(data stored in ACNUC27125 zone)

HOGENOM: ACAM1_1_PE1133

ID   ACAM1_1_PE1133                       STANDARD;      PRT;   675 AA.
AC   ACAM1_1_PE1133; B0C308;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA ligase; EC=6.5.1 2;AltName:
DE   Full=Polydeoxyribonucleotide synthase (ACAM1_1.PE1133) [NAD+]; .
GN   Name=ligA; OrderedLocusNames=AM1_1187;
OS   ACARYOCHLORIS MARINA MBIC11017.
OC   Bacteria; Cyanobacteria; Acaryochloris.
OX   NCBI_TaxID=329726;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACAM1_1.PE1133.
CC       Acaryochloris marina MBIC11017, complete genome.
CC   -!- ANNOTATIONS ORIGIN:DNLJ_ACAM1
CC   -!- FUNCTION: DNA ligase that catalyzes the formation of
CC       phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl
CC       groups in double-stranded DNA using NAD as a coenzyme and as the
CC       energy source for the reaction. It is essential for DNA
CC       replication and repair of damaged DNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigA
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 BRCT domain.
CC   -!- GENE_FAMILY: HOG000218459 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B0C308; -.
DR   EMBL; CP000828; ABW26224.1; -; Genomic_DNA.
DR   RefSeq; YP_001515538.1; NC_009925.1.
DR   ProteinModelPortal; B0C308; -.
DR   SMR; B0C308; 6-324.
DR   STRING; B0C308; -.
DR   GeneID; 5680010; -.
DR   GenomeReviews; CP000828_GR; AM1_1187.
DR   KEGG; amr:AM1_1187; -.
DR   OMA; ENVRTIR; -.
DR   ProtClustDB; PRK07956; -.
DR   BioCyc; AMAR329726:AM1_1187-MON; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003911; F:DNA ligase (NAD+) activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01588; DNA_ligase_A; 1; -.
DR   InterPro; IPR001357; BRCT.
DR   InterPro; IPR018239; DNA_ligase_AS.
DR   InterPro; IPR004150; DNA_ligase_OB.
DR   InterPro; IPR001679; DNAligase.
DR   InterPro; IPR013839; DNAligase_adenylation.
DR   InterPro; IPR013840; DNAligase_N.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004149; Znf_DNAligase_C4.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF01653; DNA_ligase_aden; 1.
DR   Pfam; PF03120; DNA_ligase_OB; 1.
DR   Pfam; PF03119; DNA_ligase_ZBD; 1.
DR   PIRSF; PIRSF001604; LigA; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SMART; SM00278; HhH1; 3.
DR   SMART; SM00532; LIGANc; 1.
DR   SUPFAM; SSF52113; BRCT; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   SUPFAM; SSF47781; RuvA_2_like; 1.
DR   TIGRFAMs; TIGR00575; Dnlj; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS01055; DNA_LIGASE_N1; 1.
DR   PROSITE; PS01056; DNA_LIGASE_N2; 1.
DR   HOGENOMDNA; ACAM1_1.PE1133; -.
KW   NAD-dependent DNA ligase LigA;
KW   Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;
KW   Magnesium; Manganese; Metal-binding; NAD; Zinc.
SQ   SEQUENCE   675 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNTVSSSDQA RVQELRQLLQ KASYAYYGLD APLMEDAVYD QLYHELVDLE AQYPQLITPD
     SPTQRVGERP ATQFVSVQHR IPLYSLENAF DRGDMDTWDE RWHKLVPNLS QEPGYVTELK
     IDGSALALTY ENGLLVRGTT RGDGTKGEEI TQNVRTIRSI PLRLNIEHPP EWLEVRGEAF
     LGLQVFDQIN RDRIQAGEAE FANPRNAAAG TLRQLDSKVV AERKLDFFAY TIHISGPTDD
     LALPQTQWQA LETLKQLGFR VNPNRRQCES LAEVQTYYDD WSLKRLDLPY LTDGVVIKLD
     NLGVQDELGF TQKFPRWAIA WKYPPEEAAT RIEQITVNVG RTGALTPVAE FKPVQLAGTT
     VSRATLHNRD RISELDIHIG DTVVVRKAGE IIPEVLRVLP ELRPAGAQPY QMPTACPSCG
     QPAVQLETEA VTRCVNASCP AILRGSLIHW VSRGALDIDG LGEKIVGQLT DSQMVQSVAD
     LYELNEDKLM DLDRMGTKLA RKIVSAIATS KQQPWHRVLY GLGIRHVGSV NAQLLTENYP
     TVDALMAVDG DKIATIHGIG PEIAQSVYEW FQTPTNQTLI QRLQSAGLQF EAIVSESTQP
     QTLSGKTFVI TGTLPTLKRD QAKQMIQDAG GKVTGSVSKN TSYVVVGADA GSKLTKAQSL
     GINQLSEADL LALLQ
//

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