(data stored in ACNUC30630 zone)

HOGENOM: AEPER1_1_PE1658

ID   AEPER1_1_PE1658                      STANDARD;      PRT;   438 AA.
AC   AEPER1_1_PE1658; Q9Y8T0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (AEPER1_1.PE1658).
GN   Name=trpE; OrderedLocusNames=APE_2553.1;
OS   AEROPYRUM PERNIX K1.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AEPER1_1.PE1658.
CC       Aeropyrum pernix K1, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:TRPE_AERPE
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9Y8T0; -.
DR   EMBL; BA000002; BAA81570.2; -; Genomic_DNA.
DR   PIR; B72489; B72489.
DR   RefSeq; NP_148690.2; NC_000854.2.
DR   ProteinModelPortal; Q9Y8T0; -.
DR   GeneID; 1445497; -.
DR   GenomeReviews; BA000002_GR; APE_2553.1.
DR   KEGG; ape:APE_2553.1; -.
DR   OMA; FAVEKYS; -.
DR   BioCyc; APER272557:APE2553-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   HOGENOMDNA; AEPER1_1.PE1658; -.
KW   anthranilate synthase component I;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Tryptophan biosynthesis.
SQ   SEQUENCE   438 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPSPPEPPLH WRDCRLEPIL GFPRPRELAK SLEVQGEEWI ALLESGGGLQ HRSRYSFLAW
     GRRKSSETDA IRAYEELERL ADDKCRALPC RSPTFFLVSY EAVVGEEPWL SRLVGRHEWP
     GMTAFSPEYV VVYDHAGGRV SVCPGDTPLP APASRKESFS AEGPTYETSR KGFEAMVADA
     LERIRAGEAF QVVLSRVERY RVWGSLFSAY ERLADANPSP YLYYARLGGR VIIGSSPELL
     VKLEAGRVET HPIAGTRPRG STPIEDIELE VELLNDEKER AEHVMLVDLA RNDITRVSIP
     GTVQVTSFMD IERYETVMHI VSRVEGVTRP STTFVEALKA LHPAGTVSGA PKPRAMEIIA
     ELEEEARGPY AGAIGVAGSS AGEAAIVLRS AWLLDDGETL EARAGAGIVY DSKPEREYME
     TVQKLGSLKR ALGVDMCG
//

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