(data stored in SCRATCH zone)

SWISSPROT: CCNJ_HUMAN

ID   CCNJ_HUMAN              Reviewed;         372 AA.
AC   Q5T5M9; B7Z4E7; Q86XL1; Q9NV69;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   12-APR-2017, entry version 104.
DE   RecName: Full=Cyclin-J;
GN   Name=CCNJ;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 127-372 (ISOFORM 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q5T5M9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5T5M9-2; Sequence=VSP_029128;
CC       Name=3;
CC         IsoId=Q5T5M9-3; Sequence=VSP_041163;
CC   -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91887.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AK001757; BAA91887.1; ALT_INIT; mRNA.
DR   EMBL; AK297264; BAH12533.1; -; mRNA.
DR   EMBL; AL356155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC043175; AAH43175.1; -; mRNA.
DR   CCDS; CCDS44462.1; -. [Q5T5M9-3]
DR   CCDS; CCDS44463.1; -. [Q5T5M9-2]
DR   CCDS; CCDS7445.1; -. [Q5T5M9-1]
DR   RefSeq; NP_001127847.1; NM_001134375.1. [Q5T5M9-3]
DR   RefSeq; NP_001127848.1; NM_001134376.1. [Q5T5M9-2]
DR   RefSeq; NP_061957.2; NM_019084.4. [Q5T5M9-1]
DR   RefSeq; XP_011538187.1; XM_011539885.2. [Q5T5M9-3]
DR   UniGene; Hs.596479; -.
DR   ProteinModelPortal; Q5T5M9; -.
DR   BioGrid; 120077; 5.
DR   IntAct; Q5T5M9; 1.
DR   STRING; 9606.ENSP00000388902; -.
DR   iPTMnet; Q5T5M9; -.
DR   PhosphoSitePlus; Q5T5M9; -.
DR   BioMuta; CCNJ; -.
DR   DMDM; 160380581; -.
DR   EPD; Q5T5M9; -.
DR   PaxDb; Q5T5M9; -.
DR   PeptideAtlas; Q5T5M9; -.
DR   PRIDE; Q5T5M9; -.
DR   DNASU; 54619; -.
DR   Ensembl; ENST00000265992; ENSP00000265992; ENSG00000107443. [Q5T5M9-1]
DR   Ensembl; ENST00000403870; ENSP00000384498; ENSG00000107443. [Q5T5M9-2]
DR   Ensembl; ENST00000465148; ENSP00000435373; ENSG00000107443. [Q5T5M9-3]
DR   GeneID; 54619; -.
DR   KEGG; hsa:54619; -.
DR   UCSC; uc001klm.4; human. [Q5T5M9-1]
DR   CTD; 54619; -.
DR   DisGeNET; 54619; -.
DR   GeneCards; CCNJ; -.
DR   HGNC; HGNC:23434; CCNJ.
DR   HPA; HPA036531; -.
DR   HPA; HPA058151; -.
DR   neXtProt; NX_Q5T5M9; -.
DR   OpenTargets; ENSG00000107443; -.
DR   PharmGKB; PA134911603; -.
DR   eggNOG; ENOG410IEPY; Eukaryota.
DR   eggNOG; ENOG410Y1BM; LUCA.
DR   GeneTree; ENSGT00390000001183; -.
DR   HOGENOM; HOG000006591; -.
DR   HOVERGEN; HBG106031; -.
DR   InParanoid; Q5T5M9; -.
DR   OMA; RHPVSEQ; -.
DR   OrthoDB; EOG091G09DD; -.
DR   PhylomeDB; Q5T5M9; -.
DR   TreeFam; TF101009; -.
DR   SignaLink; Q5T5M9; -.
DR   GenomeRNAi; 54619; -.
DR   PRO; PR:Q5T5M9; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000107443; -.
DR   CleanEx; HS_CCNJ; -.
DR   Genevisible; Q5T5M9; HS.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   Gene3D; 1.10.472.10; -; 2.
DR   InterPro; IPR028859; Cyclin-J.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177:SF300; PTHR10177:SF300; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
DR   PRODOM; Q5T5M9.
DR   SWISS-2DPAGE; Q5T5M9.
KW   Alternative splicing; Complete proteome; Cyclin; Reference proteome.
FT   CHAIN         1    372       Cyclin-J.
FT                                /FTId=PRO_0000309316.
FT   DOMAIN       15    143       Cyclin N-terminal.
FT   VAR_SEQ     193    193       Q -> QDYAFLNYAPSL (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_041163.
FT   VAR_SEQ     194    194       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_029128.
SQ   SEQUENCE   372 AA;  42581 MW;  5CCADA91E11CF5D7 CRC64;
     MELEGQWWRG QLAADIHQAL RYKELKLPSY KGQSPQLSLR RYFADLIAIV SNRFTLCPSA
     RHLAVYLLDL FMDRYDISIQ QLHLVALSCL LLASKFEEKE DSVPKLEQLN SLGCMTNMNL
     VLTKQNLLHM ELLLLETFQW NLCLPTAAHF IEYYLSEAVH ETDLHDGWPM ICLEKTKLYM
     AKYADYFLEV SLQVAAACVA SSRIILRLSP TWPTRLHRLT AYSWDFLVQC IERLLIAHDN
     DVKEANKQRG QAGPQSAQLS VFQTASQPSR PVHFQQPQYL HQTHQTSLQY RHPTSEQPSC
     QQIVSTTHTS SYTLQTCPAG FQTSVQGLGH MQTGVGMSLA IPVEVKPCLS VSYNRSYQIN
     EHYPCITPCF ER
//

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