(data stored in ACNUC1130 zone)

HOVERGEN: A0M8T9_CHICK

ID   A0M8T9_CHICK            Unreviewed;      1382 AA.
AC   A0M8T9;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   03-NOV-2009, entry version 27.
DE   SubName: Full=Met proto-oncogene;
GN   Name=MET;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=22799194; PubMed=12917688; DOI=10.1038/nature01858;
RA   Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA   Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA   Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA   Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.,
RA   Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B.,
RA   Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E.,
RA   Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K.,
RA   Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J.,
RA   Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R.,
RA   Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C.,
RA   Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C.,
RA   Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C.,
RA   Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J.,
RA   Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P.,
RA   Miller W., Green E.D.;
RT   "Comparative analyses of multi-species sequences from targeted genomic
RT   regions.";
RL   Nature 424:788-793(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Green E.D.;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; DP000235; AAR16242.1; -; Genomic_DNA.
DR   IPI; IPI00818723; -.
DR   UniGene; Gga.669; -.
DR   SMR; A0M8T9; 1047-1347.
DR   STRING; A0M8T9; -.
DR   Ensembl; ENSGALT00000015300; ENSGALP00000015284; ENSGALG00000009390; Gallus gallus.
DR   Ensembl; ENSGALT00000038938; ENSGALP00000038148; ENSGALG00000009390; Gallus gallus.
DR   HOVERGEN; A0M8T9; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004872; F:receptor activity; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR016201; Plexin-like_fold.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR020707; Tyr_kinase_hepatocyte_GF_rcpt.
DR   InterPro; IPR008266; Tyr_prot_kinase_AS.
DR   InterPro; IPR001245; Tyr_prot_kinase_cat_dom.
DR   InterPro; IPR016244; Tyr_prot_kinase_HGF/MSP_rcpt.
DR   InterPro; IPR020635; Tyr_prot_kinase_subgr_cat_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   PANTHER; PTHR23256:SF169; Tyr_kinase_hepatocyte_GF_rcpt; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0M8T9.
DR   SWISS-2DPAGE; A0M8T9.
KW   ATP-binding; Membrane; Nucleotide-binding; Transmembrane;
KW   Tyrosine-protein kinase.
SQ   SEQUENCE   1382 AA;  154400 MW;  35A7292B629724D5 CRC64;
     MKPVTAYPSG IILFLFALLQ RSHGQCKEAA KKSEMNLNVK YDLPNFITET PIQNVVLYKH
     HVYIGAVNKI YVLNETLQNI SVYKTGPILE SPGCAPCEDC KDKANLSNSV WKDNVNMALL
     LETYYDDQLI SCGSVSGGVC HRHIIPPDNP ADIESEVHCM YSPQVDGEAD NCPDCVVSTL
     GTKVLVTEKD RFVNFFVGNT VTSAFQPPHV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ
     FRDSYPIKYV HAFEHDHFVY FLTVQRESLD SQTFHTRIIR FCTLDSEMRS YMEMPLECIF
     TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLNDD ILYGVFAQSK PDSSEPTNRS
     AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKDSKYCLNR AFSRNASYCR AQDDEYRLEV
     TTPLQRVDLF MGQFNNILLT SISVFTKGNL TIANLGTSEG RFMQIVVSRS EPTAPHVSFQ
     LDSHAVSPQV VVEQSAAADG YTLVVTGKKI TKVPLNGPGC HHFQSCSQCL LAPAFMRCGW
     CGQQCLRAPE CNGGTWTQET CLPRVYEILP SSAPLEGGTK LTLCGWDFGF SKNNRFELRN
     TVVHIGGQIC ALEAKSSNKN KLECTAPAAK NASFNISSSV SVGHGKTLFN TFSYVNPIIT
     SISPTYGPKS GGTLLTIAGK YLNSGKSRRI FVGEKPCSLK STSESSVECY TPAQRIPQEY
     RVRVGIDGAI RDAKGYFTYR EDPVVLKIHP AKSFLSGGST ITAQGINLNS VCFPRMVITV
     PKLGMNFSVA CSHRSSSEII CCTTPSLKAF NLQPPFVTKV FFIFDGVSSL YFDFDYVNNP
     VFKHFEKPVL ISRSNPNVLE IKGNHIDSEA VKGEVLKVGN KSCENLLLQS ETILCTVPSD
     LLKSNSELNI EWKQEVLSTV IGKVLIRQDQ NFTGLIAGVV STSVLIFIFL VFFLWRRKKK
     QIKDLGSDLV RYDGRVHTPH LDRLVSARSV SPTTEMVSSE SVDYRSTFLE DQFPSMSQNG
     SCRPAQYPHS DLSPILSSGD SDLASPLLQT NVHIDISALN PDLVKEVQHV VIGADSLMVH
     FSEVIGRGHF GCVYHGTLLD NDGRKIHCAV KSLNRITDLE EVAQFLKEGI IMKDFTHPNV
     LSLLGICLPN EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
     FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK
     FTTKSDVWSF GVLLWELMTR GAPPYPDVNS FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
     WHPKPEMRPA FSELVSKIST IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNTDMDV
     DT
//

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