(data stored in ACNUC15324 zone)

HOGENOM: ACIAD_1_PE1321

ID   ACIAD_1_PE1321                       STANDARD;      PRT;   303 AA.
AC   ACIAD_1_PE1321; P07774; Q43930;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=HTH-type transcriptional regulator CatM;AltName: Full=Cat
DE   operon transcriptional regulator; (ACIAD_1.PE1321).
GN   Name=catM; Synonyms=catR; OrderedLocusNames=ACIAD1445;
OS   ACINETOBACTER SP. ADP1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACIAD_1.PE1321.
CC       Acinetobacter sp. ADP1 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:CATM_ACIAD
CC   -!- FUNCTION: Positively regulates the expression of catA, catBCIJFD
CC       and benPK in response to cis,cis-muconate. It binds to the catB-
CC       catM intercistronic region, to a specific sequence upstream of
CC       catA and to the benPK promoter region. Can also repress pca genes.
CC   -!- SUBUNIT: Homotetramer in solution.
CC   -!- INDUCTION: Negatively autoregulated.
CC   -!- SIMILARITY: Contains 1 HTH lysR-type DNA-binding domain.
CC   -!- CAUTION: Was originally (PubMed:2793826) reported to be a
CC       transcriptional repressor of cat genes. However, further
CC       investigations have shown it to be a transcriptional activator.
CC   -!- GENE_FAMILY: HOG000233514 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P07774; Q43930; -.
DR   EMBL; AF009224; AAC46429.1; -; Genomic_DNA.
DR   EMBL; CR543861; CAG68308.1; -; Genomic_DNA.
DR   RefSeq; YP_046130.1; NC_005966.1.
DR   PDB; 2F7B; X-ray; 1.90 A; A=81-303.
DR   PDB; 2F7C; X-ray; 2.16 A; A=81-303.
DR   PDB; 2H98; X-ray; 1.80 A; A/B=1-303.
DR   PDB; 3GLB; X-ray; 2.80 A; A/B/C/D=89-303.
DR   PDBsum; 2F7B; -.
DR   PDBsum; 2F7C; -.
DR   PDBsum; 2H98; -.
DR   PDBsum; 3GLB; -.
DR   ProteinModelPortal; P07774; -.
DR   SMR; P07774; 89-303.
DR   STRING; P07774; -.
DR   GeneID; 2879926; -.
DR   GenomeReviews; CR543861_GR; ACIAD1445.
DR   KEGG; aci:ACIAD1445; -.
DR   NMPDR; fig|62977.3.peg.802; -.
DR   eggNOG; COG0583; -.
DR   OMA; EDASIRR; -.
DR   PhylomeDB; P07774; -.
DR   ProtClustDB; CLSK736889; -.
DR   BioCyc; ASP62977:ACIAD1445-MON; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   PROSITE; PS50931; HTH_LYSR; 1.
DR   HOGENOMDNA; ACIAD_1.PE1321; -.
KW   transcription regulator LysR;
KW   3D-structure; Activator; Aromatic hydrocarbons catabolism;
KW   Complete proteome; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
SQ   SEQUENCE   303 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MELRHLRYFV TVVEEQSISK AAEKLCIAQP PLSRQIQKLE EELGIQLFER GFRPAKVTEA
     GMFFYQHAVQ ILTHTAQASS MAKRIATVSQ TLRIGYVSSL LYGLLPEIIY LFRQQNPEIH
     IELIECGTKD QINALKQGKI DLGFGRLKIT DPAIRRIVLH KEQLKLAIHK HHHLNQFAAT
     GVHLSQIIDE PMLLYPVSQK PNFATFIQSL FTELGLVPSK LTEIREIQLA LGLVAAGEGV
     CIVPASAMDI GVKNLLYIPI LDDDAYSPIS LAVRNMDHSN YIPKILACVQ EVFATHHIRP
     LIE
//

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