(data stored in ACNUC7421 zone)

HOGENOM: ACIB3_1_PE3163

ID   ACIB3_1_PE3163                       STANDARD;      PRT;   717 AA.
AC   ACIB3_1_PE3163; B7H1I0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Fatty acid oxidation complex subunit alpha;Includes:
DE   RecName: Full=Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
DE   isomerase/3-hydroxybutyryl-CoA epimerase; EC=4.2.1.17; EC=5.1.2.3;
DE   EC=5.3.3.8;Includes: RecName: Full=3-hydroxyacyl-CoA dehydrogenase;
DE   EC=1.1.1 35; (ACIB3_1.PE3163).
GN   Name=fadB; OrderedLocusNames=ABBFA_003230;
OS   ACINETOBACTER BAUMANNII AB307-0294.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii
OC   complex.
OX   NCBI_TaxID=557600;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACIB3_1.PE3163.
CC       Acinetobacter baumannii AB307-0294, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:FADB_ACIB3
CC   -!- FUNCTION: Catalyzes the formation of an hydroxyacyl-CoA by
CC       addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA
CC       epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
CC       + NADH.
CC   -!- CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-
CC       CoA + H(2)O.
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxybutanoyl-CoA = (R)-3-
CC       hydroxybutanoyl-CoA.
CC   -!- CATALYTIC ACTIVITY: (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-
CC       CoA.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains (fadB) and two beta
CC       chains (fadA) (By similarity).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the 3-
CC       hydroxyacyl-CoA dehydrogenase family.
CC   -!- GENE_FAMILY: HOG000261344 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B7H1I0; -.
DR   EMBL; CP001172; ACJ56671.1; -; Genomic_DNA.
DR   RefSeq; YP_002327111.1; NC_011595.1.
DR   ProteinModelPortal; B7H1I0; -.
DR   SMR; B7H1I0; 1-717.
DR   STRING; B7H1I0; -.
DR   GeneID; 7060588; -.
DR   GenomeReviews; CP001172_GR; ABBFA_003230.
DR   KEGG; abb:ABBFA_003230; -.
DR   OMA; FGEQKAF; -.
DR   ProtClustDB; PRK11730; -.
DR   GO; GO:0016507; C:fatty acid beta-oxidation multienzyme complex; IEA:InterPro.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:EC.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IEA:EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:EC.
DR   GO; GO:0009062; P:fatty acid catabolic process; IEA:InterPro.
DR   HAMAP; MF_01621; FadB; 1; -.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR001753; Crotonase_core.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR012799; FadB.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 2.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH; 1.
DR   SUPFAM; SSF48179; 6DGDH_C_like; 2.
DR   TIGRFAMs; TIGR02437; FadB; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR   HOGENOMDNA; ACIB3_1.PE3163; -.
KW   Complete proteome; Fatty acid metabolism; Isomerase;
KW   Lipid degradation; Lipid metabolism; Lyase; Multifunctional enzyme;
KW   NAD; Oxidoreductase.
SQ   SEQUENCE   717 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIHAGNAITV QMLADGIAEF RFDLQGESVN KFNRATIEDF KAAIAAVKAN NDIKGLVVTS
     GKSTFIVGAD ITEFGQNFAQ GEKAIVDWLM PVHEIFNSFE DLDLPKVAAI NGMALGGGFE
     MCLVCDYRVM SEAAQVGLPE IKLGIYPGFG GSVRLSRLIG IDNAVEWMAM ATPKKPAAAL
     KDGAVDAVVA ADKLLDAATD LVKQAISGRL NWKAKRQEKL EAVKLNPLEQ MMAFNTAKGA
     VLAKANPAQY PAPKLLLDSL QAGASLARDE ALKAEAEGFA KAAVTPQAEA LIGLFINDQV
     VKKASKQHEK GAHPVNQAAV LGAGIMGGGI AYQAASKGTP IIMKDIGNPQ LALGMKEANN
     LLTKQVERKK MKPVQMGETL ARIRPTLSYE EFKEVDIVIE AVTENPKVKE IVLAETEKNV
     RENTIIASNT STISITRLAK ALQRPENFVG MHFFNPVHMM PLVEVIRGEK TSEEAIATTV
     VLAQKMGKTP IVVNDCPGFL VNRVLFPYFG AFDLLVKDGA DFQQIDNVMS KFGWPMGPAY
     LIDVVGIDTG VHGAEVMAEG FPDRMKPDYK GAIEAMYEAK RLGQKNDVGF YKYELDKKGK
     KAKTVDPTAY EVIAPFVTGE KREFDNQEII DRMMLALCNE TVRCLEDNIV ATASEADMAM
     IMGIGFPPFR GGPCRYIDQT GVAEYVALCD KYAHLGKAYE APQMLRDMAA NNKKFYG
//

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