(data stored in ACNUC7421 zone)

HOGENOM: ANAMM_1_PE102

ID   ANAMM_1_PE102                        STANDARD;      PRT;   673 AA.
AC   ANAMM_1_PE102; Q5PBN8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA ligase; EC=6.5.1 2;AltName:
DE   Full=Polydeoxyribonucleotide synthase (ANAMM_1.PE102) [NAD+]; .
GN   Name=ligA; OrderedLocusNames=AM152;
OS   ANAPLASMA MARGINALE STR. ST. MARIES.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Anaplasma.
OX   NCBI_TaxID=234826;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ANAMM_1.PE102.
CC       Anaplasma marginale str. St. Maries, complete genome.
CC       Missing 5 prime End;
CC   -!- ANNOTATIONS ORIGIN:DNLJ_ANAMM
CC   -!- FUNCTION: DNA ligase that catalyzes the formation of
CC       phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl
CC       groups in double-stranded DNA using NAD as a coenzyme and as the
CC       energy source for the reaction. It is essential for DNA
CC       replication and repair of damaged DNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigA
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 BRCT domain.
CC   -!- GENE_FAMILY: HOG000218459 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5PBN8; -.
DR   EMBL; CP000030; AAV86291.1; -; Genomic_DNA.
DR   RefSeq; YP_153546.1; NC_004842.2.
DR   HSSP; O87703; 1B04.
DR   ProteinModelPortal; Q5PBN8; -.
DR   STRING; Q5PBN8; -.
DR   GeneID; 3171105; -.
DR   GenomeReviews; CP000030_GR; AM152.
DR   KEGG; ama:AM152; -.
DR   eggNOG; COG0272; -.
DR   OMA; TQKVGAT; -.
DR   ProtClustDB; CLSK747278; -.
DR   BioCyc; AMAR234826:AM152-MON; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0003911; F:DNA ligase (NAD+) activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01588; DNA_ligase_A; 1; -.
DR   InterPro; IPR001357; BRCT.
DR   InterPro; IPR018239; DNA_ligase_AS.
DR   InterPro; IPR004150; DNA_ligase_OB.
DR   InterPro; IPR001679; DNAligase.
DR   InterPro; IPR013839; DNAligase_adenylation.
DR   InterPro; IPR013840; DNAligase_N.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004149; Znf_DNAligase_C4.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF01653; DNA_ligase_aden; 1.
DR   Pfam; PF03120; DNA_ligase_OB; 1.
DR   Pfam; PF03119; DNA_ligase_ZBD; 1.
DR   PIRSF; PIRSF001604; LigA; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SMART; SM00532; LIGANc; 1.
DR   SUPFAM; SSF52113; BRCT; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   SUPFAM; SSF47781; RuvA_2_like; 1.
DR   TIGRFAMs; TIGR00575; Dnlj; 1.
DR   PROSITE; PS50172; BRCT; 1.
DR   PROSITE; PS01055; DNA_LIGASE_N1; 1.
DR   PROSITE; PS01056; DNA_LIGASE_N2; FALSE_NEG.
DR   HOGENOMDNA; ANAMM_1.PE102; -.
KW   Complete proteome; DNA damage; DNA repair; DNA replication; Ligase;
KW   Magnesium; Manganese; Metal-binding; NAD; Zinc.
SQ   SEQUENCE   673 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLEQARRRLA GLNAKLRHHD VLYHGLDAPE VTDHQYDLLV QEKKRLLDEF PDISQYDDYA
     DVVGTPKIDS RFPKVQHLEP MLSLENAFTV QDVEKFITRV RRFLELQPDD ILELSCELKM
     DGMSFSALYH GGKLTRVATR GNGHFGEDIT TNAMVLRGLP HQLDSAPEVL EVRGEIYMHH
     EDFEKLRGSC NFANPRNAAA GSIRQLNQKI VEERNLSYVA YSAVNSTFAT QQEILKQLDE
     WGFHTNKQVL FTDKIEEAIA FYNSVYTTRS ALGYDIDGVV YKVNSTNFQK LLGATGKSPR
     WAIAHKFPST EARTKLLDIT VQVGRTGVVT PIAELEPINI GGVMVSRASL HNLNEIERKD
     VRIGDLVIVK RAGEVIPQVV DVDKTLRSSG TQKFVFPSHC PSCGSKLHRE PGEVALRCVA
     ELSCKAQALE RVKHFVSRDG LNIMGLGAKQ IEFFCNHGLI GSIADIFSLE EKLHGINLDT
     EHGWGEKSVA NLIAAIRNSA TVRLSNFIFA LGIRFIGVGA AKLVAEHYRS YKNWHQAMLA
     LTETHDTVQI RGLGEKSISS LKAFFSVQGN LEVLESLSAK LNILDEASPA QRGSSAISGK
     TVVFTGTLES MSRTEAKLQA ESLGAKVANS VSANTWLLVA GSNPGSKHEK ALSLNVRVID
     EQTWVKMVED ARS
//

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