(data stored in ACNUC27125 zone)

SWISSPROT: COX3_KLULA

ID   COX3_KLULA              Reviewed;         269 AA.
AC   Q9XLW9; Q6DN55;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   11-DEC-2019, entry version 99.
DE   RecName: Full=Cytochrome c oxidase subunit 3;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide III;
GN   Name=COX3;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=10757749;
RA   Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D.;
RT   "Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-
RT   specific translational activators have orthologous functions in other
RT   budding yeasts.";
RL   Genetics 154:999-1012(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX   PubMed=15691736; DOI=10.1016/j.femsyr.2004.09.003;
RA   Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.;
RT   "Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces
RT   lactis.";
RL   FEMS Yeast Res. 5:315-322(2005).
CC   -!- FUNCTION: Subunits I, II and III form the functional core of the enzyme
CC       complex.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 [Fe(II)cytochrome c] + 4 H(+) + O2 = 4 [Fe(III)cytochrome c]
CC         + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA-COMP:10350, Rhea:RHEA-
CC         COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.9.3.1;
CC   -!- SUBUNIT: Composed of at least 11 subunits.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
DR   EMBL; AF120716; AAD29123.1; -; Genomic_DNA.
DR   EMBL; AY654900; AAT64954.1; -; Genomic_DNA.
DR   RefSeq; YP_054504.1; NC_006077.1.
DR   SMR; Q9XLW9; -.
DR   GeneID; 2914070; -.
DR   KEGG; kla:KllafMp08; -.
DR   HOGENOM; HOG000264954; -.
DR   InParanoid; Q9XLW9; -.
DR   KO; K02262; -.
DR   Proteomes; UP000000598; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   CDD; cd01665; Cyt_c_Oxidase_III; 1.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR033945; Cyt_c_oxase_su3_dom.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9XLW9.
DR   SWISS-2DPAGE; Q9XLW9.
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..269
FT                   /note="Cytochrome c oxidase subunit 3"
FT                   /id="PRO_0000183795"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        32
FT                   /note="S -> A (in Ref. 1; AAD29123)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  30432 MW;  77DC8D1DE2A20C8F CRC64;
     MTHLERSRHQ QFPFHLVAPS PWPIVVSFAL MSLALSLALT MHGYIGHMYL IYLSILTVTL
     SATLWFRDII AEATYLGDHT IAVRKGINLG FLLFVVSEIL IFAALFWAYF HSAMSPNIEL
     GGVWPPVGIQ AVQPTELPLL NTIILLSSGA TITYSHHGLV GGNRKNALSG LLITFWLIVI
     FVTCQYIEYT NATFTITDGV YGSVFYAGTG LHFLHMVMLA AMLGINYWRL RNYHLTATHH
     VGYETTVLYC HILDIIWLFL YIVFYWWGV
//

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