(data stored in ACNUC14830 zone)

HOGENOM: ANAD2_1_PE100

ID   ANAD2_1_PE100                        STANDARD;      PRT;   1150 AA.
AC   ANAD2_1_PE100; B8J7W9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Methionine synthase; (ANAD2_1.PE100).
GN   OrderedLocusNames=A2cp1_0102;
OS   ANAEROMYXOBACTER DEHALOGENANS 2CP-1.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=455488;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ANAD2_1.PE100.
CC       Anaeromyxobacter dehalogenans 2CP-1, complete genome.
CC       Missing 5 prime End;
CC   -!- ANNOTATIONS ORIGIN:B8J7W9_ANAD2
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- GENE_FAMILY: HOG000251408 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B8J7W9; -.
DR   EMBL; CP001359; ACL63461.1; -; Genomic_DNA.
DR   RefSeq; YP_002490527.1; NC_011891.1.
DR   ProteinModelPortal; B8J7W9; -.
DR   STRING; B8J7W9; -.
DR   GeneID; 7299744; -.
DR   GenomeReviews; CP001359_GR; A2cp1_0102.
DR   KEGG; acp:A2cp1_0102; -.
DR   OMA; ADCIAMS; -.
DR   ProtClustDB; CLSK944813; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008898; F:homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008705; F:methionine synthase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR003759; Met_synth_Cbl-bd.
DR   InterPro; IPR011822; MetH.
DR   InterPro; IPR000489; Pterin-binding.
DR   InterPro; IPR003726; S_MeTrfase.
DR   InterPro; IPR004223; VitB12-dep_Met_synth_activ_dom.
DR   Gene3D; G3DSA:3.40.50.280; B12_bd; 1.
DR   Gene3D; G3DSA:3.20.20.20; Dhdropt_synth; 1.
DR   Gene3D; G3DSA:3.10.196.10; Met_synth_B12; 1.
DR   Gene3D; G3DSA:1.10.1240.10; Met_synth_B12_bd; 1.
DR   Gene3D; G3DSA:3.20.20.330; S_methyl_trans; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF02607; B12-binding_2; 1.
DR   Pfam; PF02965; Met_synt_B12; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   PIRSF; PIRSF000381; MetH; 1.
DR   SUPFAM; SSF52242; Cbl-bd; 1.
DR   SUPFAM; SSF51717; DHP_synth_like; 1.
DR   SUPFAM; SSF56507; Met_synth_B12; 1.
DR   SUPFAM; SSF47644; Met_synth_Cbl-bd; 1.
DR   SUPFAM; SSF82282; S_methyl_trans; 1.
DR   TIGRFAMs; TIGR02082; MetH; 1.
DR   PROSITE; PS50974; ADOMET_ACTIVATION; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS51337; B12_BINDING_NTER; 1.
DR   PROSITE; PS50970; HCY; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
DR   HOGENOMDNA; ANAD2_1.PE100; -.
KW   methionine synthase;
KW   Cobalamin; Cobalt; Complete proteome; Metal-binding;
KW   S-adenosyl-L-methionine; Zinc.
SQ   SEQUENCE   1150 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNFREALERR PLVFDGAMGT QIQRHQLTAA EFGGKEGAND LLTLTRPDLI EEIHARYFAV
     GCDVVETNTF GSSRLKLDEY GLGHRTYEVN CRAAILARRA ADRYSTPDHP RFVAGSIGPT
     GMLPSSSDPA LGNITSDALE RIFFEQAKGL VEGGVDALII ETQQDMLELR AAVLACDAVR
     REALRDVFVI AQPTLIDANG RMLLGTDIGS AVATLERLPV DAVGLNCSTG PDEMRASVKA
     LAEKCSHFVS VLPNAGMPEN VDGRAVYKLS PDDLARALVG FVAEYGVDIV GGCCGTTPEH
     LRKVVEALRA RPAPRRRRPA PAAELSSAMK AVPLAMEPRP LVVGERLNSQ GSRKVKELLL
     ADDYAGLVQI ARGQVEAGAH VLDVCVALNE RDDEAAQMRT LAKLLAQSVD APLMIDSTEP
     DVIEGALKVY PGRCIVNSVN LEKSGERVRR VLPLVRRYGA AVVAMTIDEK GMAQTAERKA
     EVARRIVAVA KDHGIPPDSL VFDALTFTLA TGGEEYRRSA VETLEGIRRI KAENPGVLTT
     LGVSNVSFGL AKSAREVVNS VFLYHAVQAG LDLAIVNPKD ILPYPAIDAA ERALAEDLVF
     DRRPDALARL IAHFGAKGAP EKAAVDPLAG AGGKSAEERI HLQILHRRPE GIEALIDEAL
     TRRSAVDVLN QVLLPAMKDV GDRFGAGELI LPFVLQSAEV MKKAVAHLEQ FLEKKAGATK
     GNVVLATVYG DVHDIGKNLV KTILSNNGFT VHDLGKQVPV ATVLDKALQV NADAIGLSAL
     LVSTSKQMPF CVEELHRRNL SFPVIIGGAA INRRFGYRTH FAQDGTPYAG GVFYAKDAFE
     GLEVVEALVD PARREALRRE VLQKAVAEKS RPAAEPVAQA PARRTGSVAP AARVPAPPFW
     GPRVVPSGSI ALADVWPHLD LAELFKLQWG VKAKGAEYER LIREEFGPKL EELKAEAQAQ
     GWLVPKVVYG YFPCHAEGND LVVLDPAHRK AEVARLQFPR QPDDRNLCLA DYFREERGAD
     VCALQVVTVG DQATHLAEQA QERGDYTRAL FLHGLAVETA EALAEYWHRQ VRGELGLADG
     QGKRYSPGYP SWPELSDQRQ VWKLLDPVRT IGVSLTDACQ MVPEQSTSAI VLHHPDAIYF
     LVRGLERAAG
//

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