(data stored in SCRATCH3701 zone)

HOGENOM6: ACTMD_1_PE7

ID   ACTMD_1_PE7                          STANDARD;      PRT;   840 AA.
AC   ACTMD_1_PE7; C6WCG0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (ACTMD_1.PE7).
GN   OrderedLocusNames=Amir_0007;
OS   ACTINOSYNNEMA MIRUM DSM 43827.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Actinosynnemataceae; Actinosynnema.
OX   NCBI_TaxID=446462;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACTMD_1.PE7.
CC       Actinosynnema mirum DSM 43827, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C6WCG0_ACTMD
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6WCG0; -.
DR   EMBL; CP001630; ACU33981.1; -; Genomic_DNA.
DR   RefSeq; YP_003097827.1; NC_013093.1.
DR   STRING; C6WCG0; -.
DR   GeneID; 8324149; -.
DR   GenomeReviews; CP001630_GR; Amir_0007.
DR   KEGG; ami:Amir_0007; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; ACTMD_1.PE7; -.
DR   PRODOM; ACTMD_1_PE7.
DR   SWISS-2DPAGE; ACTMD_1_PE7.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   840 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSETTLPPIG GGSDRTEPRD LQQEMQNSYI DYAMSVIVGR ALPDVRDGLK PVHVRVLYSM
     FDSRFLPERS YNKCARVVGD VMGNYHPHGD SAIYDALVRL AQPWAMRYPL IDGQGNFGSQ
     GNDPAAAMRY TECRLTPLAM RMLADIEEDT VDFRDNYDGR IQEPTVLPSR VPNLLINGSS
     GIAVGMATNI PPHNLREVAE GVVWALDNPE ASDEETLEAM IARIKGPDFP TYGQILGTQG
     IEDAYRTGRG SVKMRAVVEM DEDAKGRTIL VVSELPYQVN PDNLVENIAS LVRDQKINGI
     SNIADESNRR SGMRIVVTVK RDAVAKVVLN NLYKHTQLQY SFGVNMLSLV DGVPRTLRLD
     QMIRHYVKHQ IEVIVRRTKF RLRKAEERAH VWRGLVKALD QLDAVIALIR RSDTTESARS
     GLMELLSVDE VQSNAILEMQ LRRLAALERQ KIIDQLAEIE LQIADLKDIL AKPERQRAIV
     RGELLEIVDK HGDDRRTKIV PFDGDVSMED LIAVEDVVVT ITRTGYAKRT KTDLYRAQKR
     GGKGVQGAQL KQDDIVQHFF VCSTHDWILF FTNKGRVYRT KAYDLPEASR NARGQHVANL
     LAFQPDEEIA QVIQIKNYEA APYLVLATRN GLVKKSKLSD FDSNRSGGLI GINLREEDEL
     VGAVLTGEGD DLLLVSKDGQ SIRFHSSDDV LRPMGRATSG VQGMRFNSDD ELLSMGVVQE
     GLFVLVATDG GYAKRTPIED YPVQGRGGKG VLTIQHDRRR GRLVGALIVD VEDELYAITS
     AGGVIRTSAK EIRKAGRQTK GVRLMNLGEK STLIAVARNA DEPADVSTGE EDDQAIEPAN
//

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