(data stored in ACNUC7421 zone)

HOGENOM: ACIAC_1_PE1144

ID   ACIAC_1_PE1144                       STANDARD;      PRT;   281 AA.
AC   ACIAC_1_PE1144; A1TLC4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=NADPH-dependent 7-cyano-7-deazaguanine reductase; EC=1.7.1
DE   13;AltName: Full=7-cyano-7-carbaguanine reductase;AltName:
DE   Full=NADPH-dependent nitrile oxidoreductase;AltName: Full=PreQ(0)
DE   reductase; (ACIAC_1.PE1144).
GN   Name=queF; OrderedLocusNames=Aave_1170;
OS   ACIDOVORAX CITRULLI AAC00-1.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=397945;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACIAC_1.PE1144.
CC       Acidovorax avenae subsp. citrulli AAC00-1, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:QUEF_ACIAC
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of 7-cyano-7-
CC       deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-
CC       cyano-7-carbaguanine + 2 NADPH.
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family. QueF type
CC       2 subfamily.
CC   -!- GENE_FAMILY: HOG000273755 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A1TLC4; -.
DR   EMBL; CP000512; ABM31762.1; -; Genomic_DNA.
DR   RefSeq; YP_969536.1; NC_008752.1.
DR   ProteinModelPortal; A1TLC4; -.
DR   SMR; A1TLC4; 15-281.
DR   STRING; A1TLC4; -.
DR   GeneID; 4665187; -.
DR   GenomeReviews; CP000512_GR; Aave_1170.
DR   KEGG; aav:Aave_1170; -.
DR   NMPDR; fig|397945.5.peg.1021; -.
DR   eggNOG; COG0780; -.
DR   OMA; CVERIFC; -.
DR   PhylomeDB; A1TLC4; -.
DR   ProtClustDB; PRK11792; -.
DR   BioCyc; AAVE397945:AAVE_1170-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046857; F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as accDR   GO; GO:0033739; F:preQ1 synthase activity; IEA:EC.
DR   GO; GO:0033739; F:preQ1 synthase activity; IEA:EC.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00817; QueF_type2; 1; -.
DR   InterPro; IPR016428; CN_OxRdtase_NADPH-dep_YqcD.
DR   InterPro; IPR020602; GTP_CycHdrlase_I/CN_OxRdtase.
DR   Pfam; PF01227; GTP_cyclohydroI; 1.
DR   PIRSF; PIRSF004750; Nitrile_oxidored_YqcD_prd; 1.
DR   TIGRFAMs; TIGR03138; QueF; 1.
DR   HOGENOMDNA; ACIAC_1.PE1144; -.
KW   7-cyano-7-deazaguanine reductase;
KW   Complete proteome; Cytoplasm; NADP; Oxidoreductase;
KW   Queuosine biosynthesis.
SQ   SEQUENCE   281 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNTPDQSQLG RVSGYADQYD ASLLFPLPRQ PKRHEIGVTG TPPFFGADLW TAFELSWLNL
     RGKPQVALAH ITVPCETPNI IESKSFKLYL NSFNNTRFAD AAQVQTRIRT DISEAAWRGS
     DRQATVGVKL VLPEMFDREP VQELDGLLLD RLDVECTHYT PAPELLHANH GEAPVTETLT
     SHLLKSNCLV TGQPDWGSVR IEYSGAQIDQ SGLLRYLVSF RNHNEFHEQC VERIFMDLWT
     RCRPIKLSVY ARYTRRGGLD INPLRTSHPQ ALPANVRTAR Q
//

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