(data stored in ACNUC4932 zone)

HOVERGEN: A2AFM9_MOUSE

ID   A2AFM9_MOUSE            Unreviewed;       448 AA.
AC   A2AFM9;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   03-NOV-2009, entry version 25.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1;
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2,6-biphosphata se 1;
GN   Name=Pfkfb1; ORFNames=RP23-338A17.2-001;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Humphries M.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; BC132561; AAI32562.1; -; mRNA.
DR   EMBL; BC132563; AAI32564.1; -; mRNA.
DR   EMBL; AL672150; CAM21427.1; -; Genomic_DNA.
DR   IPI; IPI00653772; -.
DR   RefSeq; NP_032850.1; -.
DR   UniGene; Mm.249131; -.
DR   SMR; A2AFM9; 19-447.
DR   STRING; A2AFM9; -.
DR   PRIDE; A2AFM9; -.
DR   Ensembl; ENSMUST00000080884; ENSMUSP00000079692; ENSMUSG00000025271; Mus musculus.
DR   Ensembl; ENSMUST00000112713; ENSMUSP00000108333; ENSMUSG00000025271; Mus musculus.
DR   GeneID; 18639; -.
DR   KEGG; mmu:18639; -.
DR   CTD; 18639; -.
DR   MGI; MGI:107816; Pfkfb1.
DR   HOVERGEN; A2AFM9; -.
DR   NextBio; 294618; -.
DR   Bgee; A2AFM9; -.
DR   Genevestigator; A2AFM9; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Compara.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; A2AFM9.
DR   SWISS-2DPAGE; A2AFM9.
KW   Kinase.
SQ   SEQUENCE   448 AA;  52112 MW;  6CF417A9F775B167 CRC64;
     MEEKASKRAA SIPQFTNSPT MVIMVGLPAR GKTYISTKLT RYLNWIGTPT KVFNLGQYRR
     EAVSYRNYEF FRPDNMEAQL IRKQCALAAL KDVHKYLSRE EGHVAVFDAT NTTRERRSLI
     LQFAKEHGYK VFFIESICND PDIIAENIKQ VKLGSPDYID CDQEKVLEDF LKRIECYEIN
     YQPLDEELDS HLSYIKIFDV GTRYMVNRVQ DHVQSRTAYY LMNIHVTPRS IYLCRHGESE
     LNLRGRIGGD SGLSARGKQY AYALANFIRS QSISSLKVWT SHMKRTIQTA EALGVPYEQW
     KALNEIDAGV CEEMTYEEIQ EHYPEEFALR DQDKYRYRYP KGESYEDLVQ RLEPVIMELE
     RQENVLVICH QAVMRCLLAY FLDKSSDELP YLKCPLHTVL KLTPVAYGCR VESIYLNVEA
     VNTHRDKPEN VDITREPEEA LDTVPAHY
//

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