(data stored in ACNUC10043 zone)

SWISSPROT: RFCL_AERPE

ID   RFCL_AERPE              Reviewed;         479 AA.
AC   Q9YBS5;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-FEB-2004, sequence version 2.
DT   11-DEC-2019, entry version 88.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=APE_1524.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
DR   EMBL; BA000002; BAA80523.2; -; Genomic_DNA.
DR   PIR; E72633; E72633.
DR   SMR; Q9YBS5; -.
DR   STRING; 272557.APE_1524.1; -.
DR   PRIDE; Q9YBS5; -.
DR   EnsemblBacteria; BAA80523; BAA80523; APE_1524.1.
DR   KEGG; ape:APE_1524.1; -.
DR   PATRIC; fig|272557.25.peg.1027; -.
DR   eggNOG; arCOG00470; Archaea.
DR   eggNOG; COG0470; LUCA.
DR   HOGENOM; HOG000271062; -.
DR   KO; K04800; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q9YBS5.
DR   SWISS-2DPAGE; Q9YBS5.
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..479
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135947"
FT   NP_BIND         56..63
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   479 AA;  54806 MW;  0F09E390DB449456 CRC64;
     MPIVARSSRV PWVIKYRPKR VEDVVNQDQA KKILVPWFKA WLEGRKPDKR AALLYGPPGV
     GKTSLVEAIA SEFNLEMIEL NASDYRRRSD IERIVGAASR KRSMFKRGVV ILLDEVDGIN
     PREDAGGIEA LLSVIKTTEN PIVMTANDPW KDFLRPLREV SLMVEFRPLT LTHIVAVLQR
     ICEAERIECE REALRYIAER SEGDLRSAIN DLQAVAEGYG RVTLTLAREI VRGREKSIDI
     WRTLNQVFYK PRQAWMARKA VSQSEKDYEE LIAWINDNIP RKYGEPSDLF RAFDALARAT
     VFLGRAKFGG NWELLSYVFD LMGPGVAYAR MEGEVLKTRY SYPEKIRMMA QLRGVRETRE
     KLAEVLAKRL LMSRRAVKTE VLPILHYIFR SSRDPTKPAM IALEYGLTEK MVELLAGQRK
     SEILKAMATV KKARLGEKPL EPQEAKARRR GEKASRDEGR KAGKRERKGV GLDFFLGEQ
//

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