(data stored in ACNUC30567 zone)

HOGENOM: AEDAE_2046_PE12

ID   AEDAE_2046_PE12                      STANDARD;      PRT;   254 AA.
AC   AEDAE_2046_PE12; P29786; Q170R6; Q8MMK9; Q8T637;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Trypsin 3A1; EC=3.4.21 4;Flags: Precursor;
DE   (AEDAE_2046.PE12).
GN   ORFNames=AAEL007818;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_2046.PE12.
CC       Aedes aegypti supercontig supercont1.284 AaegL1  sequence 1..1500899
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:TRY3_AEDAE
CC   -!- FUNCTION: Major function may be to aid in digestion of the blood
CC       meal.
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B;
CC         IsoId=P29786-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=P29786-2; Sequence=VSP_035031;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Midgut.
CC   -!- INDUCTION: By blood feed.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
CC   -!- GENE_FAMILY: HOG000251820 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL007818;AAEL007818-RB;AAEL007818-PB.
DR   EMBL; AF487426; - ;
DR   EMBL; AF508783; - ;
DR   EMBL; CH477469; - ;
DR   EMBL; X64362; - ;
DR   UniProtKB/Swiss-Prot; P29786; Q170R6; Q8MMK9; Q8T637; -.
DR   EMBL; AF487426; AAL93209.1; -; mRNA.
DR   EMBL; AF508783; AAM34268.1; -; Transcribed_RNA.
DR   EMBL; X64362; CAA45714.1; -; mRNA.
DR   EMBL; CH477469; EAT40452.1; -; Genomic_DNA.
DR   EMBL; CH477469; EAT40453.1; -; Genomic_DNA.
DR   PIR; S19890; TRWV3Y.
DR   RefSeq; XP_001652943.1; XM_001652893.1.
DR   RefSeq; XP_001652944.1; XM_001652894.1.
DR   UniGene; Aae.20570; -.
DR   ProteinModelPortal; P29786; -.
DR   MEROPS; S01.130; -.
DR   EnsemblMetazoa; AAEL007818-RB; AAEL007818-PB; AAEL007818.
DR   GeneID; 5569681; -.
DR   KEGG; aag:AaeL_AAEL007818; -.
DR   eggNOG; meNOG22662; -.
DR   GeneTree; EMGT00050000002494; -.
DR   InParanoid; P29786; -.
DR   OrthoDB; EOG4C2FSW; -.
DR   PhylomeDB; P29786; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR009003; Pept_cys/ser_Trypsin-like.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Pept_Ser_Cys; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
DR   HOGENOMDNA; AEDAE_2046.PE12; -.
KW   AAEL0078183; AAEL007818-PB ; P29786; AF487426; AF508783; CH477469;
KW   X64362;
KW   Alternative splicing; Digestion; Disulfide bond; Hydrolase; Protease;
KW   Secreted; Serine protease; Signal; Zymogen.
SQ   SEQUENCE   254 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNQFLFVSFC ALLGLSQVSA ATLSSGRIVG GFQIDIAEVP HQVSLQRSGR HFCGGSIISP
     RWVLTAAHCT TNTDPAAYTI RAGSTDRTNG GIIVKVKSVI PHPQYNGDTY NYDFSLLELD
     ESIGFSRSIE AIALPEASET VADGAMCTVS GWGDTKNVFE MNTLLRAVNV PSYNQAECAA
     ALVNVVPVTE QMICAGYAAG GKDSCQGDSG GPLVSGDKLV GVVSWGKGCA LPNLPGVYAR
     VSTVRQWIRE VSEV
//

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