(data stored in ACNUC30567 zone)

HOGENOM: AEDAE_1125_PE9

ID   AEDAE_1125_PE9                       STANDARD;      PRT;   562 AA.
AC   AEDAE_1125_PE9; P50635; Q176L2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Apyrase; EC=3.6.1 5;AltName: Full=ATP-diphosphatase;
DE   Short=ADPase;AltName: Full=ATP-diphosphohydrolase;AltName: Full=Adenosine
DE   diphosphatase;AltName: Allergen=Aed a 1;Flags: Precursor;
DE   (AEDAE_1125.PE9).
GN   Name=APY; ORFNames=AAEL006347;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_1125.PE9.
CC       Aedes aegypti supercontig supercont1.201 AaegL1  sequence 1..1818773
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:APY_AEDAE
CC   -!- FUNCTION: Facilitates hematophagy by preventing ADP-dependent
CC       platelet aggregation in the host. May reduce probing time by
CC       facilitating the speed of locating blood.
CC   -!- CATALYTIC ACTIVITY: ATP + 2 H(2)O = AMP + 2 phosphate.
CC   -!- COFACTOR: Divalent cations (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Salivary gland specific.
CC   -!- DEVELOPMENTAL STAGE: Not detectable in females on the first day
CC       after eclosion, but is detectable on the second day. It is
CC       maximally expressed by day 4.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC   -!- GENE_FAMILY: HOG000247215 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL006347;AAEL006347-RA;AAEL006347-PA.
DR   EMBL; CH477386; - ;
DR   EMBL; L12389; - ;
DR   EMBL; L41391; - ;
DR   UniProtKB/Swiss-Prot; P50635; Q176L2; -.
DR   EMBL; L12389; AAC37218.1; -; mRNA.
DR   EMBL; L41391; AAA99189.1; -; Genomic_DNA.
DR   EMBL; CH477386; EAT42070.1; -; Genomic_DNA.
DR   RefSeq; XP_001651910.1; XM_001651860.1.
DR   UniGene; Aae.5859; -.
DR   ProteinModelPortal; P50635; -.
DR   Allergome; 3; Aed a 1.
DR   Allergome; 3539; Aed a 1.0101.
DR   EnsemblMetazoa; AAEL006347-RA; AAEL006347-PA; AAEL006347.
DR   GeneID; 5567877; -.
DR   KEGG; aag:AaeL_AAEL006347; -.
DR   eggNOG; KOG4419; -.
DR   GeneTree; EMGT00050000013508; -.
DR   InParanoid; P50635; -.
DR   OMA; LADGKDG; -.
DR   OrthoDB; EOG4VX0MQ; -.
DR   PhylomeDB; P50635; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR006146; 5'-Nucleotdase_CS.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Metallo_PEstase_dom.
DR   Gene3D; G3DSA:3.90.780.10; 5'-Nucleotdase_C; 1.
DR   PANTHER; PTHR11575; 5_nucleotidase; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF55816; 5'-Nucleotdase_C; 1.
DR   PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
DR   PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
DR   HOGENOMDNA; AEDAE_1125.PE9; -.
KW   AAEL0063473; AAEL006347-PA ; P50635; CH477386; L12389; L41391;
KW   Allergen; ATP-binding; Direct protein sequencing; Glycoprotein;
KW   Hydrolase; Metal-binding; Nucleotide-binding; Secreted; Signal.
SQ   SEQUENCE   562 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGRPGYSEV IFLYVVSVAV IARATDNMPV NKDVSKLFPL TLIHINDLHA RFEETNMKSN
     VCTQKDQCIA GIARVYQKIK DLLKEYESKN PIYLNAGDNF QGTLWYNLLR WNVTADFIKK
     LKPAAMTLGN HEFDHTPKGL APYLAELNKE GIPTIVANLV MNNDPDLKSS KIPKSIKLTV
     GKRKIGIIGV LYDKTHEIAQ TGKVTLSNAV EAVRREAAAL KKDNIDIIVV LSHCSYEEDK
     KIAAEAGDDI DVIVGAHSHS FLYSPDSKQP HDPKDKVEGP YPTLVESKNK RKIPIVQAKS
     FGKYVGRLTL YFDEEGEVKN WEGYPVFIDH KVQQDPQILK DLVPWRAKVE AIGSTVVGET
     MIELDRDSCR DQECTLGVLY ADGFADQYTN DTFRPFAIIQ AGNFRNPIKV GKITNGDIIE
     AAPFGSTADL IRLKGADIWD VAEHSFALDD EGRTNCLQVS GLRIVIDISK PVRSRVKKIE
     VMDYTNPKSD KLKPLDKEAE YYIVVPSYLA DGKDGFSAMK RATARRTGPL DSDVFKNYVE
     KIKKVDNLKL GRVIVCKGSK CT
//

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