(data stored in SCRATCH3701 zone)

HOGENOM6: AERHH_1_PE2271

ID   AERHH_1_PE2271                       STANDARD;      PRT;   915 AA.
AC   AERHH_1_PE2271; A0KKQ2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (AERHH_1.PE2271).
GN   Name=gyrA; OrderedLocusNames=AHA_2330;
OS   AEROMONAS HYDROPHILA SUBSP. HYDROPHILA ATCC 7966.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AERHH_1.PE2271.
CC       Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:A0KKQ2_AERHH
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A0KKQ2; -.
DR   EMBL; CP000462; ABK36039.1; -; Genomic_DNA.
DR   RefSeq; YP_856853.1; NC_008570.1.
DR   ProteinModelPortal; A0KKQ2; -.
DR   SMR; A0KKQ2; 30-522, 535-879.
DR   STRING; A0KKQ2; -.
DR   GeneID; 4489759; -.
DR   GenomeReviews; CP000462_GR; AHA_2330.
DR   KEGG; aha:AHA_2330; -.
DR   TIGR; AHA_2330; -.
DR   eggNOG; COG0188; -.
DR   OMA; TGRGRIY; -.
DR   PhylomeDB; A0KKQ2; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; AERHH_1.PE2271; -.
DR   PRODOM; AERHH_1_PE2271.
DR   SWISS-2DPAGE; AERHH_1_PE2271.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   915 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMNELGNDWN
     KPYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQDFSMRY MLVDGQGNFG SVDGDSAAAM
     RYTEVRMARI SHELLADLDK ETVDWVPNYD GTEMIPAVMP TKVPNLLVNG SSGIAVGMAT
     NIPPHNLTEI VNGCLALIEN GDLTIDELMT YITGPDFPTG GIINGRSGIV QAYRTGRGSV
     YVRAKAEVEV DEKTSRETII VHEIPYQVNK ARLIEKIAEL VKEKKIEGIS ALRDESDKDG
     MRIVIEIKRG ESGEIVLNNL YKHTQMQTTF GINMVALDNN QPKVMNLKEI LDAFLLHRRE
     VVTRRTVFEL RKARDRAHIL EGLAVALANI DPVIELIRHS ATPADAKAGL VARGWELGNV
     ASMLEKAGDD AARPEWLEPE FGIREGHYYL TEQQAQAILD LRLHKLTGLE HEKILEEYQS
     LLDLIAELLF ILASPVRLME VIRDELLAVR EQYGDERRTE ISMSSAEINI EDLITPEDVV
     VTLSHQGYVK YQPLSDYEAQ RRGGRGKSAT RIKEEDFVER LLVANTHDTI LCFSTRGKVY
     WLKVYQLPEA SRGARGRPII NLLPLDEGER ITAILPVKEY DADKYVFFAT ANGTVKKTSL
     SDFSRPLSSG IRAINLKEGD ELIGVDITDG SNEIMLFSDA GKVVRFAEGS GRADADATDE
     VDTDDDAGND DDGSDNGEGT ESKGTFKGVR PMGRTAAGVR GIKLGAGDKV VSLIVPRGDG
     AILTATENGY GKRTALDEYP TKSRGTQGVI SIKVDERNGK VIDAIQVEDT DQIMLITNGG
     TLVRTRVSEV SVIGRNTGGV RLIRTGEDET VVGLQRVAES DEDENEVLAV EGEVSEGTDT
     AADTGAVDAG EAGDE
//

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