(data stored in ACNUC5448 zone)

HOGENOM: AEDAE_1068_PE13

ID   AEDAE_1068_PE13                      STANDARD;      PRT;   4155 AA.
AC   AEDAE_1068_PE13; Q176W5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Beta chain spectrin; (AEDAE_1068.PE13).
GN   ORFNames=AAEL006242, AaeL_AAEL006242;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_1068.PE13.
CC       Aedes aegypti supercontig supercont1.196 AaegL1  sequence 1..1880505
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:Q176W5_AEDAE
CC   -!- SIMILARITY: Contains 1 PH domain.
CC   -!- SIMILARITY: Contains 1 SH3 domain.
CC   -!- GENE_FAMILY: HOG000012864 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL006242;AAEL006242-RA;AAEL006242-PA.
DR   EMBL; CH477381; - ;
DR   UniProtKB/Swiss-Prot; Q176W5; -.
DR   EMBL; CH477381; EAT42207.1; -; Genomic_DNA.
DR   RefSeq; XP_001651841.1; XM_001651791.1.
DR   UniGene; Aae.14829; -.
DR   ProteinModelPortal; Q176W5; -.
DR   STRING; Q176W5; -.
DR   EnsemblMetazoa; AAEL006242-RA; AAEL006242-PA; AAEL006242.
DR   GeneID; 5567647; -.
DR   KEGG; aag:AaeL_AAEL006242; -.
DR   VectorBase; AAEL006242; Aedes aegypti.
DR   eggNOG; inNOG07696; -.
DR   GeneTree; EMGT00050000000686; -.
DR   OMA; GLELQKF; -.
DR   OrthoDB; EOG4TDZ10; -.
DR   PhylomeDB; Q176W5; -.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR001605; Spectrin_PH.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Gene3D; G3DSA:1.10.418.10; Calponin-homology; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00435; Spectrin; 30.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00150; SPEC; 30.
DR   SUPFAM; SSF47576; Calponin-homology; 1.
DR   SUPFAM; SSF50044; SH3; 1.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   HOGENOMDNA; AEDAE_1068.PE13; -.
KW   AAEL0062423; AAEL006242-PA ; Q176W5; CH477381;
KW   Actin-binding; Complete proteome; Reference proteome; Repeat;
KW   SH3 domain.
SQ   SEQUENCE   4155 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTQREGIIKF ENERIKTLQE ERLHIQKKTF TKWMNSFLVK AKMEVDDLFT DLADGIKLLK
     LLEIISGEKL GKPNNGRMRV HKIENVNKSL AFLHTKVRLE SIGAEDIVDH NPRLILGLIW
     TIILRFQIQE IEIDVDEENE SSEKKSAKDA LLLWCQRKTQ GYQHVHITDF TNSWRSGLGF
     NALIHSHRPD LFDYNSLMPG RNIENLNHAF EVADRELGIP RLLDAEDIDT ARPDEKSILT
     YVASYYHTFA RMKNEQKGGK RIANIVNKLM DADKKKMQFE NLITDLLSWI RNKTTELEKR
     NFPNSVEGIQ RELLAFKEYR TIEKPPKYKE RSEIEALFFH VNTLLKSLNQ PHYTPQDGKM
     INDIEKAWQR LENAEHNREV ALREELLRQE KLEQLNYKFE KKSVLREGYL NEMIQVLSDP
     RYGANIRQVD ATVKKHEAIS ADILARADRF NDLTDMCNEL HNENYHGKER VKKRETEVIG
     KWKELLELLE NHKVKLTQMS GLMNLLREID ATMSTIQALK VQFASEDVGP HLLGVEELLQ
     AHSLLELQVT TLGETQRRYI RQGEAFKKSG TKDTSQLDQK LAELAKSYEE LQGCSAERRA
     RLDEAHDFYQ FVEDHENEEG WLVDKQRICK AGITAKDLRA VVSLQQKHKA LEDEMKVRKP
     KTLQITEAGK KLITDKHPRK ADVQTKIESL QEHWKALEDL ADVRKRQLDD AAEAYQFYAD
     ANEADSWLNE KMALVASDDF GVDEPSAQAL LQRHRDLQGE LNAYSGDILN LNQQADKLIK
     AGICTLDLSA EPEPAQELEQ EEWVNETRLV PKEVWEEEPV ERLEHKTVTE NKLLPHVRAL
     YPFEGQGMKM AKNEIMILQN KTNPDWWNVR KLDGSEGFVP ANYVKEIEAR PVPCLIRKAE
     KVKVMQKVKK TILVKQVVPV KRVRPAKVSQ VKPLVKRRTE GDTSIDSNDS VDKRQKDINS
     TYDQLQELAE RRRALLEDSI CLFRFYRECD DFEKWIKDKE KMLRTDDPKD NVESAKRKFE
     TFLTDLSASS KRVEAIDSDV EDFVRQGHSQ LDKVKARQRQ IHQMWEHLNY LKGQKEKNLE
     GASSVELFNR TCEEAIDWMN EKMTQLDTAE VGPDLKTVQA LQRRHENLER ELAPVQEKVS
     RVNLLGNTVK NSYPSERDNV TEKQKDIQAL WRKVEEKAKE RRSRLENAVG QQIFTNSSKA
     LLNWIDGVHN QLNAAEPARD VETAENLWKK HNDLGEDIKA HDDEFKQLSQ LGKQLMQRNP
     NLVDVPETLK KLADEQEALY AAWKVKEQKL QQCIELQVFN READKIDATT KSHEAYLEYD
     DLGSSLDDVE AILKRHTDFE NSLGAQDKIL KNFSEGADKL IRNNHYDANY IAERRDQVLL
     RRERVKDLAQ KRRNALQASK DFQKFSADVD DLNVWLADKA KIAGDESYKD LTNLPRKLQK
     HKAFERELRA NEGQLRTVNK EGEALIKTNN RAEEVTSMLA AVNQKWKDLN QSSLEKGRRL
     EQASLQREHN RNIEDAKSKL EELGAALQSK QVGSDLRSCK DLMNKHQILE NDVGMWEQKV
     AELVTSGEEM AHEGHFDANN IKNETKKLQN QFKHLKGPAA KRREALDESL RFHKFVFELD
     AELQWINEHL PAASSEVIGQ NLHQAQSLYK KHKKLEAEIE GHQPMINRTL TSAENLINQD
     HPEKAKVKEL CNTLELAWND LQEKGNERSK KLELSLKAQQ YLSEAGEIET WLGERNNVLR
     STDYGRDRDS ATKLLTKHKG IELELDTYSG IVSEMGHAAS AMVSSKHPDS KVIAAKQQLI
     EKMLKSLQKL AAQRQLRLME SLYRHEYFME SADLEQWIKE QEQAVNSEDY GHDYEHLLIL
     KNKFDDLKHR IEVGAERFNQ CEEFAKKLIG SDSPYVADIE KRQEQLSNCW QNLLKQLAAR
     EKKLHAAGEI HRFHRDAAEA LFRIQDKNAA LSTELGKDLN SALALSRKQE AFENELVALE
     AQLQFLVDDS LRLQAKYPGD NAKAIAAEQE NVIQAWNILK EKSALRNDQL QASCDLQHFL
     TQVRDLMSWA TNLRATLQAE EHVSDATGAT ALKIQHDAIY GEIEAREETF RYLNELSDSM
     VQTGHYAATE VEEKCSALLD ERAKLHSAYN KKKILLEQKI DLFCFMRDAK VIDNLSSGQE
     AALSSSDFGQ TVEVVQDQIK KHDAFEKLIQ TQDEKVAILQ DHGRKLVEQN HYDSENIRRR
     LREIVDRRQK IKELCALRRQ KLQNALLYTQ FIRDCAEAGT WINEKQKKLE ADATSFADVS
     NMEDKVKKLQ KHQAFQAEVA ANEGRIREVK QKGEMLIKKR HECAAEIEDE VRKLSESWNV
     LLNEVASRGR GLEEAQDILE FDSQLDKLEA WIRDKEMMVH ASDTGRDLEH CNALKRKLDD
     VDSDMRVDDQ RIKTINVLAD KLLTQDKVPN EAKNVQQRRN NFNNKWKSLQ GALNKYRELL
     DGAYEIHVFN RDVDDTAERI SEKQVAMSVD DTGRDLNAVE ALKRKQDAMK RDMTAVQQKI
     QEHEKRAKLL AQKYPDNAVN IEEKLAELKR QWNNLQEASV KRAEALENGY TAHKFTADVK
     ELELWTNDIM KKMDSSSNPT TIAECQAQIQ LHRERKAEID GRDKIFKALQ EHGERLVANN
     KAMGVKNDYV EKALRQLEDL NKHLHDSWKG KDRFLKEAYQ LQQFKEQADQ IEAWLANKEA
     FLNNDDLGDT FTAVEALIKK HEAFEKLLAA SRTDELEKFA EEILAESPFE ADVIKQRLCS
     VIARKNKLLA SSAARKQKLQ ESLQLQQFLR GLYEVAKWIA QKMQVALDEN YREPSNLQSK
     IQKHVAFDAE LGANSTRVTA IIDEGETLIN AEHYASELVK EQLDILEADW QKLREASREK
     KECLAEAYEA RLFERNLDDF NNWMDEVEGQ LSSEDYGKDL ASVNNLLKKH EMLEADVAHH
     LETCEQIKAA DDKFLVSDHF MKDELHESAM MTIKRYHSLH EPTTIRRDNL EDSLQLHQFL
     RDAEDELLWL NEKEPLAASK DLGSSLTAVQ SLQKKHQALE AEILSQEPTI SALIQRGQQM
     IRENHYAVEQ IESQSNLLQQ KLVNLRDLTN VRRLRLLDAV ESQQFYAEAN EAESWLKEKK
     PIISSHDYGK DEDSVGSLQK KLDALQRELV AFKPTVEKID KLAVGLQERG HFDSEKIKTK
     NDKIQYQFHE LNRLAGEREK KLAETKKLFE FIREIDDLQE WIEMQMTTAG SEEYGTDVEH
     VEQLTAQFES FVSNMNSNEA RVNACVAKGE SLLNEGNPNK DIIKGKRDET KQLWEELKDL
     VVARQEALAG AKQVHVFDRT ADETIGWINE KISAVLSEDY SHDLETIQAL VRTHEGFEAE
     LGAIKEQLES VVAEAQKLGD TFPDAKEHIE VKRDETIEAW SELKEKTIQR KEKLMQAEQL
     QAYFDEYRDL MAWINEMLAQ ITAPELAKDV AGAEALIVKI KEHKTEVDSR SEAFETFYKT
     GNKLIKDGHL LANEVQVKIG VLEQRKRLLD NTISQRAEIY ELNLDTQLFL KEAEVIESWI
     ITRQVQLKDG KLGDSIAQVE DLIRKHEDFE KTVAAQEEKV LALKRITLLE QKFKKQLEAE
     HAARIAEKER IERERHEALK QKEVQRITEE RRRHDANSSA VNGYDTPIKS STPSHLSPAS
     AAGLSKEAPD MSPVQKSNSF ATMLQERLRR GSEGNIKRAE SMKIGPKPAK RTPSFTTRRR
     AQSFRKNQRG LEPAESDLPP VEMQGMLERK HESQSGGKKA PVRSWKPFYT VLCGQLLCFF
     KDVEDFAQKK AATAPVNILS AKCERAEDYT KKKNVFRLVL QDASEFLFLT GSKESMNEWV
     NKIAFHAALP PNLQLMSYDE SMKINPQSPI LDRSDANSSI SSRTSSPDSQ RRDSRASLNS
     AKSGGSGSNA SSSLQTPQIA FLQKQKELRE QENQQRLSQQ QQQQQQNIST FQTPQSPTQE
     FYGLADKPPI PPRGVPPPVP QRQSSTENVL NNNVSSNSTV QIRPKTSSGS SGSYNGNDYD
     NGNYTNAPRP FSHQPNTATQ RGVPVNGSNN NNGNGEDVWL RHSELRSSGW GQSRHEANRP
     ASLPVGGVPP TTVSSPGDMS GLVLGRHQQQ SAESSSESEA SFIKGGGSTK EAKDKKAGSS
     GVFRIFSKKK SKNHN
//

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