(data stored in ACNUC23405 zone)

SWISSPROT: MNX1_MOUSE

ID   MNX1_MOUSE              Reviewed;         404 AA.
AC   Q9QZW9; E9QPC0;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   07-SEP-2016, entry version 119.
DE   RecName: Full=Motor neuron and pancreas homeobox protein 1;
DE   AltName: Full=Homeobox protein HB9;
GN   Name=Mnx1; Synonyms=Hlxb9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster / NIH;
RX   PubMed=10471502; DOI=10.1038/12674;
RA   Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H.;
RT   "Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in
RT   Hlxb9-deficient mice.";
RL   Nat. Genet. 23:71-75(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Putative transcription factor involved in pancreas
CC       development and function.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC       ProRule:PRU00108}.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00108}.
DR   EMBL; AF153046; AAD49613.1; -; mRNA.
DR   EMBL; AC164700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS19150.1; -.
DR   UniGene; Mm.103760; -.
DR   ProteinModelPortal; Q9QZW9; -.
DR   SMR; Q9QZW9; 239-300.
DR   STRING; 10090.ENSMUSP00000129503; -.
DR   iPTMnet; Q9QZW9; -.
DR   PhosphoSite; Q9QZW9; -.
DR   MaxQB; Q9QZW9; -.
DR   PaxDb; Q9QZW9; -.
DR   PRIDE; Q9QZW9; -.
DR   Ensembl; ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.
DR   MGI; MGI:109160; Mnx1.
DR   eggNOG; KOG0489; Eukaryota.
DR   eggNOG; ENOG410ZTBY; LUCA.
DR   GeneTree; ENSGT00760000118940; -.
DR   HOGENOM; HOG000234345; -.
DR   HOVERGEN; HBG051910; -.
DR   InParanoid; Q9QZW9; -.
DR   OrthoDB; EOG091G0PFO; -.
DR   PRO; PR:Q9QZW9; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   Bgee; ENSMUSG00000001566; -.
DR   CleanEx; MM_MNX1; -.
DR   ExpressionAtlas; Q9QZW9; baseline and differential.
DR   Genevisible; Q9QZW9; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IMP:MGI.
DR   GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
DR   GO; GO:0060539; P:diaphragm development; IMP:MGI.
DR   GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
DR   GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
DR   GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
DR   GO; GO:0021675; P:nerve development; IMP:MGI.
DR   GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR   GO; GO:0001764; P:neuron migration; IMP:MGI.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IMP:MGI.
DR   GO; GO:0031016; P:pancreas development; IMP:MGI.
DR   GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
DR   GO; GO:0060541; P:respiratory system development; IMP:MGI.
DR   GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IMP:MGI.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.60; -; 1.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR009057; Homeodomain-like.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9QZW9.
DR   SWISS-2DPAGE; Q9QZW9.
KW   Acetylation; Complete proteome; DNA-binding; Homeobox; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    404       Motor neuron and pancreas homeobox
FT                                protein 1.
FT                                /FTId=PRO_0000048906.
FT   DNA_BIND    241    300       Homeobox. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00108}.
FT   COMPBIAS     40     50       Poly-Gly.
FT   COMPBIAS     99    105       Poly-Gly.
FT   COMPBIAS    121    134       Poly-Ala.
FT   COMPBIAS    168    176       Poly-Ala.
FT   COMPBIAS    315    324       Poly-Gly.
FT   MOD_RES       1      1       N-acetylmethionine.
FT                                {ECO:0000250|UniProtKB:P50219}.
FT   MOD_RES      78     78       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P50219}.
FT   MOD_RES      80     80       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P50219}.
FT   CONFLICT    232    232       E -> Q (in Ref. 1; AAD49613).
FT                                {ECO:0000305}.
SQ   SEQUENCE   404 AA;  41331 MW;  1D2B56CD645DB50A CRC64;
     MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG TSSGASRSCS
     PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA GGGGGAAGGP GTPHHHAHPG
     AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYSYSAAA AAAALAGQHP
     ALSYSYPQVQ GAHPAHPADP IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK
     CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK
     KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD LRDSDPDEDE
     DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ PLPQ
//

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