(data stored in SCRATCH zone)

HOGENOM: ACIF5_1_PE1009

ID   ACIF5_1_PE1009                       STANDARD;      PRT;   195 AA.
AC   ACIF5_1_PE1009; B5EQ26;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Orotate phosphoribosyltransferase; Short=OPRT;
DE   Short=OPRTase; EC=2.4.2 10; (ACIF5_1.PE1009).
GN   Name=pyrE; OrderedLocusNames=Lferr_1029;
OS   ACIDITHIOBACILLUS FERROOXIDANS ATCC 53993.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=380394;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACIF5_1.PE1009.
CC       Acidithiobacillus ferrooxidans ATCC 53993 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:PYRE_ACIF5
CC   -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from
CC       5-phosphoribose 1-diphosphate to orotate, leading to the formation
CC       of orotidine monophosphate (OMP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Orotidine 5'-phosphate + diphosphate = orotate
CC       + 5-phospho-alpha-D-ribose 1-diphosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from orotate: step 1/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine
CC       phosphoribosyltransferase family. PyrE subfamily.
CC   -!- GENE_FAMILY: HOG000059806 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B5EQ26; -.
DR   EMBL; CP001132; ACH83271.1; -; Genomic_DNA.
DR   RefSeq; YP_002219478.1; NC_011206.1.
DR   ProteinModelPortal; B5EQ26; -.
DR   STRING; B5EQ26; -.
DR   GeneID; 6876998; -.
DR   GenomeReviews; CP001132_GR; Lferr_1029.
DR   KEGG; afe:Lferr_1029; -.
DR   OMA; FYLQSAK; -.
DR   ProtClustDB; CLSK2407751; -.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:EC.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   GO; GO:0019856; P:pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01208; PyrE; 1; -.
DR   InterPro; IPR023031; Orotate_PribosylTferase.
DR   InterPro; IPR006273; Orotate_PRibTrfase_thermus-typ.
DR   InterPro; IPR000836; PRibTrfase.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   TIGRFAMs; TIGR01367; PyrE_Therm; 1.
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; FALSE_NEG.
DR   HOGENOMDNA; ACIF5_1.PE1009; -.
KW   orotate phosphoribosyltransferase;
KW   Complete proteome; Glycosyltransferase; Magnesium;
KW   Pyrimidine biosynthesis; Transferase.
SQ   SEQUENCE   195 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTADEVVALY KEDGALLHGH FLLSSGLHSD TYLQSARVLQ YPGHAARLCA AMVAGIPDDL
     RRRISCVVGP AMGAVLVSYE CGRALGVRSL FTEREAGQMV LRRGFVLAPG EGVLVVEDIT
     TTGGSTRECM AAVTAAGGQV LAASAIIDRS SGFSDFDGAP FFPLLKLPVL TWEAAACPLC
     AAGGTPVKPG SRGLS
//

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