(data stored in ACNUC7421 zone)

HOGENOM: ACIAD_1_PE304

ID   ACIAD_1_PE304                        STANDARD;      PRT;   717 AA.
AC   ACIAD_1_PE304; Q6FF68;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Fatty acid oxidation complex subunit alpha;Includes:
DE   RecName: Full=Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
DE   isomerase/3-hydroxybutyryl-CoA epimerase; EC=4.2.1.17; EC=5.1.2.3;
DE   EC=5.3.3.8;Includes: RecName: Full=3-hydroxyacyl-CoA dehydrogenase;
DE   EC=1.1.1 35; (ACIAD_1.PE304).
GN   Name=fadB; OrderedLocusNames=ACIAD0335;
OS   ACINETOBACTER SP. ADP1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACIAD_1.PE304.
CC       Acinetobacter sp. ADP1 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:FADB_ACIAD
CC   -!- FUNCTION: Catalyzes the formation of an hydroxyacyl-CoA by
CC       addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA
CC       epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
CC       + NADH.
CC   -!- CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-
CC       CoA + H(2)O.
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxybutanoyl-CoA = (R)-3-
CC       hydroxybutanoyl-CoA.
CC   -!- CATALYTIC ACTIVITY: (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-
CC       CoA.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains (fadB) and two beta
CC       chains (fadA) (By similarity).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the 3-
CC       hydroxyacyl-CoA dehydrogenase family.
CC   -!- GENE_FAMILY: HOG000261344 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6FF68; -.
DR   EMBL; CR543861; CAG67289.1; -; Genomic_DNA.
DR   RefSeq; YP_045111.1; NC_005966.1.
DR   ProteinModelPortal; Q6FF68; -.
DR   SMR; Q6FF68; 1-717.
DR   STRING; Q6FF68; -.
DR   GeneID; 2881154; -.
DR   GenomeReviews; CR543861_GR; ACIAD0335.
DR   KEGG; aci:ACIAD0335; -.
DR   NMPDR; fig|62977.3.peg.812; -.
DR   eggNOG; COG1250; -.
DR   OMA; FGEQKAF; -.
DR   PhylomeDB; Q6FF68; -.
DR   ProtClustDB; PRK11730; -.
DR   BioCyc; ASP62977:ACIAD0335-MON; -.
DR   GO; GO:0016507; C:fatty acid beta-oxidation multienzyme complex; IEA:InterPro.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:EC.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IEA:EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:EC.
DR   GO; GO:0009062; P:fatty acid catabolic process; IEA:InterPro.
DR   HAMAP; MF_01621; FadB; 1; -.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR001753; Crotonase_core.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR012799; FadB.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 2.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH; 1.
DR   SUPFAM; SSF48179; 6DGDH_C_like; 2.
DR   TIGRFAMs; TIGR02437; FadB; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR   HOGENOMDNA; ACIAD_1.PE304; -.
KW   Complete proteome; Fatty acid metabolism; Isomerase;
KW   Lipid degradation; Lipid metabolism; Lyase; Multifunctional enzyme;
KW   NAD; Oxidoreductase.
SQ   SEQUENCE   717 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIHAGNAITV QMLSDGIAEF RFDLQGESVN KFNRATIEDF QAAIEAVKNH PEVKGLIVTS
     AKSTFIVGAD ITEFGQNFAQ GEKAIVEWAL PVHDIFNSFE DLDIPKVAAI NGMALGGGFE
     MCLVCDYRVM SDQAQVGLPE IKLGIFPGFG GTVRLSRLIG IDNAVEWIAM AAPKKPAAAL
     KDGAVDAVVS ADKLQEAAID LVKQALAGRV DWKAKRQEKL NPVKLNPLEQ MMAFNTAKGA
     VLAKANPAQY PAPKLMLDSL QAGASLGRDE ALKVETEGFA KAAITPQAEA LIGLFLNDQI
     IKKTSKKHEK GAHPVNQAAV LGAGIMGGGI AYQAASKGTP IIMKDIGNPQ LALGMQEANG
     LLTKQVERKK LTPAKMGETL ARIRPTLSYD EFKEVDIVIE AVTENPKIKE AVLADTEAKV
     RDNTIIASNT STISITRLAK ALKRPENFVG MHFFNPVHMM PLVEVIRGEQ TSEEAVATTV
     VLAQKMGKTP IVVNDCPGFL VNRVLFPYFG AFDLLLKDGA DFQQIDKVME KFGWPMGPAY
     LMDVVGIDTG VHGAEVMAEG FPDRMKPDYK GSIQTMYEAK RLGQKNDVGF YKYELDKKGK
     KAKTVDSTAY EVIAPVVTSE KREFDAQEII DRMMLALCNE TVRCLEDNIV ATPAEADMAM
     IMGIGFPPFR GGPCRYIDQT GVAEYVALCN KYAHLGKAYE APQLLRDMAE NNKKFYG
//

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