(data stored in ACNUC7421 zone)

HOGENOM: AERS4_4_PE3956

ID   AERS4_4_PE3956                       STANDARD;      PRT;   715 AA.
AC   AERS4_4_PE3956; A4STF2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Fatty acid oxidation complex subunit alpha;Includes:
DE   RecName: Full=Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA
DE   isomerase/3-hydroxybutyryl-CoA epimerase; EC=4.2.1.17; EC=5.1.2.3;
DE   EC=5.3.3.8;Includes: RecName: Full=3-hydroxyacyl-CoA dehydrogenase;
DE   EC=1.1.1 35; (AERS4_4.PE3956).
GN   Name=fadB; OrderedLocusNames=ASA_4250;
OS   AEROMONAS SALMONICIDA SUBSP. SALMONICIDA A449.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=382245;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AERS4_4.PE3956.
CC       Aeromonas salmonicida subsp. salmonicida A449, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:FADB_AERS4
CC   -!- FUNCTION: Catalyzes the formation of an hydroxyacyl-CoA by
CC       addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA
CC       epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
CC       + NADH.
CC   -!- CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-
CC       CoA + H(2)O.
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxybutanoyl-CoA = (R)-3-
CC       hydroxybutanoyl-CoA.
CC   -!- CATALYTIC ACTIVITY: (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-
CC       CoA.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains (fadB) and two beta
CC       chains (fadA) (By similarity).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the 3-
CC       hydroxyacyl-CoA dehydrogenase family.
CC   -!- GENE_FAMILY: HOG000261344 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A4STF2; -.
DR   EMBL; CP000644; ABO92174.1; -; Genomic_DNA.
DR   RefSeq; YP_001143922.1; NC_009348.1.
DR   ProteinModelPortal; A4STF2; -.
DR   SMR; A4STF2; 1-715.
DR   STRING; A4STF2; -.
DR   GeneID; 4998357; -.
DR   GenomeReviews; CP000644_GR; ASA_4250.
DR   KEGG; asa:ASA_4250; -.
DR   eggNOG; COG1250; -.
DR   OMA; FGEQKAF; -.
DR   PhylomeDB; A4STF2; -.
DR   ProtClustDB; PRK11730; -.
DR   BioCyc; ASAL382245:ASA_4250-MON; -.
DR   GO; GO:0016507; C:fatty acid beta-oxidation multienzyme complex; IEA:InterPro.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
DR   GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:EC.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IEA:EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:EC.
DR   GO; GO:0009062; P:fatty acid catabolic process; IEA:InterPro.
DR   HAMAP; MF_01621; FadB; 1; -.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR001753; Crotonase_core.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR012799; FadB.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 2.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH; 1.
DR   SUPFAM; SSF48179; 6DGDH_C_like; 2.
DR   TIGRFAMs; TIGR02437; FadB; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; FALSE_NEG.
DR   HOGENOMDNA; AERS4_4.PE3956; -.
KW   Complete proteome; Fatty acid metabolism; Isomerase;
KW   Lipid degradation; Lipid metabolism; Lyase; Multifunctional enzyme;
KW   NAD; Oxidoreductase.
SQ   SEQUENCE   715 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIYQGETLSV SYLENGIAEL RFDAPGSVNK LDRATLLSLS EAIAALQQQA DLKGLILTSG
     KDAFIVGADI TEFLELFDLP QEDLLGWLKK ANDIFSAIED LPVPTLSAIK GHALGGGCET
     ILSTDFRLAD TSAKIGLPET KLGIMPGFGG TVRLPRVIGA DNALEWITTG KDYRADDALK
     VGAIDAVVAP DALHSAAVQM MKDAIAGKLN WQSRRAAKKA PLRLSKLEAM MSFSTAAGMV
     AAVAGKHYPA PMTAVKTVEA AAGMSRDEAL VVEAQGFIKL AKTDVAKALV GIFLNDQHIK
     ALAKKAAKQA AKATRHAAVL GAGIMGGGIA YQSASKGIPA VMKDINEKAL ALGMGEATKL
     LNGQLEKGRI DGIKMGQVLS AITPTLSYDN VKHVDLVVEA VVENPKVKAA VLGEVEGIIG
     DDAVLASNTS TIPISLLAKG LKRPQNFCGM HFFNPVHRMP LVEIIRGEQT SDETINRVVA
     YAAAMGKSPV VVNDCPGFFV NRVLFPYFFG FNKLVADGAD FAAVDKVMEK EFGWPMGPAY
     LLDVVGIDTG HHAGDVMAQG FPARMSKEGR TAIDVMYDAS RFGQKNGKGF YAYEQDKKGK
     PKKVADVAAY ELLAPIAKPK QDFDKEAIIA GMMIPMINEV VLCLEEGIVA TPAEADIALV
     YGLGFPPFRG GVFRYLDTIG LDRYVAMADQ YADLGPLYRV SDRLREMAAQ GKTFY
//

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