(data stored in ACNUC7421 zone)

HOGENOM: AERHH_1_PE1001

ID   AERHH_1_PE1001                       STANDARD;      PRT;   362 AA.
AC   AERHH_1_PE1001; A0KH32;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3 1; EC=2.3.1
DE   180;AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III
DE   1;AltName: Full=Beta-ketoacyl-ACP synthase III 1; (AERHH_1.PE1001).
GN   Name=fabH1; OrderedLocusNames=AHA_1040;
OS   AEROMONAS HYDROPHILA SUBSP. HYDROPHILA ATCC 7966.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AERHH_1.PE1001.
CC       Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:A0KH32_AERHH
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP. Catalyzes the first condensation reaction which
CC       initiates fatty acid synthesis and may therefore play a role in
CC       governing the total rate of fatty acid production. Possesses both
CC       acetoacetyl-ACP synthase and acetyl transacylase activities. Its
CC       substrate specificity determines the biosynthesis of branched-
CC       chain and/or straight-chain of fatty acids (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + malonyl-[acyl-carrier-protein] =
CC       acetoacetyl-[acyl-carrier-protein] + CoA + CO(2).
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- DOMAIN: The last Arg residue of the ACP-binding site is essential
CC       for the weak association between ACP/AcpP and FabH (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the fabH family.
CC   -!- GENE_FAMILY: HOG000246674 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A0KH32; -.
DR   EMBL; CP000462; ABK35868.1; -; Genomic_DNA.
DR   RefSeq; YP_855582.1; NC_008570.1.
DR   ProteinModelPortal; A0KH32; -.
DR   STRING; A0KH32; -.
DR   GeneID; 4489488; -.
DR   GenomeReviews; CP000462_GR; AHA_1040.
DR   KEGG; aha:AHA_1040; -.
DR   TIGR; AHA_1040; -.
DR   eggNOG; COG0332; -.
DR   OMA; IKLCNER; -.
DR   PhylomeDB; A0KH32; -.
DR   ProtClustDB; PRK12879; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:HAMAP.
DR   GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01815; FabH; 1; -.
DR   InterPro; IPR013751; ACP_syn_III.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004655; FabH_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   Pfam; PF08545; ACP_syn_III; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   TIGRFAMs; TIGR00747; FabH; 1.
DR   HOGENOMDNA; AERHH_1.PE1001; -.
KW   3-oxoacyl-(acyl carrier protein) synthase III;
KW   Acyltransferase; Complete proteome; Cytoplasm;
KW   Fatty acid biosynthesis; Lipid synthesis; Multifunctional enzyme;
KW   Transferase.
SQ   SEQUENCE   362 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKYANITGWG KCLPPSVLTN DDLSTIMDTS DEWIYPRTGI KARRISHVST SDLATLAGRR
     ALACAGLEAS DLDGIILATA TPDNLLPSAA SAVQKKLGAV NAAVFDLNAA CTGFVYSLSV
     ATSLVQTGMM KKVLVIGAER LTYLLDWARR DTAVLFGDGA GAVVIEASEQ ECGLIANKLG
     CDSEAREILH VPNFGTDRVR FADIDGLFTF NFEGQEIFKR AVRGMGEATN TVLAQAGIAP
     EQIDLIVPHQ ANIRIIETLA KRMNAPMEKV MVNIEHYGNT SAATVPIALC EALEQGRVQP
     NSYLLTAAFG AGLTWGAAII KWGDRVTPIK ACDAELPPCD KSALELIAHA VEGCQKAHAD
     EA
//

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