(data stored in ACNUC4932 zone)

HOVERGEN: A7UAK5_MOUSE

ID   A7UAK5_MOUSE            Unreviewed;       555 AA.
AC   A7UAK5;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   03-NOV-2009, entry version 17.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2;
DE            EC=2.7.1.105;
DE            EC=3.1.3.46;
GN   Name=Pfkfb3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6;
RX   PubMed=14623077; DOI=10.1016/S0014-5793(03)01179-7;
RA   Minchenko O.H., Opentanova I.L., Caro J.;
RT   "Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-
RT   bisphosphatase gene family (PFKFB-1-4) expression in vivo.";
RL   FEBS Lett. 554:264-270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6;
RA   Minchenko O.H., Tsuchihara K., Minchenko D.O., Bobarykina A.Y.,
RA   Mykhalchenko V.G., Esumi H.;
RT   "Unique splice variant of PFKFB-3 mRNA in mice: hypoxic regulation of
RT   its expression.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; EU034676; ABS88613.1; -; mRNA.
DR   IPI; IPI00653570; -.
DR   UniGene; Mm.19669; -.
DR   STRING; A7UAK5; -.
DR   Ensembl; ENSMUST00000028114; ENSMUSP00000028114; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000049849; ENSMUSP00000050926; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000091464; ENSMUSP00000089043; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000100411; ENSMUSP00000097979; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000114844; ENSMUSP00000110493; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000114845; ENSMUSP00000110494; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000114846; ENSMUSP00000110495; ENSMUSG00000026773; Mus musculus.
DR   MGI; MGI:2181202; Pfkfb3.
DR   Bgee; A7UAK5; -.
DR   Genevestigator; A7UAK5; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase act...; IEA:EC.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; A7UAK5.
DR   SWISS-2DPAGE; A7UAK5.
KW   Hydrolase; Kinase; Transferase.
SQ   SEQUENCE   555 AA;  63653 MW;  89E9DFC05B01E508 CRC64;
     MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN
     WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMRVRK QCALAALRDV KSYLTKEGGQ
     IAVFDATNTT RERRHMILNF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS
     AEAMDDFMKR INCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM
     NIHVQPRTIY LCRHGENEYN LQGKIGGDSG LSSRGKKFAN ALSKFVEEQN LKDLRVWTSQ
     LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG
     ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL
     TPVAYGCRVE SIYLNVESVS THRERSEAVK IQHFASVVRP SSYTELDFQS VESAKQDAKK
     GPNPLMRRNS VTPLASPEPT KKPRINSFEE RVASTSAALP SCLPPEVPTQ LPGQPLLGKA
     CLRSVCHIFS KFSPY
//

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