(data stored in SCRATCH zone)

SWISSPROT: Q9X4P8_SALTM

ID   Q9X4P8_SALTM            Unreviewed;       341 AA.
AC   Q9X4P8;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   11-DEC-2019, entry version 97.
DE   SubName: Full=LeuO {ECO:0000313|EMBL:AAD26693.1};
GN   Name=leuO {ECO:0000313|EMBL:AAD26693.1};
OS   Salmonella typhimurium.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371 {ECO:0000313|EMBL:AAD26693.1};
RN   [1] {ECO:0000313|EMBL:AAD26693.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LT2 {ECO:0000313|EMBL:AAD26693.1};
RX   PubMed=6327652;
RA   Gemmill R.M., Tripp M., Friedman S.B., Calvo J.M.;
RT   "Promoter mutation causing catabolite repression of the Salmonella
RT   typhimurium leucine operon.";
RL   J. Bacteriol. 158:948-953(1984).
RN   [2] {ECO:0000313|EMBL:AAD26693.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LT2 {ECO:0000313|EMBL:AAD26693.1};
RX   PubMed=3519576;
RA   Haughn G.W., Wessler S.R., Gemmill R.M., Calvo J.M.;
RT   "High A + T content conserved in DNA sequences upstream of leuABCD in
RT   Escherichia coli and Salmonella typhimurium.";
RL   J. Bacteriol. 166:1113-1117(1986).
RN   [3] {ECO:0000313|EMBL:AAD26693.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LT2 {ECO:0000313|EMBL:AAD26693.1};
RX   PubMed=10931352; DOI=10.1046/j.1365-2958.2000.02015.x;
RA   El Hanafi D., Bossi L.;
RT   "Activation and silencing of leu-500 promoter by transcription-induced DNA
RT   supercoiling in the Salmonella chromosome.";
RL   Mol. Microbiol. 37:583-594(2000).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|SAAS:SAAS01096700}.
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DR   EMBL; AF117227; AAD26693.1; -; Genomic_DNA.
DR   PATRIC; fig|90371.687.peg.123; -.
DR   eggNOG; ENOG41064T2; Bacteria.
DR   eggNOG; ENOG4110BBF; LUCA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9X4P8.
DR   SWISS-2DPAGE; Q9X4P8.
KW   DNA-binding {ECO:0000256|SAAS:SAAS01096662};
KW   Transcription {ECO:0000256|SAAS:SAAS01096725};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS01096646}.
FT   DOMAIN          49..106
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   341 AA;  38879 MW;  37E70BFAA9843934 CRC64;
     MHGKSYFQEL FLPSARKREL SVTVELNMPE VKTEKPHLLD MGKPQLRMVD LNLLTVFDAV
     MQEQNITRAA HTLGMSQPAV SNAVARLKVM FNDELFVRYG RGIQPTARAF QLFGSVRQAL
     QLVQNELPGS GFEPTSSERV FNLCVCSPLD NILTSQIYNR VEKIAPNIHV VFKASLNQNT
     EHQLRYQETE FVISYEEFRR PEFTSVPLFK DEMVLVASRK HPRISGPLLE GDVYNEQHAV
     VSLDRYASFS QPWYDTPDKQ SSVAYQGMAL ISVLNVVSQT HLVAIAPRWL AEEFAESLDL
     QILPLPLKLN SRTCYLSWHE AAGRDKGHQW MEDLLVSVCK R
//

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