(data stored in ACNUC30567 zone)

HOGENOM: ACIFV_1_PE1759

ID   ACIFV_1_PE1759                       STANDARD;      PRT;   477 AA.
AC   ACIFV_1_PE1759; P11569; D2RM67; Q44043;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=(R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha;
DE   EC=4.2.1 -; (ACIFV_1.PE1759).
GN   Name=hgdA; OrderedLocusNames=Acfer_1815;
OS   ACIDAMINOCOCCUS FERMENTANS DSM 20731.
OC   Bacteria; Firmicutes; Negativicutes; Selenomonadales; Acidaminococcaceae;
OC   Acidaminococcus.
OX   NCBI_TaxID=591001;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACIFV_1.PE1759.
CC       Acidaminococcus fermentans DSM 20731, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:HGDA_ACIFV
CC   -!- FUNCTION: Catalyzes the reversible dehydration of 2-
CC       hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the
CC       fermentation of glutamate. It is activated by hgdC.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster.
CC   -!- COFACTOR: FMN.
CC   -!- COFACTOR: Riboflavin.
CC   -!- COFACTOR: Magnesium.
CC   -!- ENZYME REGULATION: Activated by the hgdC protein.
CC   -!- PATHWAY: Amino-acid degradation; L-glutamate degradation via
CC       hydroxyglutarate pathway; crotonoyl-CoA from L-glutamate: step
CC       4/5.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC   -!- GENE_FAMILY: HOG000058646 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P11569; D2RM67; Q44043; -.
DR   EMBL; X14252; CAA32465.1; -; Genomic_DNA.
DR   EMBL; CP001859; ADB48169.1; -; Genomic_DNA.
DR   EMBL; X59645; CAA42197.1; -; Genomic_DNA.
DR   PIR; S04477; DWDXAF.
DR   RefSeq; YP_003399484.1; NC_013740.1.
DR   GeneID; 8738318; -.
DR   GenomeReviews; CP001859_GR; Acfer_1815.
DR   KEGG; afn:Acfer_1815; -.
DR   BioCyc; MetaCyc:MONOMER-1043; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR010327; HGD-D.
DR   Pfam; PF06050; HGD-D; 1.
DR   HOGENOMDNA; ACIFV_1.PE1759; -.
KW   2-hydroxyglutaryl-CoA dehydratase D-component;
KW   4Fe-4S; Complete proteome; Direct protein sequencing; FMN; Iron;
KW   Iron-sulfur; Lyase; Magnesium; Metal-binding.
SQ   SEQUENCE   477 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPKTVSPGVQ ALRDVVEKVY RELREAKERG EKVGWSSSKF PCELAESFGL HVGYPENQAA
     GIAANRDGEV MCQAAEDIGY DNDICGYARI SLAYAAGFRG ANKMDKDGNY VINPHSGKQM
     KDANGKKVFD ADGKPVIDPK TLKPFATTDN IYEIAALPEG EEKTRRQNAL HKYRQMTMPM
     PDFVLCCNNI CNCMTKWYED IARRHNIPLI MIDVPYNEFD HVNEANVKYI RSQLDTAIRQ
     MEEITGKKFD EDKFEQCCQN ANRTAKAWLK VCDYLQYKPA PFNGFDLFNH MADVVTARGR
     VEAAEAFELL AKELEQHVKE GTTTAPFKEQ HRIMFEGIPC WPKLPNLFKP LKANGLNITG
     VVYAPAFGFV YNNLDELVKA YCKAPNSVSI EQGVAWREGL IRDNKVDGVL VHYNRSCKPW
     SGYMPEMQRR FTKDMGIPTA GFDGDQADPR NFNAAQYETR VQGLVEAMEA NDEKKGK
//

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