(data stored in ACNUC7421 zone)

HOGENOM: AEPER1_1_PE10

ID   AEPER1_1_PE10                        STANDARD;      PRT;   553 AA.
AC   AEPER1_1_PE10; Q9YG88;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dihydroxy-acid dehydratase; Short=DAD; EC=4.2.1 9;
DE   (AEPER1_1.PE10).
GN   Name=ilvD; OrderedLocusNames=APE_0013.1;
OS   AEROPYRUM PERNIX K1.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEPER1_1.PE10.
CC       Aeropyrum pernix K1, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:ILVD_AERPE
CC   -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC       oxobutanoate + H(2)O.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 3/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 3/4.
CC   -!- SIMILARITY: Belongs to the ilvD/edd family.
CC   -!- GENE_FAMILY: HOG000173155 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9YG88; -.
DR   EMBL; BA000002; BAA78922.2; -; Genomic_DNA.
DR   PIR; H72752; H72752.
DR   RefSeq; NP_146903.2; NC_000854.2.
DR   ProteinModelPortal; Q9YG88; -.
DR   GeneID; 1445585; -.
DR   GenomeReviews; BA000002_GR; APE_0013.1.
DR   KEGG; ape:APE_0013.1; -.
DR   NMPDR; fig|272557.1.peg.10; -.
DR   ProtClustDB; PRK00911; -.
DR   BioCyc; APER272557:APE0013-MON; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009082; P:branched chain family amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00012; IlvD; 1; -.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR004404; DihydroxyA_deHydtase.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   PANTHER; PTHR21000; ILVD_EDD_family; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF52016; Aconitase/3IPM_dehydase_swvl; 1.
DR   TIGRFAMs; TIGR00110; IlvD; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
DR   HOGENOMDNA; AEPER1_1.PE10; -.
KW   4Fe-4S; Amino-acid biosynthesis;
KW   Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW   Iron-sulfur; Lyase; Metal-binding.
SQ   SEQUENCE   553 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKRPRSRLWY DGLENTPHRV YLRAIGFTSD DFQKPLIAVV AAWSEAGPCN FNVLPGSLRV
     KEGVRSAGGV PLAVPTIVVN DGINMGTPGM RYSLISRELI ADTIEAQVAS HGFDGWVGIG
     GCDKTQPGIM MAMARLDLPS IYIYGGTAEH GVLDGETVTV QSAFEAVGAY LKGLIDEERL
     YEIEKAAMPT PGTCQGLFTA NTMAILAEAL GLSPLGSASP PATSSERARE LARAGALAVG
     LVETGLTPRR ILTYEAFYNA IVTLMAISGS TNAVLHLLAI AREAGVKLAL DDFDEASRKV
     PVIAALAPAG KYTMVDLHNV GGAPVILRKL LDRGLLYGEA VTVEGVEIGK LLSKWEPRTD
     YNILYDFDKP YKPHAGLRIL RGSLAPRGAV MKIGASGILK FKGAAKVFDS EEEAFKAIER
     GYVEEGDVVV VRYVGPKGAP GMPEMLKITA AIVGAGLGEK VALITDGRFS GATRGVMVGH
     AAPEAAVGGP IALVENGDEI VIDGEKGTLD VLLGGDELAR RRDKWSPPPL PKQGLLRKYA
     KLVTQADEGA VTH
//

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