(data stored in ACNUC7421 zone)

HOGENOM: ACAM1_1_PE610

ID   ACAM1_1_PE610                        STANDARD;      PRT;   332 AA.
AC   ACAM1_1_PE610; B0CE67;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3; EC=2.3.1
DE   180;AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III;AltName:
DE   Full=Beta-ketoacyl-ACP synthase III; Short=KAS III; (ACAM1_1.PE610).
GN   Name=fabH; OrderedLocusNames=AM1_0653;
OS   ACARYOCHLORIS MARINA MBIC11017.
OC   Bacteria; Cyanobacteria; Acaryochloris.
OX   NCBI_TaxID=329726;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACAM1_1.PE610.
CC       Acaryochloris marina MBIC11017, complete genome.
CC   -!- ANNOTATIONS ORIGIN:FABH_ACAM1
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP. Catalyzes the first condensation reaction which
CC       initiates fatty acid synthesis and may therefore play a role in
CC       governing the total rate of fatty acid production. Possesses both
CC       acetoacetyl-ACP synthase and acetyl transacylase activities. Its
CC       substrate specificity determines the biosynthesis of branched-
CC       chain and/or straight-chain of fatty acids (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + malonyl-[acyl-carrier-protein] =
CC       acetoacetyl-[acyl-carrier-protein] + CoA + CO(2).
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- DOMAIN: The last Arg residue of the ACP-binding site is essential
CC       for the weak association between ACP/AcpP and FabH (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the fabH family.
CC   -!- GENE_FAMILY: HOG000246674 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B0CE67; -.
DR   EMBL; CP000828; ABW25701.1; -; Genomic_DNA.
DR   RefSeq; YP_001515015.1; NC_009925.1.
DR   ProteinModelPortal; B0CE67; -.
DR   STRING; B0CE67; -.
DR   GeneID; 5679481; -.
DR   GenomeReviews; CP000828_GR; AM1_0653.
DR   KEGG; amr:AM1_0653; -.
DR   OMA; KEIGAIN; -.
DR   BioCyc; AMAR329726:AM1_0653-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01815; FabH; 1; -.
DR   InterPro; IPR013751; ACP_syn_III.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004655; FabH_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   Pfam; PF08545; ACP_syn_III; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   TIGRFAMs; TIGR00747; FabH; 1.
DR   HOGENOMDNA; ACAM1_1.PE610; -.
KW   3-oxoacyl-[acyl-carrier-protein] synthase 3;
KW   Acyltransferase; Complete proteome; Cytoplasm;
KW   Fatty acid biosynthesis; Lipid synthesis; Multifunctional enzyme;
KW   Transferase.
SQ   SEQUENCE   332 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQQMATGLAV TGCGSAAPET SLDNHGLSQI VDTSDEWIAS RTGIRSRHLA GPDDTLAKLG
     AIAAQNALEM AQVEATDLDL ILLATSTPDD LFGSACQIQA AIGAKHAVAF DLTAACSGFV
     FGMITAAQFI RTGVYRNVLL VGADVLSRWV DWTDRRSCVL FGDGAGAVVL QANDTDRLLG
     FALHSDGCLH DCLNVQYQGE ARPLTGEINV SQGTYQPISM NGKEVYRFAV NRVPEVVEKA
     LFQSDLKTDD IDWLLLHQAN QRILDAVAKR LKVPAEKVIS NIANYGNTSA ATIPLALDAT
     VRKGHIKPGD TIAASGFGAG LSWGAAIFQW QR
//

If you have problems or comments...

PBIL Back to PBIL home page