(data stored in ACNUC7421 zone)

HOGENOM: ACTP7_1_PE1011

ID   ACTP7_1_PE1011                       STANDARD;      PRT;   529 AA.
AC   ACTP7_1_PE1011; B3GXU8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bifunctional purine biosynthesis protein purH;
DE   (ACTP7_1.PE1011).
GN   Name=purH; OrderedLocusNames=APP7_1011;
OS   ACTINOBACILLUS PLEUROPNEUMONIAE SEROVAR 7 STR. AP76.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=537457;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACTP7_1.PE1011.
CC       Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:B3GXU8_ACTP7
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
CC   -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl
CC       THF route): step 1/1.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamide: step 1/1.
CC   -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal
CC       region (By similarity).
CC   -!- SIMILARITY: Belongs to the purH family.
CC   -!- GENE_FAMILY: HOG000230372 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B3GXU8; -.
DR   EMBL; CP001091; ACE61663.1; -; Genomic_DNA.
DR   RefSeq; YP_001968805.1; NC_010939.1.
DR   STRING; B3GXU8; -.
DR   GeneID; 6395909; -.
DR   GenomeReviews; CP001091_GR; APP7_1011.
DR   KEGG; apa:APP7_1011; -.
DR   OMA; FTGTRHF; -.
DR   ProtClustDB; PRK00881; -.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:HAMAP.
DR   GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00139; PurH; 1; -.
DR   InterPro; IPR024051; AICAR_Tfase_dom.
DR   InterPro; IPR002695; AICARFT_IMPCHas.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR011607; MGS-like_dom.
DR   Gene3D; G3DSA:3.40.140.20; G3DSA:3.40.140.20; 2.
DR   Gene3D; G3DSA:3.40.50.1380; MGS-like_dom; 1.
DR   PANTHER; PTHR11692; AICARFT_IMPCHas; 1.
DR   Pfam; PF01808; AICARFT_IMPCHas; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR   SMART; SM00798; AICARFT_IMPCHas; 1.
DR   SMART; SM00851; MGS; 1.
DR   SUPFAM; SSF53927; Cytidine_deaminase-like; 1.
DR   SUPFAM; SSF52335; MGS-like_dom; 1.
DR   TIGRFAMs; TIGR00355; PurH; 1.
DR   HOGENOMDNA; ACTP7_1.PE1011; -.
KW   bifunctional purine biosynthesis protein PurH;
KW   Complete proteome; Hydrolase; Multifunctional enzyme;
KW   Purine biosynthesis; Transferase.
SQ   SEQUENCE   529 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAIQQALLSV SDKKGIVEFA QGLVARGVKL LSTGGTAKLL AEAGLPVTEV SDYTGFPEMM
     DGRVKTLHPK VHGGILGRRG MDDEVMNQHD IERIDIVVVN LYPFAATVAN PNCTLEDAVE
     NIDIGGPTMV RSAAKNHKDV AIVVNNNDFD AILAEMDQNQ NELTLETRFN LAIKAFEHTA
     QYDSMIANYF GKLVPPYQGA EEEDLTQVCG QFPRTLNLNF VRKQTMRYGE NSHQNAAFYV
     ENEVKEASVS TAKQLQGKAL SYNNIADTDA ALECVKEFAE PACVIVKHAN PCGVALGKDI
     LEAYNRAYQT DPTSAFGGII AFNRELDGET AQTIAERQFV EVIIAPSVSE AAKAALAKKK
     NVRVLECGEF TQAQKRLDFK RVNGGLLVQD ADQGSVSIDD LQVVSERKPS KEELEDLLFC
     WKVAKYVKSN AIVYAKNGQT IGIGAGQMSR VYSAKIAGIK AEDEGLQVAG CVMASDAFFP
     FRDGIDAAAK VGITCVIHPG GSMRDQEVID AANEHGMAMV LTGMRHFRH
//

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