 170819; -.
DR   KEGG; rno:170819; -.
DR   UCSC; RGD:621484; rat.
DR   CTD; 11009; -.
DR   RGD; 621484; Il24.
DR   eggNOG; ENOG410IZYS; Eukaryota.
DR   eggNOG; ENOG41119SI; LUCA.
DR   GeneTree; ENSGT00950000183124; -.
DR   HOGENOM; HOG000113033; -.
DR   InParanoid; Q9JI24; -.
DR   KO; K22668; -.
DR   OMA; ESCYLVH; -.
DR   OrthoDB; 1434107at2759; -.
DR   PhylomeDB; Q9JI24; -.
DR   TreeFam; TF333253; -.
DR   PRO; PR:Q9JI24; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000004470; Expressed in 8 organ(s), highest expression level in spleen.
DR   Genevisible; Q9JI24; RN.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0071353; P:cellular response to interleukin-4; IEP:RGD.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0030336; P:negative regulation of cell migration; IDA:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:RGD.
DR   GO; GO:0042501; P:serine phosphorylation of STAT protein; IDA:RGD.
DR   GO; GO:0042060; P:wound healing; IEP:RGD.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020423; IL-10_CS.
DR   InterPro; IPR020444; IL-24.
DR   PRINTS; PR01937; INTRLEUKIN24.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9JI24.
DR   SWISS-2DPAGE; Q9JI24.
KW   Apoptosis; Complete proteome; Cytokine; Glycoprotein; Isopeptide bond;
KW   Reference proteome; Secreted; Signal; Ubl conjugation.
FT   SIGNAL        1     28       {ECO:0000255}.
FT   CHAIN        29    183       Interleukin-24.
FT                                /FTId=PRO_0000015388.
FT   CARBOHYD     76     76       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CROSSLNK     99     99       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250|UniProtKB:Q13007}.
SQ   SEQUENCE   183 AA;  21096 MW;  AF7A11466C491AC4 CRC64;
     MQTSLRQQIL PGLSLILLVL NQVPELQGQE FRFGPCQVTG VVLPELWEAF WTVKNTVKTQ
     DELTSVRLLK PQVLQNVSDA ESCYLAHSLL KFYLNTVFKN YHSKIVKFKV LKSFSTLANN
     FLVIMSKLQP SKDNAMLPIS DSARRRFLLY HRTFKQLDIE VALAKAFGEV DILLAWMQNF
     YQL
//

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