(data stored in ACNUC30567 zone)

HOGENOM: AEDAE_3458_PE4

ID   AEDAE_3458_PE4                       STANDARD;      PRT;   522 AA.
AC   AEDAE_3458_PE4; P49880; Q16VE1; Q6VA69;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Ecdysone receptor;AltName: Full=20-hydroxy-ecdysone
DE   receptor; Short=20E receptor;AltName: Full=EcRH; Short=AaEcR;AltName:
DE   Full=Ecdysteroid receptor;AltName: Full=Nuclear receptor subfamily 1
DE   group H member 1; (AEDAE_3458.PE4).
GN   Name=EcR; Synonyms=NR1H1; ORFNames=AAEL009600;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_3458.PE4.
CC       Aedes aegypti supercontig supercont1.411 AaegL1  sequence 1..1059710
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:ECR_AEDAE
CC   -!- FUNCTION: Receptor for ecdysone. Binds to ecdysone response
CC       elements (ECRES).
CC   -!- SUBUNIT: Heterodimer of USP and ECR. Only the heterodimer is
CC       capable of high-affinity binding to ecdysone.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=P49880-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P49880-2; Sequence=VSP_035029;
CC   -!- TISSUE SPECIFICITY: A peak level expression is seen in the fat
CC       body of previtellogenic female mosquitos at one and two days after
CC       eclosion, levels fall three-fold at three days posteclosion.
CC   -!- INDUCTION: Transcripts exhibit dramatically different patterns of
CC       expression after blood meal-triggered activation of vitellogenesis
CC       in the fat body. Isoform B is highly expressed and reaches its
CC       peak at 4 hours pbm (post blood meal). Isoform A peaks at 16-20
CC       hours, when isoform B expression is lowest.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT38529.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000220845 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL009600;AAEL009600-RA;AAEL009600-PA.
DR   EMBL; AY345989; - ;
DR   EMBL; CH477596; - ;
DR   EMBL; CH477685; - ;
DR   EMBL; U02021; - ;
DR   UniProtKB/Swiss-Prot; P49880; Q16VE1; Q6VA69; -.
DR   EMBL; U02021; AAA87394.1; -; mRNA.
DR   EMBL; AY345989; AAQ23183.1; -; mRNA.
DR   EMBL; CH477596; EAT38529.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH477685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001660279.1; XM_001660229.1.
DR   UniGene; Aae.8787; -.
DR   ProteinModelPortal; P49880; -.
DR   SMR; P49880; 285-371, 431-671.
DR   STRING; P49880; -.
DR   EnsemblMetazoa; AAEL009600-RA; AAEL009600-PA; AAEL009600.
DR   EnsemblMetazoa; AAEL009600-RB; AAEL009600-PB; AAEL009600.
DR   GeneID; 5572184; -.
DR   KEGG; aag:AaeL_AAEL009600; -.
DR   eggNOG; inNOG06886; -.
DR   GeneTree; EMGT00070000025663; -.
DR   InParanoid; P49880; -.
DR   OrthoDB; EOG431ZD7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004884; F:ecdysteroid hormone receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003069; Ecdystd_rcpt.
DR   InterPro; IPR008946; Nucl_hormone_rcpt_ligand-bd.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
DR   InterPro; IPR001723; Str_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Gene3D; G3DSA:1.10.565.10; Nucl_hrmn_rcpt_lig_bd; 2.
DR   Gene3D; G3DSA:3.30.50.10; Znf_NHR/GATA; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01283; ECDYSTEROIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; Str_ncl_receptor; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOGENOMDNA; AEDAE_3458.PE4; -.
KW   AAEL0096003; AAEL009600-PA ; P49880; AY345989; CH477596; CH477685;
KW   U02021;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   522 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     TGREDLSPSS SLNGYTDGSD AKKQKKGPTP RQQEELCLVC GDRASGYHYN ALTCEGCKGF
     FRRSVTKNAV YCCKFGHACE MDMYMRRKCQ ECRLKKCLAV GMRPECVVPE NQCAIKRKEK
     KAQKEKDKVQ TNATVSTTNS TYRSEILPIL MKCDPPPHQA IPLLPEKLLQ ENRLRNIPLL
     TANQMAVIYK LIWYQDGYEQ PSEEDLKRIM IGSPNEEEDQ HDVHFRHITE ITILTVQLIV
     EFAKGLPAFT KIPQEDQITL LKACSSEVMM LRMARRYDAA TDSILFANNR SYTRDSYRMA
     GMADTIEDLL HFCRQMFSLT VDNVEYALLT AIVIFSDRPG LEQAELVEHI QSYYIDTLRI
     YILNRHAGDP KCSVIFAKLL SILTELRTLG NQNSEMCFSL KLKNRKLPRF LEEIWDVQDI
     PPSMQAQMHS HGTQSSSSSS SSSSSSSNGS SNGNSSSNSN SSQHGPHPHP HGQQLTPNQQ
     QHQQQHSQLQ QVHANGSGSG GGSNNNSSSG GVVPGLGMLD QV
//

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