(data stored in ACNUC14830 zone)

HOGENOM: ANAD2_1_PE1003

ID   ANAD2_1_PE1003                       STANDARD;      PRT;   308 AA.
AC   ANAD2_1_PE1003; B8JF07;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine
DE   deacetylase; EC=3.5.1 -;AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase;
DE   (ANAD2_1.PE1003).
GN   Name=lpxC; OrderedLocusNames=A2cp1_1013;
OS   ANAEROMYXOBACTER DEHALOGENANS 2CP-1.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Anaeromyxobacter.
OX   NCBI_TaxID=455488;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ANAD2_1.PE1003.
CC       Anaeromyxobacter dehalogenans 2CP-1, complete genome.
CC       Missing 5 prime End;
CC   -!- ANNOTATIONS ORIGIN:B8JF07_ANAD2
CC   -!- FUNCTION: Involved in the biosynthesis of lipid A, a
CC       phosphorylated glycolipid that anchors the lipopolysaccharide to
CC       the outer membrane of the cell (By similarity).
CC   -!- CATALYTIC ACTIVITY: UDP-3-O-(3-hydroxytetradecanoyl)-N-
CC       acetylglucosamine + H(2)O = UDP-3-O-(3-hydroxytetradecanoyl)-
CC       glucosamine + acetate.
CC   -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid
CC       IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and
CC       UDP-N-acetyl-alpha-D-glucosamine: step 2/6.
CC   -!- SIMILARITY: Belongs to the lpxC family.
CC   -!- GENE_FAMILY: HOG000256664 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B8JF07; -.
DR   EMBL; CP001359; ACL64364.1; -; Genomic_DNA.
DR   RefSeq; YP_002491430.1; NC_011891.1.
DR   ProteinModelPortal; B8JF07; -.
DR   STRING; B8JF07; -.
DR   GeneID; 7297059; -.
DR   GenomeReviews; CP001359_GR; A2cp1_1013.
DR   KEGG; acp:A2cp1_1013; -.
DR   OMA; KAYKSGH; -.
DR   ProtClustDB; PRK13186; -.
DR   GO; GO:0008759; F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; IEA:HAMAP.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00388; LpxC; 1; -.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR004463; UDP-acyl_GlcNac_deAcase.
DR   InterPro; IPR011334; UDP-acyl_GlcNac_deAcase_C.
DR   InterPro; IPR015870; UDP-acyl_N-AcGlcN_deAcase_N.
DR   Gene3D; G3DSA:3.30.1700.10; UDP-acyl_N-AcGlcN_deAcase_C; 1.
DR   Gene3D; G3DSA:3.30.230.20; UDP-acyl_N-AcGlcN_deAcase_N; 1.
DR   Pfam; PF03331; LpxC; 1.
DR   SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 2.
DR   TIGRFAMs; TIGR00325; LpxC; 1.
DR   HOGENOMDNA; ANAD2_1.PE1003; -.
KW   Complete proteome; Hydrolase; Lipid A biosynthesis; Lipid synthesis.
SQ   SEQUENCE   308 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASWNQRTVA KRVSCTGVGL HSGRPATLTL APAPADAGIT FVRMDLGVEI PARNEHVVDT
     MLSTSLGRGS ARVATVEHVM AALHGMGIDN CRVEVDGPEI PILDGSAAPF TCLVQEAGVK
     VQPAGKRYLV VDQAVEIRDG DKLARLEPAE GFSVSFTADF GHPLITDQSF QVKLGERAFE
     REVARARTFC FRRDIEKMQA MGLARGGSLE NAIVVDEFSI LNPEGLRFPD EFARHKVLDA
     IGDLALFGLP VVGALVAVKS GHAMNQALVK KVLADPASHR VVRVTGEADA PALRAKVPAL
     AIHEGSAA
//

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