(data stored in ACNUC30567 zone)

HOGENOM: AEDAE_4582_PE45

ID   AEDAE_4582_PE45                      STANDARD;      PRT;   679 AA.
AC   AEDAE_4582_PE45; Q17FM7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=NADPH--cytochrome P450 reductase; EC=1.6.2 4;
DE   (AEDAE_4582.PE45).
GN   ORFNames=AAEL003349, AaeL_AAEL003349;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_4582.PE45.
CC       Aedes aegypti supercontig supercont1.84 AaegL1  sequence 1..2919364
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:Q17FM7_AEDAE
CC   -!- FUNCTION: This enzyme is required for electron transfer from NADP
CC       to cytochrome P450 (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADPH + n oxidized hemoprotein = NADP(+) + n
CC       reduced hemoprotein.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane (By
CC       similarity).
CC   -!- SIMILARITY: In the C-terminal section; belongs to the flavoprotein
CC       pyridine nucleotide cytochrome reductase family.
CC   -!- GENE_FAMILY: HOG000282027 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL003349;AAEL003349-RA;AAEL003349-PA.
DR   EMBL; CH477269; - ;
DR   UniProtKB/Swiss-Prot; Q17FM7; -.
DR   EMBL; CH477269; EAT45397.1; -; Genomic_DNA.
DR   RefSeq; XP_001656715.1; XM_001656665.1.
DR   UniGene; Aae.13314; -.
DR   ProteinModelPortal; Q17FM7; -.
DR   SMR; Q17FM7; 70-235.
DR   EnsemblMetazoa; AAEL003349-RA; AAEL003349-PA; AAEL003349.
DR   GeneID; 5577930; -.
DR   KEGG; aag:AaeL_AAEL003349; -.
DR   VectorBase; AAEL003349; Aedes aegypti.
DR   eggNOG; inNOG04903; -.
DR   GeneTree; EMGT00050000002229; -.
DR   OMA; XINISRT; -.
DR   OrthoDB; EOG4CC2G8; -.
DR   PhylomeDB; Q17FM7; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:EC.
DR   InterPro; IPR003097; FAD-binding_1.
DR   InterPro; IPR017927; Fd_Rdtase_FAD-bd.
DR   InterPro; IPR001094; Flavdoxin.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR023208; P450R.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   Gene3D; G3DSA:1.20.990.10; NADPH_Cyt_P450_Rdtase_dom3; 1.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PIRSF; PIRSF000208; P450R; 1.
DR   PRINTS; PR00369; FLAVODOXIN.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF63380; Riboflavin_synthase_like_b-brl; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR   HOGENOMDNA; AEDAE_4582.PE45; -.
KW   AAEL0033493; AAEL003349-PA ; Q17FM7; CH477269;
KW   Complete proteome; Endoplasmic reticulum; Membrane; NADP;
KW   Oxidoreductase; Reference proteome.
SQ   SEQUENCE   679 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDAQTEPEVP PAPISDEPFL GPLDIILLAV LIGGAAWYFL KSKKKDTQTS QFKSYSIQPT
     TVNTMTMAEN SFIKKLKSSG RRLVVFYGSQ TGTAEEFAGR LAKEGLRYQM KGMVADPEEC
     DMEELLSLKD IDKSLAVFCL ATYGEGDPTD NCMEFYDWIQ NNDVDFSGLN YAVFGLGNKT
     YEHYNKVGIY VDKRLEELGA NRVFELGLGD DDANIEDDFI TWKDKFWPAV CDHFGIESSG
     EEVLMRQYRL LEQPETPTER LYTGEVARLH SLQTQRPPFD AKNPFLAPIK VNRELHKAGG
     RSCMHIEFDI EGSKMRYEAG DHLAMYPVND QDLVLRLGKL CNADLDTIFS LINTDTDSSK
     KHPFPCPTTY RTALTHYLEI TALPRTHILK ELAEYCSEEK DKEFLRFMCS TNPEGKAKYQ
     EWVQDSCRNI VHVLEDLPSC RPPIDHICEL LPRLQPRYYS ISSSSKLYPT TVHVTAVLVK
     YETKTGRVNH GVATTFLSQK HPLDGEPLPR VPIFIRKSQF RLPAKTETPV IMVGPGTGLA
     PFRGFIQERD FNKKDGKEVG QTILYFGCRK RSEDYIYEEE LEDYVQRGIM KLRTAFSRDQ
     AHKVYVTHLL EEDMDLLWNV IGENKGHFYI CGDAKNMATD VRNILLKVLQ TKGSMSESEA
     IQYIKKMEAQ KRYSADVWS
//

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