(data stored in ACNUC7421 zone)

HOGENOM: AEDAE_4685_PE4

ID   AEDAE_4685_PE4                       STANDARD;      PRT;   360 AA.
AC   AEDAE_4685_PE4; Q16I17;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (AEDAE_4685.PE4).
GN   ORFNames=AAEL013828;
OS   AEDES AEGYPTI.
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae;
OC   Culicini; Aedes.
OX   NCBI_TaxID=7159;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEDAE_4685.PE4.
CC       Aedes aegypti supercontig supercont1.932 AaegL1 full sequence 1..371432
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:MTNA_AEDAE
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Aedes_aegypti;AAEL013828;AAEL013828-RA;AAEL013828-PA.
DR   EMBL; CH478117; - ;
DR   UniProtKB/Swiss-Prot; Q16I17; -.
DR   EMBL; CH478117; EAT33907.1; -; Genomic_DNA.
DR   RefSeq; XP_001664017.1; XM_001663967.1.
DR   UniGene; Aae.9957; -.
DR   ProteinModelPortal; Q16I17; -.
DR   STRING; Q16I17; -.
DR   EnsemblMetazoa; AAEL013828-RA; AAEL013828-PA; AAEL013828.
DR   GeneID; 5578712; -.
DR   KEGG; aag:AaeL_AAEL013828; -.
DR   VectorBase; AAEL013828; Aedes aegypti.
DR   eggNOG; inNOG04539; -.
DR   GeneTree; EMGT00050000012154; -.
DR   OMA; RPRNQGA; -.
DR   OrthoDB; EOG40P2P9; -.
DR   PhylomeDB; Q16I17; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; AEDAE_4685.PE4; -.
KW   AAEL0138283; AAEL013828-PA ; Q16I17; CH478117;
KW   Amino-acid biosynthesis; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus.
SQ   SEQUENCE   360 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSLKAIKYSN GKLEILDQLL LPAQSKYIDV KGVEDGWKAI NKMQVRGAPA IAIVGCLSLA
     VEIFGEKFDT KQTFKQEVEG KLNYLVSARP TAVNMKLAAE DLISLANALA QDESISVDTM
     KERFLKAIED MLDKDIADNM AIGKNGADII LSHIPNGGSV RILTHCNTGS LATAGYGTAL
     GVIRKLHEMN RLEHVYCTET RPYNQGARLT AYELVHDKLP ATLILDNMVA SLFKSRRVAA
     VVVGADRVAA NGDTANKIGT YQIGVVAKYH DVPFYVAAPF TSIDLKIPSG DRIVIEERPD
     REMTHVGEHR IAAPGIACWN PAFDVTTADL ITGIITEKGV FKPAELKEKV EQIISTNQKL
//

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