HOGENOM: AEDAE_3458_PE5

ID   AEDAE_3458_PE5                       STANDARD;      PRT;   521 AA.
AC   AEDAE_3458_PE5; P49880; Q16VE1; Q6VA69;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Ecdysone receptor;AltName: Full=20-hydroxy-ecdysone
DE   receptor; Short=20E receptor;AltName: Full=EcRH; Short=AaEcR;AltName:
DE   Full=Ecdysteroid receptor;AltName: Full=Nuclear receptor subfamily 1
DE   group H member 1; (AEDAE_3458.PE5).
GN   Name=EcR; Synonyms=NR1H1; ORFNames=AAEL009600;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_3458.PE5.
CC       Aedes aegypti supercontig supercont1.411 AaegL1  sequence 1..1059710
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:ECR_AEDAE
CC   -!- FUNCTION: Receptor for ecdysone. Binds to ecdysone response
CC       elements (ECRES).
CC   -!- SUBUNIT: Heterodimer of USP and ECR. Only the heterodimer is
CC       capable of high-affinity binding to ecdysone.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=P49880-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P49880-2; Sequence=VSP_035029;
CC   -!- TISSUE SPECIFICITY: A peak level expression is seen in the fat
CC       body of previtellogenic female mosquitos at one and two days after
CC       eclosion, levels fall three-fold at three days posteclosion.
CC   -!- INDUCTION: Transcripts exhibit dramatically different patterns of
CC       expression after blood meal-triggered activation of vitellogenesis
CC       in the fat body. Isoform B is highly expressed and reaches its
CC       peak at 4 hours pbm (post blood meal). Isoform A peaks at 16-20
CC       hours, when isoform B expression is lowest.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT38529.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000220845 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL009600;AAEL009600-RB;AAEL009600-PB.
DR   EMBL; AY345989; - ;
DR   EMBL; CH477596; - ;
DR   EMBL; CH477685; - ;
DR   EMBL; U02021; - ;
DR   UniProtKB/Swiss-Prot; P49880; Q16VE1; Q6VA69; -.
DR   EMBL; U02021; AAA87394.1; -; mRNA.
DR   EMBL; AY345989; AAQ23183.1; -; mRNA.
DR   EMBL; CH477596; EAT38529.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH477685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001660279.1; XM_001660229.1.
DR   UniGene; Aae.8787; -.
DR   ProteinModelPortal; P49880; -.
DR   SMR; P49880; 285-371, 431-671.
DR   STRING; P49880; -.
DR   EnsemblMetazoa; AAEL009600-RA; AAEL009600-PA; AAEL009600.
DR   EnsemblMetazoa; AAEL009600-RB; AAEL009600-PB; AAEL009600.
DR   GeneID; 5572184; -.
DR   KEGG; aag:AaeL_AAEL009600; -.
DR   eggNOG; inNOG06886; -.
DR   GeneTree; EMGT00070000025663; -.
DR   InParanoid; P49880; -.
DR   OrthoDB; EOG431ZD7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004884; F:ecdysteroid hormone receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003069; Ecdystd_rcpt.
DR   InterPro; IPR008946; Nucl_hormone_rcpt_ligand-bd.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
DR   InterPro; IPR001723; Str_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Gene3D; G3DSA:1.10.565.10; Nucl_hrmn_rcpt_lig_bd; 2.
DR   Gene3D; G3DSA:3.30.50.10; Znf_NHR/GATA; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01283; ECDYSTEROIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; Str_ncl_receptor; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   HOGENOMDNA; AEDAE_3458.PE5; -.
KW   AAEL0096003; AAEL009600-PB ; P49880; AY345989; CH477596; CH477685;
KW   U02021;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   521 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     GREDLSPSSS LNGYTDGSDA KKQKKGPTPR QQEELCLVCG DRASGYHYNA LTCEGCKGFF
     RRSVTKNAVY CCKFGHACEM DMYMRRKCQE CRLKKCLAVG MRPECVVPEN QCAIKRKEKK
     AQKEKDKVQT NATVSTTNST YRSEILPILM KCDPPPHQAI PLLPEKLLQE NRLRNIPLLT
     ANQMAVIYKL IWYQDGYEQP SEEDLKRIMI GSPNEEEDQH DVHFRHITEI TILTVQLIVE
     FAKGLPAFTK IPQEDQITLL KACSSEVMML RMARRYDAAT DSILFANNRS YTRDSYRMAG
     MADTIEDLLH FCRQMFSLTV DNVEYALLTA IVIFSDRPGL EQAELVEHIQ SYYIDTLRIY
     ILNRHAGDPK CSVIFAKLLS ILTELRTLGN QNSEMCFSLK LKNRKLPRFL EEIWDVQDIP
     PSMQAQMHSH GTQSSSSSSS SSSSSSNGSS NGNSSSNSNS SQHGPHPHPH GQQLTPNQQQ
     HQQQHSQLQQ VHANGSGSGG GSNNNSSSGG VVPGLGMLDQ V
//