(data stored in ACNUC22857 zone)

SWISSPROT: Q9N4F3_CAEEL

ID   Q9N4F3_CAEEL            Unreviewed;       955 AA.
AC   Q9N4F3;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 2.
DT   30-AUG-2017, entry version 125.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   Name=apb-1 {ECO:0000313|EMBL:CCD72406.1,
GN   ECO:0000313|WormBase:Y71H2B.10a};
GN   ORFNames=CELE_Y71H2B.10 {ECO:0000313|EMBL:CCD72406.1}, Y71H2B.10
GN   {ECO:0000313|WormBase:Y71H2B.10a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72406.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD72406.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72406.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00556307}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; BX284603; CCD72406.1; -; Genomic_DNA.
DR   RefSeq; NP_001022937.1; NM_001027766.3.
DR   UniGene; Cel.22457; -.
DR   ProteinModelPortal; Q9N4F3; -.
DR   SMR; Q9N4F3; -.
DR   DIP; DIP-27411N; -.
DR   IntAct; Q9N4F3; 2.
DR   MINT; MINT-116366; -.
DR   STRING; 6239.Y71H2B.10a.1; -.
DR   EPD; Q9N4F3; -.
DR   PaxDb; Q9N4F3; -.
DR   PeptideAtlas; Q9N4F3; -.
DR   EnsemblMetazoa; Y71H2B.10a; Y71H2B.10a; WBGene00000160.
DR   GeneID; 175376; -.
DR   UCSC; Y71H2B.10a; c. elegans.
DR   CTD; 175376; -.
DR   WormBase; Y71H2B.10a; CE29919; WBGene00000160; apb-1.
DR   eggNOG; KOG1061; Eukaryota.
DR   eggNOG; COG5096; LUCA.
DR   GeneTree; ENSGT00530000063138; -.
DR   HOGENOM; HOG000163270; -.
DR   InParanoid; Q9N4F3; -.
DR   OMA; ARASMVW; -.
DR   OrthoDB; EOG091G019U; -.
DR   PhylomeDB; Q9N4F3; -.
DR   Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000160; -.
DR   ExpressionAtlas; Q9N4F3; baseline.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.60.40.1150; -; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR013041; Coatomer/clathrin_app_Ig-like.
DR   PANTHER; PTHR11134; PTHR11134; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 2.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q9N4F3.
DR   SWISS-2DPAGE; Q9N4F3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00101884};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00468902};
KW   Proteomics identification {ECO:0000213|EPD:Q9N4F3,
KW   ECO:0000213|PeptideAtlas:Q9N4F3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00299740}.
FT   DOMAIN      729    835       Alpha_adaptinC2. {ECO:0000259|SMART:
FT                                SM00809}.
FT   DOMAIN      844    955       B2-adapt-app_C. {ECO:0000259|SMART:
FT                                SM01020}.
SQ   SEQUENCE   955 AA;  105253 MW;  14E9E5B6D587B7A6 CRC64;
     MTDSKYFTTT KKGEIFELKN ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT
     DNVELKKLVY LYLMNYAKSQ PDLAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVEKITE
     YLCDPLRRCM KDEDPYVRKT AAVCVAKLHD MNPALVKEQG FVELLNDLLS DANPMVVANA
     VAALTEMNEQ QTVIEVNSQM VNKLLTALNE CTEWGQVFIL DALAGYTPRD ERETQNICER
     ISPRLAHANA AVVLSTVKVL MKLIDMMPAD SDFITQLTKK LAPPMVTLLS AEPEIQYVAL
     RNINLIVQKR PDILKQEMKV FFVKYNDPIY VKMEKLDIMI RLAQQNNIAQ VLSELKEYAT
     EVDVDFVRKS VRAIGRCAIK VEASSERCVQ TLLELIQTKV NYVVQEAVVV IKDIFRKYPN
     RYESIISALC ENLDTLDEPE ARASMIWIIG EYAERIDNAD ELLESFVEGF HDENTQVQLQ
     LLTAVVKLFL KRPGVAQALV QRVLSLATQD SDNPDLRDRG FIYWRLLSAD PAAAKNVVLT
     EKPLISEETD LLEPSLLEQL VCHIGTLASV YHKPPSAFID PAKAPLRQIN PIPAAKFGSS
     LLDTSSTPNA ARNGSAAAPT VIPSQDQVIA DLLSLDLNAP AASANTGAFG GAMSGTTSMG
     GLDDLLGLGG DPMPAAPTNS ASYNPFDGLG GLGGAAPAAP PSQQPASIGG LAEIFGSGGF
     GGSSGITYPK ELWLDASKAM GMQVEGTFVR RGGKIFMEMT ITNRAMQAIS GFALQFNKNS
     FGLIPVEQVN PAPILPNQSQ NYTIACDTTG AVQVTTPLTN LQVAIKNDIN AFYFATTVPL
     LAYFREDGQM EKREFLEEWK SIPEQNEQQF TLQNTHNMNA DAICTKLQQN NIHTVARRQV
     DNQQLLYHSV KYTNNLNVLS ELKVNSQTTS ITLSLKSKNL MAIANINEVF QALLN
//

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